ACADL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACADL_HUMAN
• UniProt AC: P28330
• Protein Name: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
• Gene Name: ACADL
• Organism: Homo sapiens (Human).
• Sequence Length: 430
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	QLPAARCSHSGGEER CCCCCCCCCCCCCCC	18.35	101544913
30	Phosphorylation	PAARCSHSGGEERLE CCCCCCCCCCCCCCC	32.00	29116813
38	Phosphorylation	GGEERLETPSAKKLT CCCCCCCCCCCCCCC	27.43	29116813
40	Phosphorylation	EERLETPSAKKLTDI CCCCCCCCCCCCCHH	61.20	29116813
42	Acetylation	RLETPSAKKLTDIGI CCCCCCCCCCCHHCH	53.29	20203611
54	Phosphorylation	IGIRRIFSPEHDIFR HCHHHHCCCCHHHHH	27.32	-
66	Succinylation	IFRKSVRKFFQEEVI HHHHHHHHHHHHCCC	48.66	-
66	Acetylation	IFRKSVRKFFQEEVI HHHHHHHHHHHHCCC	48.66	-
66	Succinylation	IFRKSVRKFFQEEVI HHHHHHHHHHHHCCC	48.66	-
81	Succinylation	PHHSEWEKAGEVSRE CCCHHHHHHCHHHHH	63.87	-
81	Succinylation	PHHSEWEKAGEVSRE CCCHHHHHHCHHHHH	63.87	-
81	Acetylation	PHHSEWEKAGEVSRE CCCHHHHHHCHHHHH	63.87	-
92	Acetylation	VSREVWEKAGKQGLL HHHHHHHHHHHCCCC	46.88	-
95	Acetylation	EVWEKAGKQGLLGVN HHHHHHHHCCCCCCC	46.16	-
155	Acetylation	HGSEEQIKHFIPQMT CCCHHHHHHHHHHCC	31.96	20203611
162	Phosphorylation	KHFIPQMTAGKCIGA HHHHHHCCCCCEEEE	27.32	46157371
165	Succinylation	IPQMTAGKCIGAIAM HHHCCCCCEEEEEEE	21.88	-
165	Succinylation	IPQMTAGKCIGAIAM HHHCCCCCEEEEEEE	21.88	-
189	Acetylation	QGIKTNAKKDGSDWI CCCCCCCCCCCCCEE	54.16	20167786
193	Phosphorylation	TNAKKDGSDWILNGS CCCCCCCCCEEECCC	39.65	21130716
200	Phosphorylation	SDWILNGSKVFISNG CCEEECCCEEEEECC	25.27	21130716
240	Acetylation	FLVENGMKGFIKGRK EEEECCCCCEECCCH	52.66	20203611
240	Succinylation	FLVENGMKGFIKGRK EEEECCCCCEECCCH	52.66	-
240	Succinylation	FLVENGMKGFIKGRK EEEECCCCCEECCCH	52.66	-
254	Acetylation	KLHKMGLKAQDTAEL HHHHCCCCCHHHHHH	37.97	20203611
254	Succinylation	KLHKMGLKAQDTAEL HHHHCCCCCHHHHHH	37.97	-
254	Succinylation	KLHKMGLKAQDTAEL HHHHCCCCCHHHHHH	37.97	-
271	Phosphorylation	EDIRLPASALLGEEN HHCCCCHHHHHCCCC	19.94	50563019
279	Succinylation	ALLGEENKGFYYIMK HHHCCCCCCCHHCCC	54.39	-
279	Succinylation	ALLGEENKGFYYIMK HHHCCCCCCCHHCCC	54.39	-
279	Acetylation	ALLGEENKGFYYIMK HHHCCCCCCCHHCCC	54.39	-
318	Acetylation	RNYVKQRKAFGKTVA HHHHHHHHHHCHHHH	45.64	20203611
322	Succinylation	KQRKAFGKTVAHLQT HHHHHHCHHHHHHHH	33.11	-
322	Acetylation	KQRKAFGKTVAHLQT HHHHHHCHHHHHHHH	33.11	20203611
322	Succinylation	KQRKAFGKTVAHLQT HHHHHHCHHHHHHHH	33.11	-
329	Phosphorylation	KTVAHLQTVQHKLAE HHHHHHHHHHHHHHH	28.61	46157377
351	S-palmitoylation	TRAFVDNCLQLHEAK HHHHHHHHHHHHHHH	1.91	21044946
358	Acetylation	CLQLHEAKRLDSATA HHHHHHHHHHHHHHH	50.97	20203611
362	Phosphorylation	HEAKRLDSATACMAK HHHHHHHHHHHHHHH	31.92	-
402	Phosphorylation	EYPIAKAYVDARVQP CCCCCCHHHCCCCCC	9.73	23663014
411	Phosphorylation	DARVQPIYGGTNEIM CCCCCCCCCCHHHHH	19.04	6877357

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACADL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
318	K	Acetylation	Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity.	-
322	K	Acetylation	Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
329	Phosphorylation	333 (4)	K ⇒ Q	rs2286963	Metabolite levels Acylcarnitine levels	20037589 26068415

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYT2_HUMAN	SYT2	physical	26186194
SYT2_HUMAN	SYT2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 201475: Acyl-CoA dehydrogenase very long-chain deficiency (ACADVLD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.