SCRN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCRN2_HUMAN
• UniProt AC: Q96FV2
• Protein Name: Secernin-2
• Gene Name: SCRN2
• Organism: Homo sapiens (Human).
• Sequence Length: 425
• Protein Sequence: MASSSPDSPCSCDCFVSVPPASAIPAVIFAKNSDRPRDEVQEVVFVPAGTHTPGSRLQCTYIEVEQVSKTHAVILSRPSWLWGAEMGANEHGVCIGNEAVWTKEPVGEGEALLGMDLLRLALERSSSAQEALHVITGLLEHYGQGGNCLEDAAPFSYHSTFLLADRTEAWVLETAGRLWAAQRIQEGARNISNQLSIGTDISAQHPELRTHAQAKGWWDGQGAFDFAQIFSLTQQPVRMEAAKARFQAGRELLRQRQGGITAEVMMGILRDKESGICMDSGGFRTTASMVSVLPQDPTQPCVHFLTATPDPSRSVFKPFIFGMGVAQAPQVLSPTFGAQDPVRTLPRFQTQVDRRHTLYRGHQAALGLMERDQDRGQQLQQKQQDLEQEGLEATQGLLAGEWAPPLWELGSLFQAFVKRESQAYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASSSPDSPC -----CCCCCCCCCC	30.01	28348404
4	Phosphorylation	----MASSSPDSPCS ----CCCCCCCCCCC	36.03	28348404
5	Phosphorylation	---MASSSPDSPCSC ---CCCCCCCCCCCC	30.17	28348404
8	Phosphorylation	MASSSPDSPCSCDCF CCCCCCCCCCCCCEE	31.06	28348404
11	Phosphorylation	SSPDSPCSCDCFVSV CCCCCCCCCCEEEEC	19.17	28348404
17	Phosphorylation	CSCDCFVSVPPASAI CCCCEEEECCCHHHC	14.51	28348404
33	Phosphorylation	AVIFAKNSDRPRDEV EEEEECCCCCCCHHC	34.00	27251275
50	Phosphorylation	VVFVPAGTHTPGSRL EEEECCCCCCCCCCE	25.36	23898821
52	Phosphorylation	FVPAGTHTPGSRLQC EECCCCCCCCCCEEE	29.23	30266825
55	Phosphorylation	AGTHTPGSRLQCTYI CCCCCCCCCEEEEEE	30.90	30266825
115	Sulfoxidation	EGEALLGMDLLRLAL CCHHHHHHHHHHHHH	3.11	21406390
196	Phosphorylation	RNISNQLSIGTDISA HHHHHHHCCCCCCHH	14.81	-
272	Ubiquitination	MMGILRDKESGICMD HHHHHCCCCCCEEEC	47.55	-
274	Phosphorylation	GILRDKESGICMDSG HHHCCCCCCEEECCC	38.92	-
278	Sulfoxidation	DKESGICMDSGGFRT CCCCCEEECCCCCCC	4.31	21406390
280	Phosphorylation	ESGICMDSGGFRTTA CCCEEECCCCCCCCC	17.58	-
350	Phosphorylation	RTLPRFQTQVDRRHT CCCCCHHHHCHHCHH	28.04	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCRN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCRN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCRN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCC2D_HUMAN	CAMK2D	physical	26186194
CCS_HUMAN	CCS	physical	26186194
XRN1_HUMAN	XRN1	physical	26186194
F122B_HUMAN	FAM122B	physical	26186194
DCA10_HUMAN	DCAF10	physical	26186194
PRC2B_HUMAN	PRRC2B	physical	26186194
KCTD3_HUMAN	KCTD3	physical	26186194
CCS_HUMAN	CCS	physical	28514442
F122B_HUMAN	FAM122B	physical	28514442
XRN1_HUMAN	XRN1	physical	28514442
PRC2B_HUMAN	PRRC2B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.