CSKP_MOUSE - dbPTM
CSKP_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSKP_MOUSE
UniProt AC O70589
Protein Name Peripheral plasma membrane protein CASK
Gene Name Cask
Organism Mus musculus (Mouse).
Sequence Length 926
Subcellular Localization Nucleus. Cytoplasm. Cell membrane
Peripheral membrane protein.
Protein Description Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1..
Protein Sequence MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41UbiquitinationTGQQFAVKIVDVAKF
CCCEEEEEEEEHHHH		33.32-
49PhosphorylationIVDVAKFTSSPGLST
EEEHHHHCCCCCCCH		27.8220415495
50PhosphorylationVDVAKFTSSPGLSTE
EEHHHHCCCCCCCHH		37.3526643407
51PhosphorylationDVAKFTSSPGLSTED
EHHHHCCCCCCCHHH		21.6718054859
55PhosphorylationFTSSPGLSTEDLKRE
HCCCCCCCHHHHHHH		35.3526643407
56PhosphorylationTSSPGLSTEDLKREA
CCCCCCCHHHHHHHH		38.2626643407
83PhosphorylationELLETYSSDGMLYMV
HHHHHCCCCCCEEEE		27.98-
88PhosphorylationYSSDGMLYMVFEFMD
CCCCCCEEEEEEECC		5.15-
113PhosphorylationRADAGFVYSEAVASH
HCCCCCCCCHHHHHH		9.8718054859
119PhosphorylationVYSEAVASHYMRQIL
CCCHHHHHHHHHHHH		14.4618054859
121PhosphorylationSEAVASHYMRQILEA
CHHHHHHHHHHHHHH		7.4718054859
151PhosphorylationPHCVLLASKENSAPV
CCEEEEEECCCCCCE		40.24-
155PhosphorylationLLASKENSAPVKLGG
EEEECCCCCCEEECC		34.73-
182PhosphorylationVAGGRVGTPHFMAPE
CCCCCCCCCCCCCCH		15.6719060867
313PhosphorylationGAVLAAVSSHKFNSF
HHHHHHHHHCCHHHC		23.2330352176
314PhosphorylationAVLAAVSSHKFNSFY
HHHHHHHHCCHHHCC		24.8930352176
319PhosphorylationVSSHKFNSFYGDPPE
HHHCCHHHCCCCCHH		23.9929899451
348PhosphorylationLAAERAVSQVLDSLE
HHHHHHHHHHHHCHH		17.3719060867
353PhosphorylationAVSQVLDSLEEIHAL
HHHHHHHCHHHHHHH		33.2518779572
392PhosphorylationDLYDKINTKSSPQIR
HHHHHHCCCCCCCCC		35.4629514104
393UbiquitinationLYDKINTKSSPQIRN
HHHHHCCCCCCCCCC		44.44-
394PhosphorylationYDKINTKSSPQIRNP
HHHHCCCCCCCCCCC		45.2529514104
395PhosphorylationDKINTKSSPQIRNPP
HHHCCCCCCCCCCCC		23.5218054859
403PhosphorylationPQIRNPPSDAVQRAK
CCCCCCCCHHHHHHH		39.1929514104
410UbiquitinationSDAVQRAKEVLEEIS
CHHHHHHHHHHHHHC		51.01-
433PhosphorylationKELKRILTQPHFMAL
HHHHHHHHCHHHHHH		37.37-
464PhosphorylationLRVTPPPTSPYLNGD
CCCCCCCCCCCCCCC		48.3725338131
465PhosphorylationRVTPPPTSPYLNGDS
CCCCCCCCCCCCCCC		19.8125338131
554UbiquitinationQTVEQLQKMLREMRG
HHHHHHHHHHHHHCC		48.79-
562PhosphorylationMLREMRGSITFKIVP
HHHHHCCCCEEEECC		14.2125338131
564 (in isoform 3)Phosphorylation-22.1526643407
565 (in isoform 3)Phosphorylation-4.9126643407
567 (in isoform 3)Phosphorylation-4.8727742792
569 (in isoform 3)Phosphorylation-29.1725521595
570PhosphorylationITFKIVPSYRTQSSS
CEEEECCCCCCCCCC		19.1620469934
570 (in isoform 3)Phosphorylation-19.1625521595
571 (in isoform 3)Phosphorylation-16.1725521595
