ANR35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANR35_HUMAN
• UniProt AC: Q8N283
• Protein Name: Ankyrin repeat domain-containing protein 35
• Gene Name: ANKRD35
• Organism: Homo sapiens (Human).
• Sequence Length: 1001
• Protein Sequence: MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSIKQDEEKEKRVPGARGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	SRKSARPTKLDSNGQ HCCCCCCCCCCCCCC	38.39	46164253
56	Phosphorylation	KLDSNGQSPFHLAAS CCCCCCCCHHHHHHC	30.82	27134283
207	Phosphorylation	EVAELLLSHGADAGA HHHHHHHHCCCCCCC	21.61	22210691
217	Phosphorylation	ADAGAVDSTGHDALH CCCCCCCCCCHHHHH	29.68	22210691
218	Phosphorylation	DAGAVDSTGHDALHY CCCCCCCCCHHHHHH	33.79	22210691
265	Phosphorylation	LASQASPSEPQAGSP HHCCCCCCCCCCCCC	60.45	28348404
271	Phosphorylation	PSEPQAGSPPKSSWR CCCCCCCCCCCCCCC	40.83	25849741
430	Phosphorylation	EEQGPPQSPASETIR HHHCCCCCCHHHHHH	28.36	27966365
514	Phosphorylation	DAARGALSRPVMEGA HHHCHHCCCHHHCCC	33.72	30576142
577	Phosphorylation	ALKAAPGSIKQDEEK HHHCCCCCCCCCHHH	26.08	113326733
623	Phosphorylation	EMSVLRLSNSNLLEE HHHHHHHCCCCHHHH	31.60	23403867
760	Phosphorylation	ENQQLRGSLSPCREP HHHHHCCCCCCCCCC	21.17	28450419
762	Phosphorylation	QQLRGSLSPCREPGT HHHCCCCCCCCCCCC	24.53	26657352
776	Phosphorylation	TSLKAPASPQVAALE CCCCCCCCHHHHHHH	18.14	28450419
838	Phosphorylation	SLRQHEKTRGSLVAQ HHHHHHHHHCHHHHH	36.96	27251275
841	Phosphorylation	QHEKTRGSLVAQAQA HHHHHHCHHHHHHHH	19.17	27251275
854	Ubiquitination	QAWGQELKALLEKYN HHHHHHHHHHHHHHH	35.91	-
881	Phosphorylation	VAEERRRSGDLAAQA HHHHHHHHCHHHHHH	34.54	27499020
896	Phosphorylation	AEQERQASEMRGRSE HHHHHHHHHHCCCHH	24.48	8219801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANR35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANR35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANR35_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ANR35_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.