dbPTM

PIGM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIGM_HUMAN
UniProt AC	Q9H3S5
Protein Name	GPI mannosyltransferase 1
Gene Name	PIGM
Organism	Homo sapiens (Human).
Sequence Length	423
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly..
Protein Sequence	MGSTKHWGEWLLNLKVAPAGVFGVAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCDLLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLMLWFIGQAMWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEEPLTERIKYD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
159	Phosphorylation	SLVLMVLYLIKKRLV HHHHHHHHHHHHHHH	8.58	19664994
209	Phosphorylation	KSLRQFRYTFQACLY CCHHHHHHHHHHHHH	17.13	-
272	Phosphorylation	RDIRHNFSPYFYMLY HHHHHCCCCEEEEEH	24.81	-
274	Phosphorylation	IRHNFSPYFYMLYLT HHHCCCCEEEEEHHC	13.22	-
276	Phosphorylation	HNFSPYFYMLYLTAE HCCCCEEEEEHHCCC	4.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIGM_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PIGM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIGM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
STAR7_HUMAN	STARD7	physical	26186194
STAR7_HUMAN	STARD7	physical	28514442

Drug and Disease Associations

Kegg Disease
H01127	Glycosylphosphatidylinositol (GPI) deficiency
OMIM Disease
610293	Glycosylphosphatidylinositol deficiency (GPID)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIGM_HUMAN

Related Literatures of Post-Translational Modification