SLFN5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLFN5_HUMAN
• UniProt AC: Q08AF3
• Protein Name: Schlafen family member 5
• Gene Name: SLFN5
• Organism: Homo sapiens (Human).
• Sequence Length: 891
• Protein Description: May have a role in hematopoietic cell differentiation..
• Protein Sequence: MSLRIDVDTNFPECVVDAGKVTLGTQQRQEMDPRLREKQNEIILRAVCALLNSGGGIIKAEIENKGYNYERHGVGLDVPPIFRSHLDKMQKENHFLIFVKSWNTEAGVPLATLCSNLYHRERTSTDVMDSQEALAFLKCRTQTPTNINVSNSLGPQAAQGSVQYEGNINVSAAALFDRKRLQYLEKLNLPESTHVEFVMFSTDVSHCVKDRLPKCVSAFANTEGGYVFFGVHDETCQVIGCEKEKIDLTSLRASIDGCIKKLPVHHFCTQRPEIKYVLNFLEVHDKGALRGYVCAIKVEKFCCAVFAKVPSSWQVKDNRVRQLPTREWTAWMMEADPDLSRCPEMVLQLSLSSATPRSKPVCIHKNSECLKEQQKRYFPVFSDRVVYTPESLYKELFSQHKGLRDLINTEMRPFSQGILIFSQSWAVDLGLQEKQGVICDALLISQNNTPILYTIFSKWDAGCKGYSMIVAYSLKQKLVNKGGYTGRLCITPLVCVLNSDRKAQSVYSSYLQIYPESYNFMTPQHMEALLQSLVIVLLGFKSFLSEELGSEVLNLLTNKQYELLSKNLRKTRELFVHGLPGSGKTILALRIMEKIRNVFHCEPANILYICENQPLKKLVSFSKKNICQPVTRKTFMKNNFEHIQHIIIDDAQNFRTEDGDWYGKAKFITQTARDGPGVLWIFLDYFQTYHLSCSGLPPPSDQYPREEINRVVRNAGPIANYLQQVMQEARQNPPPNLPPGSLVMLYEPKWAQGVPGNLEIIEDLNLEEILIYVANKCRFLLRNGYSPKDIAVLFTKASEVEKYKDRLLTAMRKRKLSQLHEESDLLLQIGDASDVLTDHIVLDSVCRFSGLERNIVFGINPGVAPPAGAYNLLLCLASRAKRHLYILKASV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Ubiquitination	ECVVDAGKVTLGTQQ HHEEECCEEEECHHH	33.49	-
38	Acetylation	MDPRLREKQNEIILR CCHHHHHHHHHHHHH	52.57	25953088
38	Malonylation	MDPRLREKQNEIILR CCHHHHHHHHHHHHH	52.57	26320211
38	Ubiquitination	MDPRLREKQNEIILR CCHHHHHHHHHHHHH	52.57	-
59	Ubiquitination	NSGGGIIKAEIENKG HCCCCEEEEEEECCC	37.74	-
59	Sumoylation	NSGGGIIKAEIENKG HCCCCEEEEEEECCC	37.74	28112733
65 (in isoform 2)	Ubiquitination	-	50.40	21906983
65 (in isoform 1)	Ubiquitination	-	50.40	21906983
65	Ubiquitination	IKAEIENKGYNYERH EEEEEECCCCCCCCC	50.40	21906983
88	Acetylation	IFRSHLDKMQKENHF HHHHHHHHHHHCCCE	49.98	25953088
88	Ubiquitination	IFRSHLDKMQKENHF HHHHHHHHHHHCCCE	49.98	-
123	Phosphorylation	NLYHRERTSTDVMDS CHHCCCCCCCCCCCH	31.09	27251275
124	Phosphorylation	LYHRERTSTDVMDSQ HHCCCCCCCCCCCHH	28.91	27251275
125	Phosphorylation	YHRERTSTDVMDSQE HCCCCCCCCCCCHHH	31.81	27251275
138	Ubiquitination	QEALAFLKCRTQTPT HHHHHHHHCCCCCCC	18.41	-
245	Ubiquitination	VIGCEKEKIDLTSLR EEEEECCEECHHHHH	53.22	-
260	Ubiquitination	ASIDGCIKKLPVHHF HHHCHHHHHCCCCCE	52.94	-
261	Ubiquitination	SIDGCIKKLPVHHFC HHCHHHHHCCCCCEE	37.80	-
286	Ubiquitination	NFLEVHDKGALRGYV HEEECCCCCCCCCCE	31.07	-
300	Ubiquitination	VCAIKVEKFCCAVFA EEEEEEEEEEEEEEE	46.84	-
316	Ubiquitination	VPSSWQVKDNRVRQL CCCCEECCCCCEECC	33.90	-
