dbPTM

CLCKA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLCKA_HUMAN
UniProt AC	P51800
Protein Name	Chloride channel protein ClC-Ka
Gene Name	CLCNKA
Organism	Homo sapiens (Human).
Sequence Length	687
Subcellular Localization	Membrane Multi-pass membrane protein.
Protein Description	Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms..
Protein Sequence	MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	GDSHLLRYLSWTVYP CCHHHHHHHHCEEEE	12.69	-
121	Phosphorylation	ITPSSGGSGIPELKT CCCCCCCCCCHHHHH	36.75	26437602
305	Phosphorylation	AYLFCQRTFLSFIKT HHHHHHHHHHHHHHH	11.75	23186163
308	Phosphorylation	FCQRTFLSFIKTNRY HHHHHHHHHHHHCCC	22.27	24719451
353	Phosphorylation	HFLASRLSMKQHLDS HHHHHHHHHHHHHHH	23.87	23917254
531	Phosphorylation	IIVKKLPYLPRILGR EEEEECCCHHHHHCC	39.51	23532336
557	Phosphorylation	FMNHSITTLAKDTPL HHCCCHHHHCCCCCH	24.05	26503892
655	Phosphorylation	FKLLNLQSLFVTSRG HHHHCHHHEEEECCC	27.26	23403867
659	Phosphorylation	NLQSLFVTSRGRAVG CHHHEEEECCCCCCE	12.84	23403867
660	Phosphorylation	LQSLFVTSRGRAVGC HHHEEEECCCCCCEE	27.69	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLCKA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLCKA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLCKA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CLCKA_HUMAN !!

Drug and Disease Associations

Kegg Disease
H00239	Bartter syndrome
OMIM Disease
613090	Bartter syndrome 4B (BS4B)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB04552	Niflumic Acid

Regulatory Network of CLCKA_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660, AND MASSSPECTROMETRY.	17081983 [Abstract]