dbPTM

FA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FA5_HUMAN
UniProt AC	P12259
Protein Name	Coagulation factor V
Gene Name	F5
Organism	Homo sapiens (Human).
Sequence Length	2224
Subcellular Localization	Secreted.
Protein Description	Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin..
Protein Sequence	MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPSMDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDIY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	SYRPEPTNSSLNLSV CCCCCCCCCCCEEEE	40.07	UniProtKB CARBOHYD
55	N-linked_Glycosylation	EPTNSSLNLSVTSFK CCCCCCCEEEECEEE	32.02	UniProtKB CARBOHYD
123	Phosphorylation	GIRYSKLSEGASYLD CCCCEECCCCCCCCC	37.41	22964224
127	Phosphorylation	SKLSEGASYLDHTFP EECCCCCCCCCCCCC	36.77	22964224
128	Phosphorylation	KLSEGASYLDHTFPA ECCCCCCCCCCCCCH	18.67	22964224
132	O-linked_Glycosylation	GASYLDHTFPAEKMD CCCCCCCCCCHHHCC	30.86	OGP
132	Phosphorylation	GASYLDHTFPAEKMD CCCCCCCCCCHHHCC	30.86	22964224
239	N-linked_Glycosylation	YTVNGYVNGTMPDIT EEECCEECCCCCCEE	31.56	UniProtKB CARBOHYD
284	Phosphorylation	EQNHHKVSAITLVSA ECCCCCEEEEEEEEE	20.82	-
297	N-linked_Glycosylation	SATSTTANMTVGPEG EECCCCCCCCCCCCC	25.27	16335952
323	Phosphorylation	LQAGMQAYIDIKNCP HHHHHHEEEECCCCC	5.13	-
382	N-linked_Glycosylation	YRSQHLDNFSNQIGK HHHHHHHHHHHHHHH	48.91	UniProtKB CARBOHYD
391	Phosphorylation	SNQIGKHYKKVMYTQ HHHHHHHHHHCEEEE	18.91	26074081
396	Phosphorylation	KHYKKVMYTQYEDES HHHHHCEEEEECCCC	8.15	26074081
397	Phosphorylation	HYKKVMYTQYEDESF HHHHCEEEEECCCCC	13.43	26074081
399	Phosphorylation	KKVMYTQYEDESFTK HHCEEEEECCCCCCC	19.97	26074081
403	Phosphorylation	YTQYEDESFTKHTVN EEEECCCCCCCCCCC	51.00	26074081
405	Phosphorylation	QYEDESFTKHTVNPN EECCCCCCCCCCCCC	31.06	26074081
460	N-linked_Glycosylation	SPYEDEVNSSFTSGR CCCCCCCCCCCCCCC	29.86	16335952
468	N-linked_Glycosylation	SSFTSGRNNTMIRAV CCCCCCCCCCEEEEE	52.42	UniProtKB CARBOHYD
470	Phosphorylation	FTSGRNNTMIRAVQP CCCCCCCCEEEEECC	19.95	22210691
481	Phosphorylation	AVQPGETYTYKWNIL EECCCCCEEEEEEEE	12.08	22210691
483	Phosphorylation	QPGETYTYKWNILEF CCCCCEEEEEEEEEC	12.00	22210691
517	Phosphorylation	DIMRDIASGLIGLLL HHHHHHHHHHHHHHH	34.17	-
528	Phosphorylation	GLLLICKSRSLDRRG HHHHHHHCCCCCCCC	23.77	26699800
530	Phosphorylation	LLICKSRSLDRRGIQ HHHHHCCCCCCCCHH	41.53	26699800
554	N-linked_Glycosylation	VFAVFDENKSWYLED EEEEECCCCCEEECC	45.57	UniProtKB CARBOHYD
640	Phosphorylation	YGKRHEDTLTLFPMR CCCCCCCEEEEEECC	20.75	19060867
642	Phosphorylation	KRHEDTLTLFPMRGE CCCCCEEEEEECCCC	28.57	19690332
654	Phosphorylation	RGESVTVTMDNVGTW CCCEEEEEECCCCEE	14.94	22210691
664	Phosphorylation	NVGTWMLTSMNSSPR CCCEEEEEECCCCCC	15.15	22210691
692	Phosphorylation	IPDDDEDSYEIFEPP CCCCCCCCCCCCCCC	23.71	26657352
693	Phosphorylation	PDDDEDSYEIFEPPE CCCCCCCCCCCCCCC	25.93	19824718
693	Sulfation	PDDDEDSYEIFEPPE CCCCCCCCCCCCCCC	25.93	-