365	Ubiquitination	SKPVCIHKNSECLKE CCCEEEECCHHHHHH	42.11	-
371	Acetylation	HKNSECLKEQQKRYF ECCHHHHHHHHHHHC	66.20	25953088
371	Ubiquitination	HKNSECLKEQQKRYF ECCHHHHHHHHHHHC	66.20	-
387	Phosphorylation	VFSDRVVYTPESLYK CCCCCEEECHHHHHH	17.45	25884760
393	Phosphorylation	VYTPESLYKELFSQH EECHHHHHHHHHHCC	16.22	25884760
394	Ubiquitination	YTPESLYKELFSQHK ECHHHHHHHHHHCCC	53.91	-
401	Ubiquitination	KELFSQHKGLRDLIN HHHHHCCCCHHHHHC	52.59	-
457	Phosphorylation	PILYTIFSKWDAGCK CCEEEEECCCCCCCC	29.05	24719451
473	Phosphorylation	YSMIVAYSLKQKLVN HHHEEEEECHHHHHH	21.25	24719451
481 (in isoform 1)	Ubiquitination	-	46.35	21906983
481	Ubiquitination	LKQKLVNKGGYTGRL CHHHHHHCCCCCCCE	46.35	2190698
559	Ubiquitination	VLNLLTNKQYELLSK HHHHHHHHHHHHHHH	49.36	-
566	Ubiquitination	KQYELLSKNLRKTRE HHHHHHHHHHHHHHH	61.03	-
584	Ubiquitination	HGLPGSGKTILALRI ECCCCCCHHHHHHHH	33.80	-
594	Ubiquitination	LALRIMEKIRNVFHC HHHHHHHHHHHHCCC	29.59	-
616	Malonylation	ICENQPLKKLVSFSK EECCCCHHHHHHCCC	51.23	26320211
616	Acetylation	ICENQPLKKLVSFSK EECCCCHHHHHHCCC	51.23	25953088
616	Ubiquitination	ICENQPLKKLVSFSK EECCCCHHHHHHCCC	51.23	-
617	Malonylation	CENQPLKKLVSFSKK ECCCCHHHHHHCCCC	62.90	26320211
617	Ubiquitination	CENQPLKKLVSFSKK ECCCCHHHHHHCCCC	62.90	-
620	Phosphorylation	QPLKKLVSFSKKNIC CCHHHHHHCCCCCCC	33.95	24719451
620	O-linked_Glycosylation	QPLKKLVSFSKKNIC CCHHHHHHCCCCCCC	33.95	27655845
622	Phosphorylation	LKKLVSFSKKNICQP HHHHHHCCCCCCCCC	34.90	30108239
623	Ubiquitination	KKLVSFSKKNICQPV HHHHHCCCCCCCCCC	48.07	-
623	Acetylation	KKLVSFSKKNICQPV HHHHHCCCCCCCCCC	48.07	25953088
623	Methylation	KKLVSFSKKNICQPV HHHHHCCCCCCCCCC	48.07	115980979
624	Ubiquitination	KLVSFSKKNICQPVT HHHHCCCCCCCCCCC	50.80	-
624	Methylation	KLVSFSKKNICQPVT HHHHCCCCCCCCCCC	50.80	115980987
637	Ubiquitination	VTRKTFMKNNFEHIQ CCHHHHHHCCHHHEE	44.54	-
656	O-linked_Glycosylation	DDAQNFRTEDGDWYG CCHHHCCCCCCCCCC	34.00	27655845
664	Ubiquitination	EDGDWYGKAKFITQT CCCCCCCEEEEEEEE	32.48	-
666	Ubiquitination	GDWYGKAKFITQTAR CCCCCEEEEEEEECC	40.56	-
796	Ubiquitination	DIAVLFTKASEVEKY HHEEEEECHHHHHHH	42.45	-
817	Phosphorylation	AMRKRKLSQLHEESD HHHHHHHHHHHHHCC	33.46	27251275
888	Ubiquitination	KRHLYILKASV---- HHEEEEEECCC----	29.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLFN5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLFN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLFN5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SLFN5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.