571PhosphorylationTFKIVPSYRTQSSSC
EEEECCCCCCCCCCC		16.1719367708
573PhosphorylationKIVPSYRTQSSSCER
EECCCCCCCCCCCCC		25.2727717184
575PhosphorylationVPSYRTQSSSCERDS
CCCCCCCCCCCCCCC		24.4929472430
576PhosphorylationPSYRTQSSSCERDSP
CCCCCCCCCCCCCCC		29.2329472430
577PhosphorylationSYRTQSSSCERDSPS
CCCCCCCCCCCCCCC		25.8329472430
577 (in isoform 3)Phosphorylation-25.8327742792
578 (in isoform 3)Phosphorylation-5.5527742792
579 (in isoform 3)Phosphorylation-62.5627742792
582PhosphorylationSSSCERDSPSTSRQS
CCCCCCCCCCCCCCC		27.2927087446
584PhosphorylationSCERDSPSTSRQSPA
CCCCCCCCCCCCCCC		42.8623684622
585PhosphorylationCERDSPSTSRQSPAN
CCCCCCCCCCCCCCC		31.1729472430
586PhosphorylationERDSPSTSRQSPANG
CCCCCCCCCCCCCCC		32.4323984901
589PhosphorylationSPSTSRQSPANGHSS
CCCCCCCCCCCCCCC		25.5225168779
595PhosphorylationQSPANGHSSTNNSVS
CCCCCCCCCCCCCCC		40.0125168779
596PhosphorylationSPANGHSSTNNSVSD
CCCCCCCCCCCCCCC		29.4925168779
597PhosphorylationPANGHSSTNNSVSDL
CCCCCCCCCCCCCCC		41.2425338131
600PhosphorylationGHSSTNNSVSDLPST
CCCCCCCCCCCCCCC		25.6828973931
602PhosphorylationSSTNNSVSDLPSTTQ
CCCCCCCCCCCCCCC		33.0025168779
606PhosphorylationNSVSDLPSTTQPKGR
CCCCCCCCCCCCCCC		51.9225168779
607PhosphorylationSVSDLPSTTQPKGRQ
CCCCCCCCCCCCCCE		27.7525168779
608PhosphorylationVSDLPSTTQPKGRQI
CCCCCCCCCCCCCEE		47.4125168779
650PhosphorylationGDIIQIISKDDHNWW
CCEEEEEECCCCCCH		31.4918054859
665UbiquitinationQGKLENSKNGTAGLI
HHHEECCCCCCCCCC		71.61-
691UbiquitinationCIAMEKTKQEQQASC
HEECCCCHHHHHHHC		64.01-
698S-palmitoylationKQEQQASCTWFGKKK
HHHHHHHCCCCCCCC		4.3528680068
708PhosphorylationFGKKKKQYKDKYLAK
CCCCCHHHHHHHHHH		29.9918054859
762UbiquitinationIKNTLITKHPDRFAY
HHCCEECCCCCCCCC		46.26-
769PhosphorylationKHPDRFAYPIPHTTR
CCCCCCCCCCCCCCC		10.0518054859
774PhosphorylationFAYPIPHTTRPPKKD
CCCCCCCCCCCCCCC		21.1018054859
775PhosphorylationAYPIPHTTRPPKKDE
CCCCCCCCCCCCCCC		37.8418054859
825UbiquitinationTKLETIRKIHEQGLI
CHHHHHHHHHHCCCE		44.56-
871PhosphorylationPGLNEDESLQRLQKE
CCCCCHHHHHHHHHH		41.9730352176
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
51SPhosphorylationKinaseCDK5Q00535
PSP
51SPhosphorylationKinaseCDK5P49615
PSP
395SPhosphorylationKinaseCDK5Q00535
PSP
395SPhosphorylationKinaseCDK5P49615
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSKP_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSKP_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LIPA2_MOUSEPpfia2physical
16186258
APBA1_HUMANAPBA1physical
9822620
LIN7C_MOUSELin7cphysical
9822620
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSKP_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-571, AND MASSSPECTROMETRY.

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