XYLB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XYLB_HUMAN
• UniProt AC: O75191
• Protein Name: Xylulose kinase
• Gene Name: XYLB
• Organism: Homo sapiens (Human).
• Sequence Length: 536
• Protein Description: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis..
• Protein Sequence: MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Ubiquitination	EESVHFDRDLPEFGT EECCCCCCCCHHHCC	46.55	-
41	Ubiquitination	EESVHFDRDLPEFGT EECCCCCCCCHHHCC	46.55	21890473
112	Ubiquitination	KAGAQQALTSLSPDL ECCHHHHHHHCCCCC	2.65	21890473
178	Ubiquitination	FTGNQIAKIYQQNPE HCHHHHHHHHHHCHH	43.50	21890473
178	Ubiquitination	FTGNQIAKIYQQNPE HCHHHHHHHHHHCHH	43.50	21906983
180	Phosphorylation	GNQIAKIYQQNPEAY HHHHHHHHHHCHHHH	11.88	29496907
187	Phosphorylation	YQQNPEAYSHTERIS HHHCHHHHCCHHHHH	10.18	27642862
282	Ubiquitination	VAFTGDNPASLAGMR EEEECCCHHHHCCCE	28.15	-
288	Sulfoxidation	NPASLAGMRLEEGDI CHHHHCCCEECCCCE	3.53	21406390
298	Ubiquitination	EEGDIAVSLGTSDTL CCCCEEEEECCCCEE	16.44	-
350	Phosphorylation	REKIRNESVSRSWSD HHHHHCCCHHCCHHH	29.01	26699800
352	Phosphorylation	KIRNESVSRSWSDFS HHHCCCHHCCHHHHH	29.85	26699800
354	Phosphorylation	RNESVSRSWSDFSKA HCCCHHCCHHHHHHH	24.35	28857561
356	Phosphorylation	ESVSRSWSDFSKALQ CCHHCCHHHHHHHHH	29.98	23186163
357	Ubiquitination	SVSRSWSDFSKALQS CHHCCHHHHHHHHHH	45.65	-
359	Phosphorylation	SRSWSDFSKALQSTE HCCHHHHHHHHHHCC	23.24	23186163
394	Phosphorylation	IGRHRFNTENHKVAA HCCCCCCCCCCEEEE	35.14	-
419	Ubiquitination	IEGQFMAKRIHAEGL HCCCHHHHCHHHCCC	39.85	-
419	Acetylation	IEGQFMAKRIHAEGL HCCCHHHHCHHHCCC	39.85	7303055
428	Phosphorylation	IHAEGLGYRVMSKTK HHHCCCCEEEEECCE	12.70	28634298
432	Phosphorylation	GLGYRVMSKTKILAT CCCEEEEECCEEEEE	34.02	26437602
433	Acetylation	LGYRVMSKTKILATG CCEEEEECCEEEEEC	35.42	7303065
434	Phosphorylation	GYRVMSKTKILATGG CEEEEECCEEEEECC	18.93	26437602
435	Ubiquitination	YRVMSKTKILATGGA EEEEECCEEEEECCC	39.19	29967540
490	Phosphorylation	GGTDVPFSEVVKLAP CCCCCCHHHHHHCCC	24.34	29083192
494	Ubiquitination	VPFSEVVKLAPNPRL CCHHHHHHCCCCCCE	44.07	-
506	Phosphorylation	PRLAATPSPGASQVY CCEECCCCCCHHHHH	31.45	24719451
513	Phosphorylation	SPGASQVYEALLPQY CCCHHHHHHHHHHHH	6.45	-
520	Phosphorylation	YEALLPQYAKLEQRI HHHHHHHHHHHHHHH	12.08	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of XYLB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XYLB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XYLB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPE_HUMAN	RPE	physical	26344197
SCRN2_HUMAN	SCRN2	physical	26344197
TALDO_HUMAN	TALDO1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.