DYH9_HUMAN - dbPTM
DYH9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DYH9_HUMAN
UniProt AC Q9NYC9
Protein Name Dynein heavy chain 9, axonemal
Gene Name DNAH9
Organism Homo sapiens (Human).
Sequence Length 4486
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme.
Protein Description Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP..
Protein Sequence MRLAEERAALAAENADGEPGADRRLRLLGTYVAMSLRPAAGAWERCAGSAEAEQLLQAFLGRDAAEGPRPLLVVRPGPRGLAIRPGLEVGPESGLAGAKALFFLRTGPEPPGPDSFRGAVVCGDLPAAPLEHLAALFSEVVLPVLANEKNRLNWPHMICEDVRRHAHSLQCDLSVILEQVKGKTLLPLPAGSEKMEFADSKSETVLDSIDKSVIYAIESAVIKWSYQVQVVLKRESSQPLLQGENPTPKVELEFWKSRYEDLKYIYNQLRTITVRGMAKLLDKLQSSYFPAFKAMYRDVVAALAEAQDIHVHLIPLQRHLEALENAEFPEVKPQLRPLLHVVCLIWATCKSYRSPGRLTVLLQEICNLLIQQASNYLSPEDLLRSEVEESQRKLQVVSDTLSFFKQEFQDRRENLHTYFKENQEVKEWDFQSSLVFVRLDGFLGQLHVVEGLLKTALDFHKLGKVEFSGVRGNALSQQVQQMHEEFQEMYRLLSGSSSDCLYLQSTDFENDVSEFNQKVEDLDRRLGTIFIQAFDDAPGLEHAFKLLDIAGNLLERPLVARDTSDKYLVLIQMFNKDLDAVRMIYSQHVQEEAELGFSPVHKNMPTVAGGLRWAQELRQRIQGPFSNFGRITHPCMESAEGKRMQQKYEDMLSLLEKYETRLYEDWCRTVSEKSQYNLSQPLLKRDPETKEITINFNPQLISVLKEMSYLEPREMKHMPETAAAMFSSRDFYRQLVANLELMANWYNKVMKTLLEVEFPLVEEELQNIDLRLRAAEETLNWKTEGICDYVTEITSSIHDLEQRIQKTKDNVEEIQNIMKTWVTPIFKTKDGKRESLLSLDDRHDRMEKYYNLIKESGLKIHALVQENLGLFSADPTSNIWKTYVNSIDNLLLNGFFLAIECSLKYLLENTECKAGLTPIFEAQLSLAIPELVFYPSLESGVKGGFCDIVEGLITSIFRIPSLVPRLSPQNGSPHYQVDLDGIPDLANMRRTLMERVQRMMGLCCGYQSTFSQYSYLYVEDRKEVLGQFLLYGHILTPEEIEDHVEDGIPENPPLLSQFKVQIDSYETLYEEVCRLEPIKVFDGWMKIDIRPFKASLLNIIKRWSLLFKQHLVDHVTHSLANLDAFIKKSESGLLKKVEKGDFQGLVEIMGHLMAVKERQSNTDEMFEPLKQTIELLKTYEQELPETVFKQLEELPEKWNNIKKVAITVKQQVAPLQANEVTLLRQRCTAFDAEQQQFWEQFHKEAPFRFDSIHPHQMLDARHIEIQQMESTMASISESASLFEVNVPDYKQLRQCRKEVCQLKELWDTIGMVTSSIHAWETTPWRNINVEAMELECKQFARHIRNLDKEVRAWDAFTGLESTVWNTLSSLRAVAELQNPAIRERHWRQLMQATGVSFTMDQDTTLAHLLQLQLHHYEDEVRGIVDKAAKEMGMEKTLKELQTTWAGMEFQYEPHPRTNVPLLCSDEDLIEVLEDNQVQLQNLVMSKYVAFFLEEVSGWQKKLSTVDAVISIWFEVQRTWTHLESIFTGSEDIRAQLPQDSKRFEGIDIDFKELAYDAQKIPNVVQTTNKPGLYEKLEDIQGRLCLCEKALAEYLDTKRLAFPRFYFLSSSDLLDILSNGTAPQQVQRHLSKLFDNMAKMRFQLDASGEPTKTSLGMYSKEEEYVAFSEPCDCSGQVEIWLNHVLGHMKATVRHEMTEGVTAYEEKPREQWLFDHPAQVALTCTQIWWTTEVGMAFARLEEGYESAMKDYYKKQVAQLKTLITMLIGQLSKGDRQKIMTICTIDVHARDVVAKMIAQKVDNAQAFLWLSQLRHRWDDEVKHCFANICDAQFLYSYEYLGNTPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGILVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVVAVQVKSIQDAIRDKKQWFSFLGEEISLNPSVGIFITMNPGYAGRTELPENLKSLFRPCAMVVPDFELICEIMLVAEGFIEAQSLARKFITLYQLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPDRPEDQVLMRSLRDFNIPKIVTDDMPIFMGLIGDLFPALDVPRRRDPNFEALVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHSVFVVGGAGTGKSQVLRSLHKTYQIMKRRPVWTDLNPKAVTNDELFGIINPATGEWKDGLFSSIMRELANITHDGPKWILLDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNPTMKLLFEISHLRTATPATVSRAGILYINPADLGWNPPVSSWIEKREIQTERANLTILFDKYLPTCLDTLRTRFKKIIPIPEQSMVQMVCHLLECLLTTEDIPADCPKEIYEHYFVFAAIWAFGGAMVQDQLVDYRAEFSKWWLTEFKTVKFPSQGTIFDYYIDPETKKFEPWSKLVPQFEFDPEMPLQACLVHTSETIRVCYFMERLMARQRPVMLVGTAGTGKSVLVGAKLASLDPEAYLVKNVPFNYYTTSAMLQAVLEKPLEKKAGRNYGPPGNKKLIYFIDDMNMPEVDAYGTVQPHTIIRQHLDYGHWYDRSKLSLKEITNVQYVSCMNPTAGSFTINPRLQRHFSVFVLSFPGADALSSIYSIILTQHLKLGNFPASLQKSIPPLIDLALAFHQKIATTFLPTGIKFHYIFNLRDFANIFQGILFSSVECVKSTWDLIRLYLHESNRVYRDKMVEEKDFDLFDKIQTEVLKKTFDDIEDPVEQTQSPNLYCHFANGIGEPKYMPVQSWELLTQTLVEALENHNEVNTVMDLVLFEDAMRHVCHINRILESPRGNALLVGVGGSGKQSLTRLAAFISSMDVFQITLRKGYQIQDFKMDLASLCLKAGVKNLNTVFLMTDAQVADERFLVLINDLLASGEIPDLYSDDEVENIISNVRNEVKSQGLVDNRENCWKFFIDRIRRQLKVTLCFSPVGNKLRVRSRKFPAIVNCTAIHWFHEWPQQALESVSLRFLQNTEGIEPTVKQSISKFMAFVHTSVNQTSQSYLSNEQRYNYTTPKSFLEFIRLYQSLLHRHRKELKCKTERLENGLLKLHSTSAQVDDLKAKLAAQEVELKQKNEDADKLIQVVGVETDKVSREKAMADEEEQKVAVIMLEVKQKQKDCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLMAPRGRVPKDRSWKAAKVTMAKVDGFLDSLINFNKENIHENCLKAIRPYLQDPEFNPEFVATKSYAAAGLCSWVINIVRFYEVFCDVEPKRQALNKATADLTAAQEKLAAIKAKIAHLNENLAKLTARFEKATADKLKCQQEAEVTAVTISLANRLVGGLASENVRWADAVQNFKQQERTLCGDILLITAFISYLGFFTKKYRQSLLDRTWRPYLSQLKTPIPVTPALDPLRMLMDDADVAAWQNEGLPADRMSVENATILINCERWPLMVDPQLQGIKWIKNKYGEDLRVTQIGQKGYLQIIEQALEAGAVVLIENLEESIDPVLGPLLGREVIKKGRFIKIGDKECEYNPKFRLILHTKLANPHYQPELQAQATLINFTVTRDGLEDQLLAAVVSMERPDLEQLKSDLTKQQNGFKITLKTLEDSLLSRLSSASGNFLGETVLVENLEITKQTAAEVEKKVQEAKVTEVKINEAREHYRPAAARASLLYFIMNDLSKIHPMYQFSLKAFSIVFQKAVERAAPDESLRERVANLIDSITFSVYQYTIRGLFECDKLTYLAQLTFQILLMNREVNAVELDFLLRSPVQTGTASPVEFLSHQAWGAVKVLSSMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQEWKNKTALQRLCMLRAMRPDRMTYALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMFFILSPGVDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLSTLEKKLEEHSENSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPTGMHANLHKALDNFTQDTLEMCSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANAKVPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEMLEGELSLAPGFPLPGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVLELQPRDSQARDGAGATREEKVKALLEEILERVTDEFNIPELMAKVEERTPYIVVAFQECGRMNILTREIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRIKELEAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDMTKKNREEFRSPPREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQDCRSVYSCPVYKTSQRGPTYVWTFNLKTKENPSKWVLAGVALLLQI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30PhosphorylationRRLRLLGTYVAMSLR
HHHHHHHHHHHHHCC		18.1320068231
31PhosphorylationRLRLLGTYVAMSLRP
HHHHHHHHHHHHCCC		5.6122210691
35PhosphorylationLGTYVAMSLRPAAGA
HHHHHHHHCCCCCCC		16.1022210691
192PhosphorylationLLPLPAGSEKMEFAD
EEECCCCCCCCCCCC		35.83-
225PhosphorylationESAVIKWSYQVQVVL
HHHHHHEEEEEEEEE		10.73-
259PhosphorylationLEFWKSRYEDLKYIY
