APBA1_HUMAN - dbPTM
APBA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID APBA1_HUMAN
UniProt AC Q02410
Protein Name Amyloid-beta A4 precursor protein-binding family A member 1
Gene Name APBA1
Organism Homo sapiens (Human).
Sequence Length 837
Subcellular Localization Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Only about 5% of the protein is located in the nucleus.
Isoform 2: Golgi apparatus .
Protein Description Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta..
Protein Sequence MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDLRAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAVQYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGEDEPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
78PhosphorylationRGECLARSASTESGF
HHCCCCHHCCCCCCC		22.4426846344
80PhosphorylationECLARSASTESGFHN
CCCCHHCCCCCCCCC		33.6726846344
81PhosphorylationCLARSASTESGFHNH
CCCHHCCCCCCCCCC		33.6126846344
83PhosphorylationARSASTESGFHNHTD
CHHCCCCCCCCCCCC		47.0126846344
89PhosphorylationESGFHNHTDTAEGDV
CCCCCCCCCCCCCCE		40.1226846344
91PhosphorylationGFHNHTDTAEGDVIA
CCCCCCCCCCCCEEE		27.9726846344
116PhosphorylationAQDPEDESAYAVQYR
HCCCCCCCCCEEEEC		38.6128796482
118PhosphorylationDPEDESAYAVQYRPE
CCCCCCCCEEEECHH		19.3128796482
122PhosphorylationESAYAVQYRPEAEEY
CCCCEEEECHHHHHH		22.8728796482
129PhosphorylationYRPEAEEYTEQAEAE
ECHHHHHHHHHHHHH		13.6928796482
130PhosphorylationRPEAEEYTEQAEAEH
CHHHHHHHHHHHHHH		25.5428796482
154PhosphorylationPNHLHFHSLEHEEAM
CCCEEECCCCHHHHH		34.21-
165PhosphorylationEEAMNAAYSGYVYTH
HHHHHHHHCCCHHEE		10.54-
166PhosphorylationEAMNAAYSGYVYTHR
HHHHHHHCCCHHEEE		20.9425884760
168PhosphorylationMNAAYSGYVYTHRLF
HHHHHCCCHHEEECC		5.59-
170PhosphorylationAAYSGYVYTHRLFHR
HHHCCCHHEEECCCC		6.5825884760
171PhosphorylationAYSGYVYTHRLFHRG
HHCCCHHEEECCCCC		7.17-
183PhosphorylationHRGEDEPYSEPYADY
CCCCCCCCCCCCCCC		24.50-
184PhosphorylationRGEDEPYSEPYADYG
CCCCCCCCCCCCCCC		42.6927642862
187PhosphorylationDEPYSEPYADYGGLQ
CCCCCCCCCCCCHHH		14.1927642862
190PhosphorylationYSEPYADYGGLQEHV
CCCCCCCCCHHHHHH		12.62-
198PhosphorylationGGLQEHVYEEIGDAP
CHHHHHHHHHHCCCC		15.1127642862
216PhosphorylationARDGLRLYEQERDEA
HHCCCCHHHHHHHHH		14.7727642862
226PhosphorylationERDEAAAYRQEALGA
HHHHHHHHHHHHHHH		14.22-
238PhosphorylationLGARLHHYDERSDGE
HHHHHCCCCCCCCCC		14.5720363803
242PhosphorylationLHHYDERSDGESDSP
HCCCCCCCCCCCCCH		48.1725072903
246PhosphorylationDERSDGESDSPEKEA
CCCCCCCCCCHHHHH		49.2525072903
248PhosphorylationRSDGESDSPEKEAEF
CCCCCCCCHHHHHHC		44.2125072903
258PhosphorylationKEAEFAPYPRMDSYE
HHHHCCCCCCCCCCC		10.4729978859
263PhosphorylationAPYPRMDSYEQEEDI
CCCCCCCCCCCCCCH		22.6422617229
264PhosphorylationPYPRMDSYEQEEDID
CCCCCCCCCCCCCHH		19.8425884760
280PhosphorylationIVAEVKQSMSSQSLD
HHHHHHHHHCHHHHH		18.21-
282PhosphorylationAEVKQSMSSQSLDKA
HHHHHHHCHHHHHHH		30.3920363803
283PhosphorylationEVKQSMSSQSLDKAA
HHHHHHCHHHHHHHH		18.3628348404
285PhosphorylationKQSMSSQSLDKAAED
HHHHCHHHHHHHHHH		40.2520363803
305PhosphorylationQDLERPPTPAGGRPD
HHHCCCCCCCCCCCC		28.5826657352
313PhosphorylationPAGGRPDSPGLQAPA
CCCCCCCCCCCCCCC		24.4526657352
339PhosphorylationGEAGQRYSKEKRDAI
CHHHHHCCHHHHHHH		36.2128348404
347PhosphorylationKEKRDAISLAIKDIK
HHHHHHHHHHHHHHH		17.3023312004
364PhosphorylationIEEVKTRTIRSPYTP
HHHHHHCCCCCCCCC		26.4428348404
367PhosphorylationVKTRTIRSPYTPDEP
HHHCCCCCCCCCCCC		20.5727732954
369PhosphorylationTRTIRSPYTPDEPKE
HCCCCCCCCCCCCCC		31.9528857561
370PhosphorylationRTIRSPYTPDEPKEP
CCCCCCCCCCCCCCC		27.8728857561
386PhosphorylationWVMRQDISPTRDCDD
EEEECCCCCCCCCCC		28.6326699800
388PhosphorylationMRQDISPTRDCDDQR
EECCCCCCCCCCCCC		32.1425307156
401PhosphorylationQRPMDGDSPSPGSSS
CCCCCCCCCCCCCCC		32.57-
403PhosphorylationPMDGDSPSPGSSSPL
CCCCCCCCCCCCCCC		45.93-
408PhosphorylationSPSPGSSSPLGAESS
CCCCCCCCCCCCCCC		26.33-
422PhosphorylationSSTSLHPSDPVEAST
CCCCCCCCCCCCCCC		43.74-
428PhosphorylationPSDPVEASTNKESRK
CCCCCCCCCCHHHHH		21.00-
433PhosphorylationEASTNKESRKSLASF
CCCCCHHHHHHHHCC		46.77-
566PhosphorylationARRRMPRSNSQENVE
CCCCCCCCCCCCCCC		34.6628450419
568PhosphorylationRRMPRSNSQENVEAS
CCCCCCCCCCCCCCC		39.8723898821
575PhosphorylationSQENVEASHPSQDGK
CCCCCCCCCCCCCHH		23.5630576142
578PhosphorylationNVEASHPSQDGKRQY
CCCCCCCCCCHHHEE		35.1622210691
724PhosphorylationLPLSTCQSIIKGLKN
CCHHHHHHHHHHHCC		28.5524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of APBA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of APBA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of APBA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
8887653
CCS_HUMANCCSphysical
11115513
CSKP_HUMANCASKphysical
9952408
STXB1_HUMANSTXBP1physical
15563604
CSKP_MOUSECaskphysical
9822620
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of APBA1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND MASSSPECTROMETRY.

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