693	Sulfation	PDDDEDSYEIFEPPE CCCCCCCCCCCCCCC	25.93	-
706	Phosphorylation	PESTVMATRKMHDRL CCCCEEHEHHCHHCC	16.84	-
720	Phosphorylation	LEPEDEESDADYDYQ CCCCCCCCCCCCCHH	35.73	28060719
724	Phosphorylation	DEESDADYDYQNRLA CCCCCCCCCHHHHHH	20.47	28060719
724	Sulfation	DEESDADYDYQNRLA CCCCCCCCCHHHHHH	20.47	-
724	Sulfation	DEESDADYDYQNRLA CCCCCCCCCHHHHHH	20.47	-
726	Phosphorylation	ESDADYDYQNRLAAA CCCCCCCHHHHHHHH	11.06	28060719
726	Sulfation	ESDADYDYQNRLAAA CCCCCCCHHHHHHHH	11.06	-
726	Sulfation	ESDADYDYQNRLAAA CCCCCCCHHHHHHHH	11.06	-
741	N-linked_Glycosylation	LGIRSFRNSSLNQEE HCCHHHCCCCCCCCH	33.66	UniProtKB CARBOHYD
752	N-linked_Glycosylation	NQEEEEFNLTALALE CCCHHHHHHHHHHHH	39.50	UniProtKB CARBOHYD
760	N-linked_Glycosylation	LTALALENGTEFVSS HHHHHHHCCCEEECC	64.63	UniProtKB CARBOHYD
776	N-linked_Glycosylation	TDIIVGSNYSSPSNI CEEEECCCCCCCCCC	34.47	16263699
782	N-linked_Glycosylation	SNYSSPSNISKFTVN CCCCCCCCCCCCEEC	46.03	16263699
787	O-linked_Glycosylation	PSNISKFTVNNLAEP CCCCCCCEECCCCCC	26.51	OGP
787	Phosphorylation	PSNISKFTVNNLAEP CCCCCCCEECCCCCC	26.51	24505115
804	O-linked_Glycosylation	APSHQQATTAGSPLR CCCCCCCCCCCCHHH	16.91	55824799
805	O-linked_Glycosylation	PSHQQATTAGSPLRH CCCCCCCCCCCHHHH	31.85	55824805
821	N-linked_Glycosylation	IGKNSVLNSSTAEHS HCCCCCCCCCCCCCC	31.58	16335952
832	O-linked_Glycosylation	AEHSSPYSEDPIEDP CCCCCCCCCCCCCCC	38.62	OGP
851	O-linked_Glycosylation	VTGIRLLSLGAGEFK CCEEEEEEECCCCCC	29.37	OGP
851	Phosphorylation	VTGIRLLSLGAGEFK CCEEEEEEECCCCCC	29.37	28060719
859	Phosphorylation	LGAGEFKSQEHAKHK ECCCCCCCHHHHHHC	46.23	27130503
864	Acetylation	FKSQEHAKHKGPKVE CCCHHHHHHCCCCCC	47.99	30588651
866	Acetylation	SQEHAKHKGPKVERD CHHHHHHCCCCCCHH	75.98	30588655
895	Phosphorylation	HKVGRHLSQDTGSPS HHHHHHHCCCCCCCC	21.64	27251275
898	Phosphorylation	GRHLSQDTGSPSGMR HHHHCCCCCCCCCCC	31.74	22210691
900	O-linked_Glycosylation	HLSQDTGSPSGMRPW HHCCCCCCCCCCCCH	20.27	OGP
900	Phosphorylation	HLSQDTGSPSGMRPW HHCCCCCCCCCCCCH	20.27	22210691
912	Phosphorylation	RPWEDLPSQDTGSPS CCHHHCCCCCCCCCC	48.24	24505115
915	Phosphorylation	EDLPSQDTGSPSRMR HHCCCCCCCCCCCCC	31.74	22210691
917	Phosphorylation	LPSQDTGSPSRMRPW CCCCCCCCCCCCCCC	23.07	22210691
919	Phosphorylation	SQDTGSPSRMRPWKD CCCCCCCCCCCCCCC	40.17	22210691
929	Phosphorylation	RPWKDPPSDLLLLKQ CCCCCCCHHEEEEEC	46.40	28060719
937	Phosphorylation	DLLLLKQSNSSKILV HEEEEECCCCCCEEE	36.77	-
938	N-linked_Glycosylation	LLLLKQSNSSKILVG EEEEECCCCCCEEEE	48.05	UniProtKB CARBOHYD
951	O-linked_Glycosylation	VGRWHLASEKGSYEI EEEEEECCCCCCEEE	46.32	OGP
951	Phosphorylation	VGRWHLASEKGSYEI EEEEEECCCCCCEEE	46.32	27130503
955	Phosphorylation	HLASEKGSYEIIQDT EECCCCCCEEEEECC	30.57	27130503
977	N-linked_Glycosylation	NWLISPQNASRAWGE CEEECHHHHHHHCCC	43.18	16335952
985	O-linked_Glycosylation	ASRAWGESTPLANKP HHHHCCCCCCCCCCC	31.24	OGP
986	O-linked_Glycosylation	SRAWGESTPLANKPG HHHCCCCCCCCCCCC	20.30	OGP
