CCS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCS_HUMAN
• UniProt AC: O14618
• Protein Name: Copper chaperone for superoxide dismutase
• Gene Name: CCS
• Organism: Homo sapiens (Human).
• Sequence Length: 274
• Subcellular Localization: Cytoplasm .
• Protein Description: Delivers copper to copper zinc superoxide dismutase (SOD1)..
• Protein Sequence: MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Ubiquitination	TGRQAVLKGMGSGQL CCHHHHHCCCCCHHH	40.01	20154138
109	Phosphorylation	VVRFLQLTPERCLIE HHHHHHCCCCCEEEE	15.33	26270265
165	Methylation	PQDSDRHRGDLGNVR CCCCCCCCCCCCCCE	41.01	-
189	Ubiquitination	RMEDEQLKVWDVIGR EECHHHHEEEEEECC	40.76	20154138
209	Methylation	EGEDDLGRGGHPLSK CCCCCCCCCCCCCHH	56.04	-
216	Ubiquitination	RGGHPLSKITGNSGE CCCCCCHHHCCCCCC	52.55	20154138
241	Ubiquitination	AGLFQNPKQICSCDG CCCCCCHHHEECCCC	60.90	2015413
245	Phosphorylation	QNPKQICSCDGLTIW CCHHHEECCCCEEEE	19.51	28348404
267	Phosphorylation	AGKGRKESAQPPAHL CCCCCHHCCCCCCCC	34.93	15736924

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	XIAP	P98170	PMID:19948006

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
241	K	ubiquitylation	XIAP/BIRC4 preferentially ubiquitinates at Lys-241.	20154138

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SODC_HUMAN	SOD1	physical	9726962
APBA1_HUMAN	APBA1	physical	11115513
CCS_HUMAN	CCS	physical	10677207
XIAP_HUMAN	XIAP	physical	20154138
SODC_HUMAN	SOD1	physical	12968035
ATOX1_HUMAN	ATOX1	physical	26344197
PPIL3_HUMAN	PPIL3	physical	26344197
RAE1L_HUMAN	RAE1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.
PubMed: 17287340

Ubiquitylation

"Regulation of the copper chaperone CCS by XIAP-mediatedubiquitination.";
Brady G.F., Galban S., Liu X., Basrur V., Gitlin J.D.,Elenitoba-Johnson K.S., Wilson T.E., Duckett C.S.;
Mol. Cell. Biol. 30:1923-1936(2010).
Cited for: UBIQUITINATION AT LYS-76; LYS-189; LYS-216 AND LYS-241 BY XIAP/BIRC4,AND INTERACTION WITH XIAP/BIRC4.
PubMed: 20154138