GCNT1_HUMAN - dbPTM
GCNT1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GCNT1_HUMAN
UniProt AC Q02742
Protein Name Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Gene Name GCNT1
Organism Homo sapiens (Human).
Sequence Length 428
Subcellular Localization Golgi apparatus membrane
Single-pass type II membrane protein . Also detected in the trans-Golgi network.
Protein Description Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes..
Protein Sequence MLRTLLRRRLFSYPTKYYFMVLVLSLITFSVLRIHQKPEFVSVRHLELAGENPSSDINCTKVLQGDVNEIQKVKLEILTVKFKKRPRWTPDDYINMTSDCSSFIKRRKYIVEPLSKEEAEFPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVDTKSEDSYLAAVMGIASCFSNVFVASRLESVVYASWSRVQADLNCMKDLYAMSANWKYLINLCGMDFPIKTNLEIVRKLKLLMGENNLETERMPSHKEERWKKRYEVVNGKLTNTGTVKMLPPLETPLFSGSAYFVVSREYVGYVLQNEKIQKLMEWAQDTYSPDEYLWATIQRIPEVPGSLPASHKYDLSDMQAVARFVKWQYFEGDVSKGAPYPPCDGVHVRSVCIFGAGDLNWMLRKHHLFANKFDVDVDLFAIQCLDEHLRHKALETLKH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationRRLFSYPTKYYFMVL
HHHHCCCHHHHHHHH
24.3622210691
17PhosphorylationLFSYPTKYYFMVLVL
HHCCCHHHHHHHHHH
12.3827762562
18PhosphorylationFSYPTKYYFMVLVLS
HCCCHHHHHHHHHHH
6.1727762562
52N-linked_GlycosylationHLELAGENPSSDINC
EEEECCCCCCCCCCC
40.61UniProtKB CARBOHYD
58N-linked_GlycosylationENPSSDINCTKVLQG
CCCCCCCCCCEEEEC
32.18UniProtKB CARBOHYD
95N-linked_GlycosylationWTPDDYINMTSDCSS
CCCCCCCCCCCCHHH
22.81UniProtKB CARBOHYD
102PhosphorylationNMTSDCSSFIKRRKY
CCCCCHHHHHHHCCE
37.0024719451
204PhosphorylationLNCMKDLYAMSANWK
HHHHHHHHHHHCCHH
15.47-
207PhosphorylationMKDLYAMSANWKYLI
HHHHHHHHCCHHHHH
15.41-
225PhosphorylationGMDFPIKTNLEIVRK
CCCCCCCCCHHHHHH
45.8429083192
257AcetylationHKEERWKKRYEVVNG
CHHHHHHHHEEEECC
53.9319413330
259PhosphorylationEERWKKRYEVVNGKL
HHHHHHHEEEECCEE
23.1928270605
267PhosphorylationEVVNGKLTNTGTVKM
EEECCEEECCCCCCC
33.9328270605
269PhosphorylationVNGKLTNTGTVKMLP
ECCEEECCCCCCCCC
29.0628270605
271PhosphorylationGKLTNTGTVKMLPPL
CEEECCCCCCCCCCC
18.2128270605
288PhosphorylationPLFSGSAYFVVSREY
CCCCCCEEEEEEHHH
9.90-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GCNT1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GCNT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GCNT1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RL40_HUMANUBA52physical
28514442
TTC19_HUMANTTC19physical
28514442
S2546_HUMANSLC25A46physical
28514442
LRP1_HUMANLRP1physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GCNT1_HUMAN

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Related Literatures of Post-Translational Modification

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