SPB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPB6_HUMAN
• UniProt AC: P35237
• Protein Name: Serpin B6
• Gene Name: SERPINB6
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm .
• Protein Description: May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss..
• Protein Sequence: MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDVLAEAN -------CCHHHHCC	7.89	22223895
10	Phosphorylation	VLAEANGTFALNLLK HHHHCCCHHHHHHHH	12.92	22210691
24	Phosphorylation	KTLGKDNSKNVFFSP HHHCCCCCCCCCCCC	35.42	22210691
42	Phosphorylation	SCALAMVYMGAKGNT HHHHHHHHHCCCCCH	4.09	-
49	Phosphorylation	YMGAKGNTAAQMAQI HHCCCCCHHHHHHHH	31.85	21712546
58	Phosphorylation	AQMAQILSFNKSGGG HHHHHHHCCCCCCCC	28.53	21712546
62	Phosphorylation	QILSFNKSGGGGDIH HHHCCCCCCCCCCHH	43.72	20873877
68	Phosphorylation	KSGGGGDIHQGFQSL CCCCCCCHHHHHHHH	2.71	-
77	Phosphorylation	QGFQSLLTEVNKTGT HHHHHHHHHHHHHHH	43.08	-
80	Ubiquitination	QSLLTEVNKTGTQYL HHHHHHHHHHHHHHH	29.91	-
81	Phosphorylation	SLLTEVNKTGTQYLL HHHHHHHHHHHHHHH	54.21	27251275
86	Phosphorylation	VNKTGTQYLLRMANR HHHHHHHHHHHHHHH	13.93	28152594
89	Methylation	TGTQYLLRMANRLFG HHHHHHHHHHHHHHC	21.41	-
93	Methylation	YLLRMANRLFGEKSC HHHHHHHHHHCCCCH	23.12	115916489
98	Acetylation	ANRLFGEKSCDFLSS HHHHHCCCCHHHHHH	57.68	26051181
98	Ubiquitination	ANRLFGEKSCDFLSS HHHHHCCCCHHHHHH	57.68	-
99	Phosphorylation	NRLFGEKSCDFLSSF HHHHCCCCHHHHHHH	18.02	21712546
104	Phosphorylation	EKSCDFLSSFRDSCQ CCCHHHHHHHHHHHH	27.68	21815630
105	Phosphorylation	KSCDFLSSFRDSCQK CCHHHHHHHHHHHHH	26.84	25627689
108	Methylation	DFLSSFRDSCQKFYQ HHHHHHHHHHHHHHH	52.32	-
112	Methylation	SFRDSCQKFYQAEME HHHHHHHHHHHHHHH	50.82	-
118	Phosphorylation	QKFYQAEMEELDFIS HHHHHHHHHHHHHHH	5.63	-
124	Phosphorylation	EMEELDFISAVEKSR HHHHHHHHHHHHHHH	2.29	27251275
125	Phosphorylation	MEELDFISAVEKSRK HHHHHHHHHHHHHHH	26.67	30257219
129	Ubiquitination	DFISAVEKSRKHINT HHHHHHHHHHHHHHH	49.30	-
132	Malonylation	SAVEKSRKHINTWVA HHHHHHHHHHHHHHH	56.80	26320211
132	Acetylation	SAVEKSRKHINTWVA HHHHHHHHHHHHHHH	56.80	26051181
141	Acetylation	INTWVAEKTEGKIAE HHHHHHHCCCCCHHH	41.98	27452117
142	Phosphorylation	NTWVAEKTEGKIAEL HHHHHHCCCCCHHHH	41.28	22210691
148	Ubiquitination	KTEGKIAELLSPGSV CCCCCHHHHCCCCCC	54.43	-
151	Ubiquitination	GKIAELLSPGSVDPL CCHHHHCCCCCCCHH	39.58	-
151	Phosphorylation	GKIAELLSPGSVDPL CCHHHHCCCCCCCHH	39.58	29255136
154	Phosphorylation	AELLSPGSVDPLTRL HHHCCCCCCCHHHHH	27.08	23403867
159	Phosphorylation	PGSVDPLTRLVLVNA CCCCCHHHHHHEEEE	27.61	23403867
160	Ubiquitination	GSVDPLTRLVLVNAV CCCCHHHHHHEEEEE	30.40	-
168	Phosphorylation	LVLVNAVYFRGNWDE HHEEEEEEECCCCCH	5.78	22210691
170	Phosphorylation	LVNAVYFRGNWDEQF EEEEEEECCCCCHHC	21.61	18669648
179	Acetylation	NWDEQFDKENTEERL CCCHHCCCCCHHHHH	54.90	26051181
179	Ubiquitination	NWDEQFDKENTEERL CCCHHCCCCCHHHHH	54.90	21890473
182	Phosphorylation	EQFDKENTEERLFKV HHCCCCCHHHHHHHC	40.07	24275569
190	Phosphorylation	EERLFKVSKNEEKPV HHHHHHCCCCCCCCC	30.29	26437602
195	Acetylation	KVSKNEEKPVQMMFK HCCCCCCCCCEEEEC	44.29	-
198	Ubiquitination	KNEEKPVQMMFKQST CCCCCCCEEEECHHC	26.59	-
199	Sulfoxidation	NEEKPVQMMFKQSTF CCCCCCEEEECHHCC	3.29	30846556