HHHHHHHHHHHHHHH		22.3823403867
351PhosphorylationLIWATCKSYRSPGRL
HHHHHHHHCCCCCHH		28.1127174698
354PhosphorylationATCKSYRSPGRLTVL
HHHHHCCCCCHHHHH		24.3927174698
567PhosphorylationARDTSDKYLVLIQMF
ECCCCCCEEEEHHHH		13.6620068231
648PhosphorylationGKRMQQKYEDMLSLL
CHHHHHHHHHHHHHH		16.9023663014
653PhosphorylationQKYEDMLSLLEKYET
HHHHHHHHHHHHHHH		25.0324719451
702PhosphorylationNFNPQLISVLKEMSY
ECCHHHHHHHHHHCC		29.95-
708PhosphorylationISVLKEMSYLEPREM
HHHHHHHCCCCHHHH		27.88-
807PhosphorylationLEQRIQKTKDNVEEI
HHHHHHHCCCCHHHH		27.5330622161
835PhosphorylationTKDGKRESLLSLDDR
CCCCCCCCCCCCCCC		38.3529052541
838PhosphorylationGKRESLLSLDDRHDR
CCCCCCCCCCCCHHH		34.7429052541
995DimethylationMRRTLMERVQRMMGL
HHHHHHHHHHHHHHH		18.86-
1128AcetylationNLDAFIKKSESGLLK
CHHHHHHHCCCCCCH		55.427338461
1135AcetylationKSESGLLKKVEKGDF
HCCCCCCHHHHCCCH		60.877338469
1136AcetylationSESGLLKKVEKGDFQ
CCCCCCHHHHCCCHH		56.447338477
1178PhosphorylationQTIELLKTYEQELPE
HHHHHHHHHHHHCCH		32.0629978859
1186PhosphorylationYEQELPETVFKQLEE
HHHHCCHHHHHHHHH		29.3329978859
1368PhosphorylationSTVWNTLSSLRAVAE
HHHHHHHHHHHHHHH		25.8630301811
1369PhosphorylationTVWNTLSSLRAVAEL
HHHHHHHHHHHHHHH		25.6125954137
1396PhosphorylationLMQATGVSFTMDQDT
HHHHHCCCEECCCHH		19.1518452278
1436PhosphorylationKEMGMEKTLKELQTT
HHHCCHHHHHHHHHH		29.7422210691
1658PhosphorylationKTSLGMYSKEEEYVA
CCEECCCCCCCEEEE		25.3824719451
1696O-linked_GlycosylationATVRHEMTEGVTAYE
HHHHHHCCCCCCCCC		26.9730379171
1742PhosphorylationFARLEEGYESAMKDY
HHHHHHHHHHHHHHH		15.2529978859
1744PhosphorylationRLEEGYESAMKDYYK
HHHHHHHHHHHHHHH		25.7729978859
1749PhosphorylationYESAMKDYYKKQVAQ
HHHHHHHHHHHHHHH		16.2129978859
1750PhosphorylationESAMKDYYKKQVAQL
HHHHHHHHHHHHHHH		23.1129978859
1759PhosphorylationKQVAQLKTLITMLIG
HHHHHHHHHHHHHHH		31.80-
1762PhosphorylationAQLKTLITMLIGQLS
HHHHHHHHHHHHHCC		14.72-
1769PhosphorylationTMLIGQLSKGDRQKI
HHHHHHCCCCCHHHC		27.06-
1877PhosphorylationGPAGTGKTETTKDLG
CCCCCCCCCCHHHHH		39.6519664994
2025PhosphorylationSLARKFITLYQLCKE
HHHHHHHHHHHHHHH		23.6525101063
2027PhosphorylationARKFITLYQLCKELL
HHHHHHHHHHHHHHH		7.2625101063
2056PhosphorylationSVLVVAGSLKRGDPD
HHHHHCCCCCCCCCC		22.4524719451
2146PhosphorylationELLAVRHSVFVVGGA
HHHCCCCEEEEECCC		13.4920068231
2155PhosphorylationFVVGGAGTGKSQVLR
EEECCCCCCHHHHHH		40.6820068231
2158PhosphorylationGGAGTGKSQVLRSLH
CCCCCCHHHHHHHHH		27.1920068231
2168PhosphorylationLRSLHKTYQIMKRRP
HHHHHHHHHHHHCCC		10.8024260401
2273PhosphorylationFEISHLRTATPATVS
HHHHHHCCCCCCEEC		41.0420860994
2278PhosphorylationLRTATPATVSRAGIL
HCCCCCCEECCCEEE		21.8820860994
2494PhosphorylationLVGAKLASLDPEAYL
HHCCEECCCCHHHHE		43.6827251275
2591PhosphorylationITNVQYVSCMNPTAG
CCCCEEEEECCCCCC		11.60-
2711PhosphorylationIRLYLHESNRVYRDK
