ISLR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ISLR_HUMAN
• UniProt AC: O14498
• Protein Name: Immunoglobulin superfamily containing leucine-rich repeat protein
• Gene Name: ISLR
• Organism: Homo sapiens (Human).
• Sequence Length: 428
• Subcellular Localization: Secreted .
• Protein Sequence: MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFHGKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLLLFFFLTSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	VPPGFPANVTTLSLS CCCCCCCCEEEEECC	31.72	UniProtKB CARBOHYD
309	N-linked_Glycosylation	PRFQAFANGSLLIPD CCCHHHCCCCEEECC	33.85	UniProtKB CARBOHYD
371	O-linked_Glycosylation	VEGKGCYTVDNEVQP CCCCCEEEECCCCCC	26.01	OGP
379	O-linked_Glycosylation	VDNEVQPSGPEDNVV ECCCCCCCCCCCCEE	50.30	OGP
389	Phosphorylation	EDNVVIIYLSRAGNP CCCEEEEEEECCCCH	6.36	29759185
391	Phosphorylation	NVVIIYLSRAGNPEA CEEEEEEECCCCHHH	11.78	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ISLR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ISLR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ISLR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
TBB4A_HUMAN	TUBB4A	physical	26186194
TBB3_HUMAN	TUBB3	physical	26186194
TBB8_HUMAN	TUBB8	physical	26186194
ADT1_HUMAN	SLC25A4	physical	26186194
ADT3_HUMAN	SLC25A6	physical	26186194
GRP78_HUMAN	HSPA5	physical	26186194
MDN1_HUMAN	MDN1	physical	26186194
CA2D1_HUMAN	CACNA2D1	physical	26186194
PGAP1_HUMAN	PGAP1	physical	26186194
SGPL1_HUMAN	SGPL1	physical	26186194
LPCT4_HUMAN	LPCAT4	physical	26186194
CDC6_HUMAN	CDC6	physical	26186194
GALNS_HUMAN	GALNS	physical	26186194
SETX_HUMAN	SETX	physical	26186194
GPD1L_HUMAN	GPD1L	physical	26186194
ARSK_HUMAN	ARSK	physical	26186194
CNPY3_HUMAN	CNPY3	physical	26186194
UBP3_HUMAN	USP3	physical	26186194
ELYS_HUMAN	AHCTF1	physical	26186194
ACOT9_HUMAN	ACOT9	physical	26186194
RHBT3_HUMAN	RHOBTB3	physical	26186194
TX264_HUMAN	TEX264	physical	26186194
CD109_HUMAN	CD109	physical	26186194
PCYOX_HUMAN	PCYOX1	physical	26186194
VAPA_HUMAN	VAPA	physical	26186194
CATF_HUMAN	CTSF	physical	26186194
S2540_HUMAN	SLC25A40	physical	26186194
MCAT_HUMAN	SLC25A20	physical	26186194
RTEL1_HUMAN	RTEL1	physical	26186194
NEK4_HUMAN	NEK4	physical	26186194
INT4_HUMAN	INTS4	physical	26186194
MTG1_HUMAN	MTG1	physical	26186194
MGT5A_HUMAN	MGAT5	physical	26186194
GCNT1_HUMAN	GCNT1	physical	26186194
CHSS3_HUMAN	CHSY3	physical	26186194
S11IP_HUMAN	STK11IP	physical	26186194
ZRAB3_HUMAN	ZRANB3	physical	26186194
AT133_HUMAN	ATP13A3	physical	26186194
LRC40_HUMAN	LRRC40	physical	26186194
TM39B_HUMAN	TMEM39B	physical	26186194
BCKD_HUMAN	BCKDK	physical	26186194
SPG7_HUMAN	SPG7	physical	26186194
PPOX_HUMAN	PPOX	physical	26186194
GNPTG_HUMAN	GNPTG	physical	26186194
BMP7_HUMAN	BMP7	physical	26186194
TP4A1_HUMAN	PTP4A1	physical	26186194
NTCP7_HUMAN	SLC10A7	physical	26186194
XRCC3_HUMAN	XRCC3	physical	26186194
LRFN3_HUMAN	LRFN3	physical	26186194
ZRAB3_HUMAN	ZRANB3	physical	28514442
CDC6_HUMAN	CDC6	physical	28514442
CNPY3_HUMAN	CNPY3	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442
RTEL1_HUMAN	RTEL1	physical	28514442
CNPY4_HUMAN	CNPY4	physical	28514442
MTG1_HUMAN	MTG1	physical	28514442
UBP3_HUMAN	USP3	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
MCAT_HUMAN	SLC25A20	physical	28514442
GPD1L_HUMAN	GPD1L	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
RHBT3_HUMAN	RHOBTB3	physical	28514442
NEK4_HUMAN	NEK4	physical	28514442
NTCP7_HUMAN	SLC10A7	physical	28514442
CHSS3_HUMAN	CHSY3	physical	28514442
ADT3_HUMAN	SLC25A6	physical	28514442
GALNS_HUMAN	GALNS	physical	28514442
GCNT1_HUMAN	GCNT1	physical	28514442
SPG7_HUMAN	SPG7	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
AT133_HUMAN	ATP13A3	physical	28514442
LMLN_HUMAN	LMLN	physical	28514442
ADT1_HUMAN	SLC25A4	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
XRCC3_HUMAN	XRCC3	physical	28514442
SETX_HUMAN	SETX	physical	28514442
SGPL1_HUMAN	SGPL1	physical	28514442
TBB4A_HUMAN	TUBB4A	physical	28514442
BCKD_HUMAN	BCKDK	physical	28514442
TM39B_HUMAN	TMEM39B	physical	28514442
GPC3_HUMAN	GPC3	physical	28514442
LRC40_HUMAN	LRRC40	physical	28514442
GT253_HUMAN	CERCAM	physical	28514442
CA2D1_HUMAN	CACNA2D1	physical	28514442
PGAP1_HUMAN	PGAP1	physical	28514442
TX264_HUMAN	TEX264	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.