200	Sulfoxidation	EEKPVQMMFKQSTFK CCCCCEEEECHHCCC	1.81	30846556
201	Phosphorylation	EKPVQMMFKQSTFKK CCCCEEEECHHCCCC	5.67	-
209	Phosphorylation	KQSTFKKTYIGEIFT CHHCCCCHHHHHHHH	22.44	22210691
210	Phosphorylation	QSTFKKTYIGEIFTQ HHCCCCHHHHHHHHH	18.79	22210691
216	Phosphorylation	TYIGEIFTQILVLPY HHHHHHHHHHHHHHH	21.99	22210691
223	Phosphorylation	TQILVLPYVGKELNM HHHHHHHHCCCCEEE	20.06	22210691
227	Ubiquitination	VLPYVGKELNMIIML HHHHCCCCEEEEEEC	39.17	-
230	Sulfoxidation	YVGKELNMIIMLPDE HCCCCEEEEEECCCC	3.25	30846556
233	Sulfoxidation	KELNMIIMLPDETTD CCEEEEEECCCCCCC	2.84	30846556
238	Phosphorylation	IIMLPDETTDLRTVE EEECCCCCCCCHHHH	32.75	25072903
239	Phosphorylation	IMLPDETTDLRTVEK EECCCCCCCCHHHHH	30.87	25072903
246	Acetylation	TDLRTVEKELTYEKF CCCHHHHHHHHHHHH	54.40	26051181
246	Malonylation	TDLRTVEKELTYEKF CCCHHHHHHHHHHHH	54.40	26320211
250	Phosphorylation	TVEKELTYEKFVEWT HHHHHHHHHHHHHCC	29.73	-
252	Ubiquitination	EKELTYEKFVEWTRL HHHHHHHHHHHCCCC	44.27	21890473
252	Acetylation	EKELTYEKFVEWTRL HHHHHHHHHHHCCCC	44.27	11921057
252	Ubiquitination	EKELTYEKFVEWTRL HHHHHHHHHHHCCCC	44.27	21890473
261	Sulfoxidation	VEWTRLDMMDEEEVE HHCCCCCCCCHHHHE	4.28	30846556
262	Sulfoxidation	EWTRLDMMDEEEVEV HCCCCCCCCHHHHEE	6.15	30846556
265	Ubiquitination	RLDMMDEEEVEVSLP CCCCCCHHHHEEECC	64.18	-
270	Phosphorylation	DEEEVEVSLPRFKLE CHHHHEEECCCCCCC	21.10	24719451
271	Ubiquitination	EEEVEVSLPRFKLEE HHHHEEECCCCCCCC	4.22	-
279	Phosphorylation	PRFKLEESYDMESVL CCCCCCCCCCHHHHH	19.63	23663014
280	Phosphorylation	RFKLEESYDMESVLR CCCCCCCCCHHHHHH	23.69	23663014
282	Sulfoxidation	KLEESYDMESVLRNL CCCCCCCHHHHHHHC	2.92	30846556
284	Phosphorylation	EESYDMESVLRNLGM CCCCCHHHHHHHCCC	21.58	23663014
285	Ubiquitination	ESYDMESVLRNLGMT CCCCHHHHHHHCCCC	3.57	21890473
285	Ubiquitination	ESYDMESVLRNLGMT CCCCHHHHHHHCCCC	3.57	21890473
285	Ubiquitination	ESYDMESVLRNLGMT CCCCHHHHHHHCCCC	3.57	21890473
303	Phosphorylation	ELGKADFSGMSQTDL HHCCCCCCCCCHHHH	33.85	30622161
305	Sulfoxidation	GKADFSGMSQTDLSL CCCCCCCCCHHHHCH	2.32	30846556
306	Phosphorylation	KADFSGMSQTDLSLS CCCCCCCCHHHHCHH	33.19	25159151
308	Phosphorylation	DFSGMSQTDLSLSKV CCCCCCHHHHCHHHH	31.44	30622161
311	Phosphorylation	GMSQTDLSLSKVVHK CCCHHHHCHHHHHHH	33.15	24719451
314	Ubiquitination	QTDLSLSKVVHKSFV HHHHCHHHHHHHHHE	54.28	21890473
314	Acetylation	QTDLSLSKVVHKSFV HHHHCHHHHHHHHHE	54.28	27452117
314	Ubiquitination	QTDLSLSKVVHKSFV HHHHCHHHHHHHHHE	54.28	21890473
325	Phosphorylation	KSFVEVNEEGTEAAA HHHEEECCCHHHHHH	64.08	-
333	Ubiquitination	EGTEAAAATAAIMMM CHHHHHHHHHHHHHH	7.95	-
347	Ubiquitination	MRCARFVPRFCADHP HHHHHHHHHHHCCCC	22.40	21890473
347	Ubiquitination	MRCARFVPRFCADHP HHHHHHHHHHHCCCC	22.40	21890473
347	Ubiquitination	MRCARFVPRFCADHP HHHHHHHHHHHCCCC	22.40	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THRB_HUMAN	F2	physical	8415716
ITPA_HUMAN	ITPA	physical	26344197
XYLB_HUMAN	XYLB	physical	26344197
SPB8_HUMAN	SERPINB8	physical	28514442
TPA_HUMAN	PLAT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613453: Deafness, autosomal recessive, 91 (DFNB91)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00055: Drotrecogin alfa