LRC34_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC34_HUMAN
• UniProt AC: Q8IZ02
• Protein Name: Leucine-rich repeat-containing protein 34
• Gene Name: LRRC34
• Organism: Homo sapiens (Human).
• Sequence Length: 464
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Cytoplasm . As stem cells differentiate, translocates from the nucleolus to the nucleus and then to the cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus.
• Protein Description: Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro..
• Protein Sequence: MAAQPPRPVGERSMGSSREAARAPARSPAWASTQASTPGAALAVQRESPESGLQKHYSNLCMEKSQKINPFILHILQEVDEEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTQNQAIKAINLNRPILYSEQEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTYGESYDHSSNAGFALVPVGQQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	RPVGERSMGSSREAA CCCCCCCCCCCHHHH	22.52	27966365
19	Phosphorylation	RSMGSSREAARAPAR CCCCCCHHHHHCCCC	15.45	27174698
20	Phosphorylation	SMGSSREAARAPARS CCCCCHHHHHCCCCC	22.02	27174698
23	Phosphorylation	SSREAARAPARSPAW CCHHHHHCCCCCCHH	25.89	27174698
24	Phosphorylation	SREAARAPARSPAWA CHHHHHCCCCCCHHH	28.85	27174698
35	Phosphorylation	PAWASTQASTPGAAL CHHHCCCCCCCCCEE	35.84	27174698
38	Phosphorylation	ASTQASTPGAALAVQ HCCCCCCCCCEEEEC	48.46	27174698
44	Phosphorylation	TPGAALAVQRESPES CCCCEEEECCCCCCC	13.29	27174698
45	Phosphorylation	PGAALAVQRESPESG CCCEEEECCCCCCCH	24.05	27174698
51	Ubiquitination	VQRESPESGLQKHYS ECCCCCCCHHHHHHH	31.16	-
57	Phosphorylation	ESGLQKHYSNLCMEK CCHHHHHHHHHHHHH	22.56	27642862
104	Ubiquitination	GNNRLVPVERVTGED CCCCEEEEEECCCCC	48.92	-
169	Ubiquitination	DIGPEGGELIAKVLH CCCCCCHHHHHHHHH	41.44	-
236	Phosphorylation	TVLTQNQAIKAINLN HHHCCCHHHHHHCCC	32.07	24719451
246	Phosphorylation	AINLNRPILYSEQEE HHCCCCCCCCCCCCC	12.93	24719451
262	Phosphorylation	TVHVGRMLKENHCLV CHHHHHHHHHCCCEE	18.61	-
268	Phosphorylation	MLKENHCLVALHMCK HHHHCCCEEEEHHCH	6.31	-
281	Phosphorylation	CKHDIKNSGIQQLCD CHHHHHCCCHHHHHH	4.67	24719451
291	Phosphorylation	QQLCDALYLNSSLRY HHHHHHHHHCCCCCE	41.10	24719451
312	Phosphorylation	KITHDGMVYLADVLK EEECCCEEHHHHHHH	25.90	22210691
315	Phosphorylation	HDGMVYLADVLKSNT CCCEEHHHHHHHCCC	23.23	22210691
389	Ubiquitination	SHIYIWGNKFDEATC EEEEEECCCCCCCHH	38.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC34_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC34_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC34_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LRC34_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.