UniProt ID | GCNT1_HUMAN | |
---|---|---|
UniProt AC | Q02742 | |
Protein Name | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase | |
Gene Name | GCNT1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 428 | |
Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein . Also detected in the trans-Golgi network. |
|
Protein Description | Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.. | |
Protein Sequence | MLRTLLRRRLFSYPTKYYFMVLVLSLITFSVLRIHQKPEFVSVRHLELAGENPSSDINCTKVLQGDVNEIQKVKLEILTVKFKKRPRWTPDDYINMTSDCSSFIKRRKYIVEPLSKEEAEFPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVDTKSEDSYLAAVMGIASCFSNVFVASRLESVVYASWSRVQADLNCMKDLYAMSANWKYLINLCGMDFPIKTNLEIVRKLKLLMGENNLETERMPSHKEERWKKRYEVVNGKLTNTGTVKMLPPLETPLFSGSAYFVVSREYVGYVLQNEKIQKLMEWAQDTYSPDEYLWATIQRIPEVPGSLPASHKYDLSDMQAVARFVKWQYFEGDVSKGAPYPPCDGVHVRSVCIFGAGDLNWMLRKHHLFANKFDVDVDLFAIQCLDEHLRHKALETLKH | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
15 | Phosphorylation | RRLFSYPTKYYFMVL HHHHCCCHHHHHHHH | 24.36 | 22210691 | |
17 | Phosphorylation | LFSYPTKYYFMVLVL HHCCCHHHHHHHHHH | 12.38 | 27762562 | |
18 | Phosphorylation | FSYPTKYYFMVLVLS HCCCHHHHHHHHHHH | 6.17 | 27762562 | |
52 | N-linked_Glycosylation | HLELAGENPSSDINC EEEECCCCCCCCCCC | 40.61 | UniProtKB CARBOHYD | |
58 | N-linked_Glycosylation | ENPSSDINCTKVLQG CCCCCCCCCCEEEEC | 32.18 | UniProtKB CARBOHYD | |
95 | N-linked_Glycosylation | WTPDDYINMTSDCSS CCCCCCCCCCCCHHH | 22.81 | UniProtKB CARBOHYD | |
102 | Phosphorylation | NMTSDCSSFIKRRKY CCCCCHHHHHHHCCE | 37.00 | 24719451 | |
204 | Phosphorylation | LNCMKDLYAMSANWK HHHHHHHHHHHCCHH | 15.47 | - | |
207 | Phosphorylation | MKDLYAMSANWKYLI HHHHHHHHCCHHHHH | 15.41 | - | |
225 | Phosphorylation | GMDFPIKTNLEIVRK CCCCCCCCCHHHHHH | 45.84 | 29083192 | |
257 | Acetylation | HKEERWKKRYEVVNG CHHHHHHHHEEEECC | 53.93 | 19413330 | |
259 | Phosphorylation | EERWKKRYEVVNGKL HHHHHHHEEEECCEE | 23.19 | 28270605 | |
267 | Phosphorylation | EVVNGKLTNTGTVKM EEECCEEECCCCCCC | 33.93 | 28270605 | |
269 | Phosphorylation | VNGKLTNTGTVKMLP ECCEEECCCCCCCCC | 29.06 | 28270605 | |
271 | Phosphorylation | GKLTNTGTVKMLPPL CEEECCCCCCCCCCC | 18.21 | 28270605 | |
288 | Phosphorylation | PLFSGSAYFVVSREY CCCCCCEEEEEEHHH | 9.90 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GCNT1_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GCNT1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GCNT1_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
RL40_HUMAN | UBA52 | physical | 28514442 | |
TTC19_HUMAN | TTC19 | physical | 28514442 | |
S2546_HUMAN | SLC25A46 | physical | 28514442 | |
LRP1_HUMAN | LRP1 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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