SYT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT2_HUMAN
• UniProt AC: Q8N9I0
• Protein Name: Synaptotagmin-2 {ECO:0000305}
• Gene Name: SYT2 {ECO:0000312|HGNC:HGNC:11510}
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Synaptic vesicles and chromaffin granules..
• Protein Description: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes. [PubMed: 23999003]
• Protein Sequence: MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	N-linked_Glycosylation	MPIGPVDNSTESGGA CCCCCCCCCCCCCCC	51.57	UniProtKB CARBOHYD
46	Acetylation	SQEDMFAKLKEKLFN CHHHHHHHHHHHHHH	49.15	7460707
48	Acetylation	EDMFAKLKEKLFNEI HHHHHHHHHHHHHHH	52.69	7460717
98	Ubiquitination	KKKNKKEKGKGMKNA CCCCHHHCCHHHHHC	74.85	-
122	Phosphorylation	QDDDDAETGLTEGEG CCCCHHHCCCCCCCC	38.93	18510355
125	Phosphorylation	DDAETGLTEGEGEGE CHHHCCCCCCCCCCC	43.20	18510355
178	Phosphorylation	MGGTSDPYVKVFLLP CCCCCCCCEEEEECC	20.21	25884760
199	Phosphorylation	ETKVHRKTLNPAFNE CCCCCCCCCCHHHCC	31.55	30631047
207	Phosphorylation	LNPAFNETFTFKVPY CCHHHCCCEEEEEEH	29.13	30631047
209	Phosphorylation	PAFNETFTFKVPYQE HHHCCCEEEEEEHHH	29.93	30631047
227	Phosphorylation	KTLVMAIYDFDRFSK EEEEEEEEECCCCCC	10.87	-
234	Ubiquitination	YDFDRFSKHDIIGEV EECCCCCCCCEEEEE	42.45	32142685
277	Phosphorylation	KLGDICTSLRYVPTA HHHHHHHHCCCCCCC	13.36	23403867
299	Acetylation	LEAKNLKKMDVGGLS EECCCCCCCCCCCCC	43.42	30592783
309	Phosphorylation	VGGLSDPYVKIHLMQ CCCCCCCHHHHEEHH	21.26	25884760
319	Ubiquitination	IHLMQNGKRLKKKKT HEEHHCCCCCCCCCC	63.21	30230243
332	Phosphorylation	KTTVKKKTLNPYFNE CCCCCEECCCCCCCC	40.42	28111955
336	Phosphorylation	KKKTLNPYFNESFSF CEECCCCCCCCCEEE	20.26	28111955
340	Phosphorylation	LNPYFNESFSFEIPF CCCCCCCCEEEECCH	27.56	28111955
342	Phosphorylation	PYFNESFSFEIPFEQ CCCCCCEEEECCHHH	31.11	28111955
362	Phosphorylation	VVVTVLDYDKLGKNE EEEEECCHHHCCCCC	15.71	21082442
378	Phosphorylation	IGKIFVGSNATGTEL CEEEEEECCCCCCCH	20.28	-
381	Phosphorylation	IFVGSNATGTELRHW EEEECCCCCCCHHHH	49.22	-
383	Phosphorylation	VGSNATGTELRHWSD EECCCCCCCHHHHHH	27.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRPQ_HUMAN	SYNCRIP	physical	10734137

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616040: Myasthenic syndrome, congenital, 7, presynaptic (CMS7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00042: Botulinum Toxin Type B