NXPE4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NXPE4_HUMAN
• UniProt AC: Q6UWF7
• Protein Name: NXPE family member 4
• Gene Name: NXPE4
• Organism: Homo sapiens (Human).
• Sequence Length: 544
• Subcellular Localization: Secreted .
• Protein Sequence: MKISMINYKSLLALLFILASWIIFTVFQNSTKVWSALNLSISLHYWNNSTKSLFPKTPLISLKPLTETELRIKEIIEKLDQQIPPRPFTHVNTTTSATHSTATILNPRDTYCRGDQLHILLEVRDHLGRRKQYGGDFLRARMSSPALMAGASGKVTDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGVSALWSARNQGYDRVIFTGQFVNGTSQVHSECGLILNTNAELCQYLDNRDQEGFYCVRPQHMPCAALTHMYSKNKKVSYLSKQEKSLFERSNVGVEIMEKFNTISVSKCNKETVAMKEKCKFGMTSTIPSGHVWRNTWNPVSCSLATVKMKECLRGKLIYLMGDSTIRQWMEYFKASINTLKSVDLHESGKLQHQLAVDLDRNINIQWQKYCYPLIGSMTYSVKEMEYLTRAIDRTGGEKNTVIVISLGQHFRPFPIDVFIRRALNVHKAIQHLLLRSPDTMVIIKTENIREMYNDAERFSDFHGYIQYLIIKDIFQDLSVSIIDAWDITIAYGTNNVHPPQHVVGNQINILLNYIC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MKISMINYKSL ----CCCCCCCHHHH		24719451
29	N-linked_Glycosylation	IIFTVFQNSTKVWSA HHHHHHCCCHHHHHH		UniProtKB CARBOHYD
38	N-linked_Glycosylation	TKVWSALNLSISLHY HHHHHHHEEEEEEEE		UniProtKB CARBOHYD
47	N-linked_Glycosylation	SISLHYWNNSTKSLF EEEEEECCCCCCCCC		UniProtKB CARBOHYD
48	N-linked_Glycosylation	ISLHYWNNSTKSLFP EEEEECCCCCCCCCC		UniProtKB CARBOHYD
61	Phosphorylation	FPKTPLISLKPLTET CCCCCCEECCCCCHH		24719451
66	Phosphorylation	LISLKPLTETELRIK CEECCCCCHHHHHHH		-
92	N-linked_Glycosylation	PRPFTHVNTTTSATH CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
94	Acetylation	PFTHVNTTTSATHST CCCCCCCCCCCCCCE		19413330
143	Phosphorylation	DFLRARMSSPALMAG CHHHHHCCCCCHHCC		-
152	Phosphorylation	PALMAGASGKVTDFN CCHHCCCCCEEEECC		-
160	N-linked_Glycosylation	GKVTDFNNGTYLVSF CEEEECCCCEEEEEE		UniProtKB CARBOHYD
205	Phosphorylation	GYDRVIFTGQFVNGT CCCEEEEEEECCCCC		-
210	N-linked_Glycosylation	IFTGQFVNGTSQVHS EEEEECCCCCCCCCC		UniProtKB CARBOHYD
259	Phosphorylation	AALTHMYSKNKKVSY HHHHHHHCCCCCHHH		24719451
292	Phosphorylation	MEKFNTISVSKCNKE HHHHCEEEEECCCHH		24719451
304	Acetylation	NKETVAMKEKCKFGM CHHHHHCCCCCCCCC		12433651
347	Phosphorylation	CLRGKLIYLMGDSTI HHCCCEEECCCCHHH		-
352	Phosphorylation	LIYLMGDSTIRQWME EEECCCCHHHHHHHH		22210691
378	Acetylation	VDLHESGKLQHQLAV EEHHCCCCCEEEEEE		19413330
398	Phosphorylation	INIQWQKYCYPLIGS CEEEEHHHHHHHHCC		23090842
400	Phosphorylation	IQWQKYCYPLIGSMT EEEHHHHHHHHCCCE		23090842
405	Phosphorylation	YCYPLIGSMTYSVKE HHHHHHCCCEEEHHH		27732954
407	Phosphorylation	YPLIGSMTYSVKEME HHHHCCCEEEHHHHH		27732954
408	Phosphorylation	PLIGSMTYSVKEMEY HHHCCCEEEHHHHHH		23090842
409	Phosphorylation	LIGSMTYSVKEMEYL HHCCCEEEHHHHHHH		27732954
415	Phosphorylation	YSVKEMEYLTRAIDR EEHHHHHHHHHHHHH		22964224
417	Phosphorylation	VKEMEYLTRAIDRTG HHHHHHHHHHHHHCC		23090842

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NXPE4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NXPE4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NXPE4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NXPE4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.