| UniProt ID | BMP7_HUMAN | |
|---|---|---|
| UniProt AC | P18075 | |
| Protein Name | Bone morphogenetic protein 7 | |
| Gene Name | BMP7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 431 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.. | |
| Protein Sequence | MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 162 | Ubiquitination | EFRFDLSKIPEGEAV CEEECHHHCCCCCCE | 70.36 | 21906983 | |
| 177 | Phosphorylation | TAAEFRIYKDYIRER EHHEEEEHHHHHHHH | 8.11 | 29496907 | |
| 178 | Ubiquitination | AAEFRIYKDYIRERF HHEEEEHHHHHHHHC | 41.50 | - | |
| 180 | Phosphorylation | EFRIYKDYIRERFDN EEEEHHHHHHHHCCC | 9.57 | 29496907 | |
| 187 | N-linked_Glycosylation | YIRERFDNETFRISV HHHHHCCCCCEEEEH | 47.71 | UniProtKB CARBOHYD | |
| 294 | Phosphorylation | HFRSIRSTGSKQRSQ EHHHHHCCCCHHHHC | 35.31 | 27134283 | |
| 296 | Phosphorylation | RSIRSTGSKQRSQNR HHHHCCCCHHHHCCC | 26.21 | 27134283 | |
| 300 | Phosphorylation | STGSKQRSQNRSKTP CCCCHHHHCCCCCCC | 29.34 | 27134283 | |
| 302 | N-linked_Glycosylation | GSKQRSQNRSKTPKN CCHHHHCCCCCCCCH | 51.98 | UniProtKB CARBOHYD | |
| 306 | Phosphorylation | RSQNRSKTPKNQEAL HHCCCCCCCCHHHHH | 40.52 | - | |
| 321 | N-linked_Glycosylation | RMANVAENSSSDQRQ HHHHHHCCCCHHHHH | 37.14 | UniProtKB CARBOHYD | |
| 322 | Phosphorylation | MANVAENSSSDQRQA HHHHHCCCCHHHHHH | 23.79 | - | |
| 323 | Phosphorylation | ANVAENSSSDQRQAC HHHHCCCCHHHHHHH | 49.90 | - | |
| 372 | N-linked_Glycosylation | FPLNSYMNATNHAIV CCHHHHHCCCCHHHH | 35.07 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BMP7_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BMP7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BMP7_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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