GSTCD_HUMAN - dbPTM
GSTCD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GSTCD_HUMAN
UniProt AC Q8NEC7
Protein Name Glutathione S-transferase C-terminal domain-containing protein
Gene Name GSTCD
Organism Homo sapiens (Human).
Sequence Length 633
Subcellular Localization Cytoplasm .
Protein Description
Protein Sequence MKAIKKSLTEEEYLYLDFSHQTEGCIFPLHTSVTLFLLSYCDCKIFKICLVVTKEVSRDSSLLRDDLIQDVEIQIISRQELPPIVQNCCLPAVVERSDNFCRAGLAVVLRHIIQKSYEADPLKKELLELLGFKKTCLKACAEVSQWTRLCELTIPLAIENFLRESSDQPPTIPVEILQLEKKLSEPVRVHNDDKLRRQKLKQQKADGVGPPLTKGKAKSKVHTQETSEGLDSSSKSLELKVAFSKLTVQEEPATTNREPSHIRKAKASDLPPLEHVFAEGLYFTLADIVLLPCIHHFLVIISRKFSEKLVEFPLLASWYQRIQEVPGVKTAASKCGIQFLHLPKLLTTSTEQHPNLCEVPGVEEQSDPLFIGGPRPTMAKLMEKGIEVMFSPHPCPTWTLDWNVLPAAVSPKEGKMSSDRALRKQQQLNNLVYVVTNQAKPGDRIVDFCSGGGHVGIVLAHMLPSCQVTLIENKELSLIRAKKRSDELGLSNIWFIQANMEYFTGMFNIGVALHACGVATDMVIEHCIKTRASFVTCPCCYGFIQNTSKFNFPKSEQFKKTLSYKEHMILCRFADQTAVQLPPQRRLIGKQCMCLVDLDRARAAEECGYSVQVISMEPESCSPKNNMIVGVPI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
61PhosphorylationKEVSRDSSLLRDDLI
CCCCCCCHHCCCCCC		35.3924719451
97PhosphorylationLPAVVERSDNFCRAG
HHHHHHCCCCCHHHH		24.3317924679
117PhosphorylationRHIIQKSYEADPLKK
HHHHHHHCCCCHHHH		23.36-
133UbiquitinationLLELLGFKKTCLKAC
HHHHHCCHHHHHHHH		45.4321906983
133 (in isoform 1)Ubiquitination-45.4321906983
134UbiquitinationLELLGFKKTCLKACA
HHHHCCHHHHHHHHH		42.06-
135PhosphorylationELLGFKKTCLKACAE
HHHCCHHHHHHHHHH		24.5429514088
181 (in isoform 1)Ubiquitination-68.5521906983
181UbiquitinationVEILQLEKKLSEPVR
HHHHHHHHHHCCCCC		68.5521906983
182UbiquitinationEILQLEKKLSEPVRV
HHHHHHHHHCCCCCC		48.12-
184PhosphorylationLQLEKKLSEPVRVHN
HHHHHHHCCCCCCCC		49.0517924679
223PhosphorylationKAKSKVHTQETSEGL
CCCCCCCCCCCCCCC		30.9623403867
226PhosphorylationSKVHTQETSEGLDSS
CCCCCCCCCCCCCCC		23.4323403867
227PhosphorylationKVHTQETSEGLDSSS
CCCCCCCCCCCCCCC		28.9923403867
232PhosphorylationETSEGLDSSSKSLEL
CCCCCCCCCCCEEEH		41.3730278072
233PhosphorylationTSEGLDSSSKSLELK
CCCCCCCCCCEEEHH		41.2630278072
234PhosphorylationSEGLDSSSKSLELKV
CCCCCCCCCEEEHHH		30.1630278072
235UbiquitinationEGLDSSSKSLELKVA
CCCCCCCCEEEHHHE		62.09-
236PhosphorylationGLDSSSKSLELKVAF
CCCCCCCEEEHHHEE		29.0828450419
245UbiquitinationELKVAFSKLTVQEEP
EHHHEEEECEECCCC		41.55-
260PhosphorylationATTNREPSHIRKAKA
CCCCCCCHHHHHCCH		27.1323532336
264UbiquitinationREPSHIRKAKASDLP
CCCHHHHHCCHHCCC		54.35-
306PhosphorylationVIISRKFSEKLVEFP
HHHHHHCHHHHHCCH		36.5424719451
329UbiquitinationIQEVPGVKTAASKCG
HHHCCCHHHHHHHHC		38.062190698
329 (in isoform 1)Ubiquitination-38.0621906983
330PhosphorylationQEVPGVKTAASKCGI
HHCCCHHHHHHHHCC		25.6725693802
333PhosphorylationPGVKTAASKCGIQFL
CCHHHHHHHHCCEEE		26.4725693802
334UbiquitinationGVKTAASKCGIQFLH
CHHHHHHHHCCEEEC		31.58-
541PhosphorylationFVTCPCCYGFIQNTS
EEECCCHHHHCCCCC		23.07-
548PhosphorylationYGFIQNTSKFNFPKS
HHHCCCCCCCCCCCH		42.68-
554UbiquitinationTSKFNFPKSEQFKKT
CCCCCCCCHHHHHHH		63.59-
590UbiquitinationPQRRLIGKQCMCLVD
CCCCCCCCEEEEEEE		33.07-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GSTCD_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GSTCD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GSTCD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KDM1A_HUMANKDM1Aphysical
23455924
ANM6_HUMANPRMT6physical
23455924
SUV92_HUMANSUV39H2physical
23455924
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GSTCD_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, AND MASSSPECTROMETRY.

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