PGAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGAP1_HUMAN
• UniProt AC: Q75T13
• Protein Name: GPI inositol-deacylase
• Gene Name: PGAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 922
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity)..
• Protein Sequence: MFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYLYGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLYKGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQVRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPAIISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKYLTLRLQDYPSLSHLVVYVPSVRGSKFVVDCEFFKKEKRYIQLPVTHLFSFGLSSRKVVLNTNGLYYNLELLNFGQIYQAFKINVVSKCSAVKEEITSIYRLHIPWSYEDSLTIAQAPSSTEISLKLHIAQPENNTHVALFKMYTSSDCRYEVTVKTSFSQILGQVVRFHGGALPAYVVSNILLAYRGQLYSLFSTGCCLEYATMLDKEAKPYKVDPFVIIIKFLLGYKWFKELWDVLLLPELDAVILTCQSMCFPLISLILFLFGTCTAYWSGLLSSASVRLLSSLWLALKRPSELPKDIKMISPDLPFLTIVLIIVSWTTCGALAILLSYLYYVFKVVHLQASLTTFKNSQPVNPKHSRRSEKKSNHHKDSSIHHLRLSANDAEDSLRMHSTVINLLTWIVLLSMPSLIYWLKNLRYYFKLNPDPCKPLAFILIPTMAILGNTYTVSIKSSKLLKTTSQFPLPLAVGVIAFGSAHLYRLPCFVFIPLLLHALCNFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
144	Phosphorylation	GGSLQKQTKFVHECI CCCHHHHHHHHHHHH	33.22	-
159	Ubiquitination	KTILKLYKGQEFAPK HHHHHHHCCCCCCCC	65.63	32142685
187	Ubiquitination	ARALLTLKNFKHDLI HHHHHHHCCCCHHHH	55.92	-
308	Ubiquitination	DLIDADTKQITQNSK HHHCCCCHHHHHCHH	40.00	-
402	N-linked_Glycosylation	SWIFACINSTSMCLQ CEEEEHHCCCCCCCC	38.84	UniProtKB CARBOHYD
558	N-linked_Glycosylation	LHIAQPENNTHVALF EEEECCCCCCEEEEE	66.44	UniProtKB CARBOHYD
601	Phosphorylation	HGGALPAYVVSNILL CCCCCCHHHHHHHHH	10.23	-
610	Phosphorylation	VSNILLAYRGQLYSL HHHHHHHHHHHHHHH	18.42	-
637	Phosphorylation	LDKEAKPYKVDPFVI HCCCCCCCCCCCHHH	23.96	-
782	Ubiquitination	NSQPVNPKHSRRSEK CCCCCCCCCCCCCCC	49.35	29967540
797	Phosphorylation	KSNHHKDSSIHHLRL CCCCCCCCCCEEEEC	35.68	23312004
798	Phosphorylation	SNHHKDSSIHHLRLS CCCCCCCCCEEEECC	35.75	23312004
805	Phosphorylation	SIHHLRLSANDAEDS CCEEEECCCCCHHHH	20.70	25278378
812	Phosphorylation	SANDAEDSLRMHSTV CCCCHHHHHHHHHHH	14.91	25278378
830	Phosphorylation	LTWIVLLSMPSLIYW HHHHHHHHHHHHHHH	25.20	-
882	Phosphorylation	KSSKLLKTTSQFPLP ECCCCCCCCCCCCCC	31.48	-
883	Phosphorylation	SSKLLKTTSQFPLPL CCCCCCCCCCCCCCC	20.95	-
884	Phosphorylation	SKLLKTTSQFPLPLA CCCCCCCCCCCCCCE	34.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGAP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGAP1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PGAP1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.