HHHHHHHCCCCCHHH		21.1326270265
2715PhosphorylationLHESNRVYRDKMVEE
HHHCCCCCHHHCCHH		15.1726270265
2733PhosphorylationDLFDKIQTEVLKKTF
CHHHHHHHHHHHHHC		31.38-
2833PhosphorylationVGGSGKQSLTRLAAF
CCCCCHHHHHHHHHH		34.8818452278
2991PhosphorylationWPQQALESVSLRFLQ
CHHHHHHHCCHHHHH		20.1824719451
2993PhosphorylationQQALESVSLRFLQNT
HHHHHHCCHHHHHCC		24.0924719451
3053PhosphorylationEFIRLYQSLLHRHRK
HHHHHHHHHHHHHHH		21.2424247654
3080PhosphorylationLLKLHSTSAQVDDLK
HHHHHCCCCCHHHHH		21.5127134283
3307UbiquitinationQEKLAAIKAKIAHLN
HHHHHHHHHHHHHHH		38.61-
33072-HydroxyisobutyrylationQEKLAAIKAKIAHLN
HHHHHHHHHHHHHHH		38.61-
3411PhosphorylationRTWRPYLSQLKTPIP
HCCHHHHHCCCCCCC		27.8524719451
3415PhosphorylationPYLSQLKTPIPVTPA
HHHHCCCCCCCCCCC		34.7321406692
3420PhosphorylationLKTPIPVTPALDPLR
CCCCCCCCCCCCHHH		9.4821406692
3615PhosphorylationQQNGFKITLKTLEDS
HCCCEEEEEHHHHHH		23.8524719451
3622PhosphorylationTLKTLEDSLLSRLSS
EEHHHHHHHHHHHHC		23.1024719451
3625PhosphorylationTLEDSLLSRLSSASG
HHHHHHHHHHHCCCC		36.1524719451
3683PhosphorylationRPAAARASLLYFIMN
CHHHHHHHHHHHHHH		17.2226270265
3686PhosphorylationAARASLLYFIMNDLS
HHHHHHHHHHHHCHH		9.0626270265
3742PhosphorylationTFSVYQYTIRGLFEC
HHCCHHHHHHCHHHC		6.6724719451
3753PhosphorylationLFECDKLTYLAQLTF
HHHCCHHHHHHHHHH		23.4124043423
3754PhosphorylationFECDKLTYLAQLTFQ
HHCCHHHHHHHHHHH		15.5224043423
3863PhosphorylationAMRPDRMTYALRDFV
HHCCCHHHHHHHHHH		13.4126552605
3864PhosphorylationMRPDRMTYALRDFVE
HCCCHHHHHHHHHHH		8.3626552605
4102PhosphorylationEANAKVPYDDLRYLF
HHCCCCCHHHHHHHH		25.6928060719
4305PhosphorylationYFDMVPESWARRAYP
HCCCCCHHHHHHHCC		21.7026074081
4311PhosphorylationESWARRAYPSTAGLA
HHHHHHHCCCCHHHH		8.9026074081
4313PhosphorylationWARRAYPSTAGLAAW
HHHHHCCCCHHHHHH		20.4326074081
4314PhosphorylationARRAYPSTAGLAAWF
HHHHCCCCHHHHHHC		21.9026074081
4390PhosphorylationKNREEFRSPPREGAY
HCHHHHCCCCCCCCC		44.5717081983
4446PhosphorylationKQDCRSVYSCPVYKT
CCCCCCCCCCCEEEC		13.0528348404
4447PhosphorylationQDCRSVYSCPVYKTS
CCCCCCCCCCEEECC		15.1328348404
4451PhosphorylationSVYSCPVYKTSQRGP
CCCCCCEEECCCCCC		8.1628348404
4453PhosphorylationYSCPVYKTSQRGPTY
CCCCEEECCCCCCEE		16.6528348404
4454PhosphorylationSCPVYKTSQRGPTYV
CCCEEECCCCCCEEE		17.4628348404
4473PhosphorylationLKTKENPSKWVLAGV
CCCCCCHHHHHHHHH		51.21-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DYH9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DYH9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DYH9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAM_HUMANFAM103A1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DYH9_HUMAN

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Related Literatures of Post-Translational Modification

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