ACHA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACHA5_HUMAN
• UniProt AC: P30532
• Protein Name: Neuronal acetylcholine receptor subunit alpha-5
• Gene Name: CHRNA5
• Organism: Homo sapiens (Human).
• Sequence Length: 468
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane..
• Protein Sequence: MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Ubiquitination	SEPSSIAKHEDSLLK CCCCHHHHCCHHHHH	45.95	-
49	Phosphorylation	SIAKHEDSLLKDLFQ HHHHCCHHHHHHHHH	32.39	24719451
52	Ubiquitination	KHEDSLLKDLFQDYE HCCHHHHHHHHHHHH	58.65	21906983
71	Ubiquitination	PVEHLNDKIKIKFGL CHHHHCHHHHHCHHE	44.84	-
94	Phosphorylation	DEKNQLMTTNVWLKQ CHHCCEEEEEEEEEE	24.66	30266825
95	Phosphorylation	EKNQLMTTNVWLKQE HHCCEEEEEEEEEEC	17.51	30266825
100	Ubiquitination	MTTNVWLKQEWIDVK EEEEEEEEECEEEEE	30.38	-
107	Ubiquitination	KQEWIDVKLRWNPDD EECEEEEEECCCCCC	28.69	21906983
119	Ubiquitination	PDDYGGIKVIRVPSD CCCCCCEEEEEECCC	34.58	21890473
147	Phosphorylation	DGRFEGTSTKTVIRY CCCEECCCCCEEEEE	38.47	-
148	Phosphorylation	GRFEGTSTKTVIRYN CCEECCCCCEEEEEC	30.49	-
149	Ubiquitination	RFEGTSTKTVIRYNG CEECCCCCEEEEECC	40.33	21906983
150	Phosphorylation	FEGTSTKTVIRYNGT EECCCCCEEEEECCE	22.66	-
155	N-linked_Glycosylation	TKTVIRYNGTVTWTP CCEEEEECCEEEECC	29.79	UniProtKB CARBOHYD
183	N-linked_Glycosylation	FFPFDLQNCSMKFGS EECCCCCCCEEEECE	27.42	UniProtKB CARBOHYD
209	Ubiquitination	LEDQDVDKRDFFDNG ECCCCCCHHHCCCCC	54.43	-
227	Ubiquitination	IVSATGSKGNRTDSC EEEEECCCCCCCCCC	62.64	21890473
229	N-linked_Glycosylation	SATGSKGNRTDSCCW EEECCCCCCCCCCCC	47.63	UniProtKB CARBOHYD
354	Ubiquitination	AMAPLVRKIFLHTLP CHHHHHHHHHHHHHH	30.26	-
373	Phosphorylation	MRSHVDRYFTQKEET HHHHHHHHCCCHHHC	13.40	-
377	Ubiquitination	VDRYFTQKEETESGS HHHHCCCHHHCCCCC	55.23	21906983
387	Ubiquitination	TESGSGPKSSRNTLE CCCCCCCCCHHHHHH	65.67	21906983
409	Ubiquitination	YITRHIMKENDVREV HHHHHHHHHCCHHHH	53.41	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACHA5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACHA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACHA5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ACHA5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00611: Mecamylamine hydrochloride (USP); Inversine (TN)
• D00999: Acetylcholine chloride (JP16/USP/INN); Miochol (TN)
• D02202: Lobeline hydrochloride (JAN)
• D02204: Hexamethonium bromide (JAN/INN); Hexamethonium bromide (TN)
• D02364: Lobeline (INN)
• D08138: Lobeline sulfate; Smokeless (TN)
• DrugBank
• There are no disease associations of PTM sites.