dbPTM

CD046_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CD046_HUMAN
UniProt AC	Q504U0
Protein Name	Renal cancer differentiation gene 1 protein {ECO:0000303\|PubMed:25059753}
Gene Name	C4orf46
Organism	Homo sapiens (Human).
Sequence Length	113
Subcellular Localization	Cytoplasm .
Protein Description
Protein Sequence	MADPEELQVSSPPPPPPSSPSSSDASAASSPGGPVSLGWPVPSRSSGPTVDQLEEVELQIGDAAFSLTKLLEATSAVSAQVEELAFKCTENARFLKTWRDLLKEGYDSLKPDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DPEELQVSSPPPPPP CHHHCCCCCCCCCCC	24.94	28348404
11	Phosphorylation	PEELQVSSPPPPPPS HHHCCCCCCCCCCCC	42.44	28348404
18	Phosphorylation	SPPPPPPSSPSSSDA CCCCCCCCCCCCCCC	61.73	28348404
19	Phosphorylation	PPPPPPSSPSSSDAS CCCCCCCCCCCCCCH	34.28	28348404
21	Phosphorylation	PPPPSSPSSSDASAA CCCCCCCCCCCCHHH	44.41	28348404
22	Phosphorylation	PPPSSPSSSDASAAS CCCCCCCCCCCHHHC	35.30	28348404
23	Phosphorylation	PPSSPSSSDASAASS CCCCCCCCCCHHHCC	41.35	28348404
26	Phosphorylation	SPSSSDASAASSPGG CCCCCCCHHHCCCCC	29.38	26074081
29	Phosphorylation	SSDASAASSPGGPVS CCCCHHHCCCCCCCC	36.46	26074081
30	Phosphorylation	SDASAASSPGGPVSL CCCHHHCCCCCCCCC	23.88	26074081
36	Phosphorylation	SSPGGPVSLGWPVPS CCCCCCCCCCCCCCC	25.05	26074081
87	Ubiquitination	QVEELAFKCTENARF HHHHHHHHHHHHHHH	34.34	29967540
96	Ubiquitination	TENARFLKTWRDLLK HHHHHHHHHHHHHHH	43.24	-
103	Ubiquitination	KTWRDLLKEGYDSLK HHHHHHHHHCHHHCC	57.29	-
110	Ubiquitination	KEGYDSLKPDD---- HHCHHHCCCCC----	50.80	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CD046_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CD046_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CD046_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CD046_HUMAN

Related Literatures of Post-Translational Modification