SC6A6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC6A6_HUMAN
• UniProt AC: P31641
• Protein Name: Sodium- and chloride-dependent taurine transporter
• Gene Name: SLC6A6
• Organism: Homo sapiens (Human).
• Sequence Length: 620
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake..
• Protein Sequence: MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MATKEKLQCLK ----CCHHHHHHHHH	43.23	-
6	Ubiquitination	--MATKEKLQCLKDF --CCHHHHHHHHHHH	45.47	-
11	Ubiquitination	KEKLQCLKDFHKDIL HHHHHHHHHHHHHHH	67.01	-
11	Sumoylation	KEKLQCLKDFHKDIL HHHHHHHHHHHHHHH	67.01	-
15	Ubiquitination	QCLKDFHKDILKPSP HHHHHHHHHHHCCCC	46.59	21890473
19	Ubiquitination	DFHKDILKPSPGKSP HHHHHHHCCCCCCCC	43.73	21890473
19	Sumoylation	DFHKDILKPSPGKSP HHHHHHHCCCCCCCC	43.73	-
21	Phosphorylation	HKDILKPSPGKSPGT HHHHHCCCCCCCCCC	44.70	25159151
24	Ubiquitination	ILKPSPGKSPGTRPE HHCCCCCCCCCCCCH	57.78	21890473
25	Phosphorylation	LKPSPGKSPGTRPED HCCCCCCCCCCCCHH	34.18	29255136
28	Phosphorylation	SPGKSPGTRPEDEAE CCCCCCCCCCHHHCC	46.57	23663014
37	Ubiquitination	PEDEAEGKPPQREKW CHHHCCCCCCCHHHH	45.06	21890473
163	N-linked_Glycosylation	ELPWAHCNHSWNTPH HCCCCCCCCCCCCCC	23.51	UniProtKB CARBOHYD
179	N-linked_Glycosylation	MEDTMRKNKSVWITI HHHHHHHCCCEEEEE	31.31	UniProtKB CARBOHYD
190	N-linked_Glycosylation	WITISSTNFTSPVIE EEEEECCCCCCCCHH	39.90	19349973
275	Ubiquitination	PGAGAGIKFYLYPDI CCCCCCCEEEECCCC	27.34	-
322	Phosphorylation	YNKYKYNSYRDCMLL CCCCCCCCHHHHCHH	20.60	-
577	Ubiquitination	GPFLVRVKYLLTPRE CCEEEEEEEEECCCC	21.44	21890473
577	Ubiquitination	GPFLVRVKYLLTPRE CCEEEEEEEEECCCC	21.44	21890473
596	Phosphorylation	AVEREGATPYNSRTV EEECCCCCCCCCCEE	36.84	28555341
610	Ubiquitination	VMNGALVKPTHIIVE EECCCCCCCEEEEEE	45.08	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC6A6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
322	S	Phosphorylation	Down-regulated upon Ser-322 phosphorylation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC6A6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SC6A6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190, AND MASSSPECTROMETRY.
PubMed: 19349973