| UniProt ID | TM11A_HUMAN | |
|---|---|---|
| UniProt AC | Q6ZMR5 | |
| Protein Name | Transmembrane protease serine 11A | |
| Gene Name | TMPRSS11A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 421 | |
| Subcellular Localization |
Membrane Single-pass type II membrane protein . |
|
| Protein Description | Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.. | |
| Protein Sequence | MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDPQINNNFGQSNTYQLKDLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | YRTVGFGTRSRNLKP CCEECCCCCCCCCHH | 24.18 | 30619164 | |
| 12 | Phosphorylation | TVGFGTRSRNLKPWM EECCCCCCCCCHHHH | 25.92 | 30619164 | |
| 81 (in isoform 2) | Phosphorylation | - | 20.37 | 21712546 | |
| 92 (in isoform 2) | Phosphorylation | - | 4.83 | 21712546 | |
| 95 | Phosphorylation | VDEIFIDSAWKKNYI HHHHHCCCHHHHHHC | 31.08 | - | |
| 156 | N-linked_Glycosylation | NLRALPINASSVQVN HCCCCCCCCCEEEEE | 31.65 | UniProtKB CARBOHYD | |
| 306 | N-linked_Glycosylation | ASASFQPNLTVHITG HHHCCCCCEEEEEEE | 37.25 | UniProtKB CARBOHYD | |
| 377 | Phosphorylation | DSGGPLVTRDLKDTW CCCCCCCCCCCCCCE | 26.58 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TM11A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TM11A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TM11A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZBT17_HUMAN | ZBTB17 | physical | 15095404 | |
| SPB6_HUMAN | SERPINB6 | physical | 26186194 | |
| PAK4_HUMAN | PAK4 | physical | 26186194 | |
| ACADL_HUMAN | ACADL | physical | 26186194 | |
| RSPRY_HUMAN | RSPRY1 | physical | 26186194 | |
| PSG3_HUMAN | PSG3 | physical | 26186194 | |
| TMM11_HUMAN | TMEM11 | physical | 26186194 | |
| ACADL_HUMAN | ACADL | physical | 28514442 | |
| PSG3_HUMAN | PSG3 | physical | 28514442 | |
| RSPRY_HUMAN | RSPRY1 | physical | 28514442 | |
| TMM11_HUMAN | TMEM11 | physical | 28514442 | |
| PAK4_HUMAN | PAK4 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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