1018	Phosphorylation	VRQDGGKSRLKKSQF EECCCCCHHHHHHHH	46.23	28258704
1023	Phosphorylation	GKSRLKKSQFLIKTR CCHHHHHHHHHHHCC	25.28	28258704
1029	Phosphorylation	KSQFLIKTRKKKKEK HHHHHHHCCCCCCCC	40.50	28258704
1038	Phosphorylation	KKKKEKHTHHAPLSP CCCCCCCCCCCCCCH	26.82	22964224
1044	O-linked_Glycosylation	HTHHAPLSPRTFHPL CCCCCCCCHHHCCCC	15.98	OGP
1044	Phosphorylation	HTHHAPLSPRTFHPL CCCCCCCCHHHCCCC	15.98	28270605
1047	Phosphorylation	HAPLSPRTFHPLRSE CCCCCHHHCCCCCCH	29.67	18491316
1053	O-linked_Glycosylation	RTFHPLRSEAYNTFS HHCCCCCCHHCCCCC	33.97	OGP
1053	Phosphorylation	RTFHPLRSEAYNTFS HHCCCCCCHHCCCCC	33.97	18491316
1056	Phosphorylation	HPLRSEAYNTFSERR CCCCCHHCCCCCHHH	15.64	18491316
1058	Phosphorylation	LRSEAYNTFSERRLK CCCHHCCCCCHHHHH	18.83	18491316
1067	Phosphorylation	SERRLKHSLVLHKSN CHHHHHEEEEEECCC	20.70	28270605
1074	N-linked_Glycosylation	SLVLHKSNETSLPTD EEEEECCCCCCCCCC	62.46	UniProtKB CARBOHYD
1083	N-linked_Glycosylation	TSLPTDLNQTLPSMD CCCCCCHHHCCCCCC	35.28	UniProtKB CARBOHYD
1103	N-linked_Glycosylation	SLPDHNQNSSNDTGQ CCCCCCCCCCCCCCC	53.36	UniProtKB CARBOHYD
1106	N-linked_Glycosylation	DHNQNSSNDTGQASC CCCCCCCCCCCCCCC	51.16	UniProtKB CARBOHYD
1120	O-linked_Glycosylation	CPPGLYQTVPPEEHY CCCCCEECCCCHHHH	22.79	OGP
1129	O-linked_Glycosylation	PPEEHYQTFPIQDPD CCHHHHCCCCCCCHH	24.98	OGP
1148	O-linked_Glycosylation	TSDPSHRSSSPELSE CCCCCCCCCCHHHHH	29.73	OGP
1148	Phosphorylation	TSDPSHRSSSPELSE CCCCCCCCCCHHHHH	29.73	27130503
1149	O-linked_Glycosylation	SDPSHRSSSPELSEM CCCCCCCCCHHHHHH	50.28	OGP
1149	Phosphorylation	SDPSHRSSSPELSEM CCCCCCCCCHHHHHH	50.28	24505115
1150	O-linked_Glycosylation	DPSHRSSSPELSEML CCCCCCCCHHHHHHH	24.52	OGP
1150	Phosphorylation	DPSHRSSSPELSEML CCCCCCCCHHHHHHH	24.52	27130503
1154	O-linked_Glycosylation	RSSSPELSEMLEYDR CCCCHHHHHHHHHHH	21.21	OGP
1154	Phosphorylation	RSSSPELSEMLEYDR CCCCHHHHHHHHHHH	21.21	28060719
1159	Phosphorylation	ELSEMLEYDRSHKSF HHHHHHHHHHCCCCC	16.82	28060719
1162	O-linked_Glycosylation	EMLEYDRSHKSFPTD HHHHHHHCCCCCCCC	32.16	OGP
1162	Phosphorylation	EMLEYDRSHKSFPTD HHHHHHHCCCCCCCC	32.16	28060719
1194	O-linked_Glycosylation	SPDLSQVTLSPELSQ CCCHHHCCCCHHHHC	17.55	OGP
1200	O-linked_Glycosylation	VTLSPELSQTNLSPD CCCCHHHHCCCCCCC	33.04	OGP
1202	O-linked_Glycosylation	LSPELSQTNLSPDLS CCHHHHCCCCCCCCC	34.45	OGP
1211	O-linked_Glycosylation	LSPDLSHTTLSPELI CCCCCCCCCCCHHHH	26.51	OGP
1212	O-linked_Glycosylation	SPDLSHTTLSPELIQ CCCCCCCCCCHHHHH	21.58	OGP
1223	O-linked_Glycosylation	ELIQRNLSPALGQMP HHHHCCCCHHHCCCC	16.21	OGP
1238	O-linked_Glycosylation	ISPDLSHTTLSPDLS CCCCCCCCCCCCCCC	26.51	OGP
1239	O-linked_Glycosylation	SPDLSHTTLSPDLSH CCCCCCCCCCCCCCC	21.58	OGP
1247	O-linked_Glycosylation	LSPDLSHTTLSLDLS CCCCCCCCEEEEECH	26.51	OGP
1263	O-linked_Glycosylation	TNLSPELSQTNLSPA CCCCHHHHCCCCCHH	33.04	OGP
1265	O-linked_Glycosylation	LSPELSQTNLSPALG CCHHHHCCCCCHHHC	34.45	OGP
1268	O-linked_Glycosylation	ELSQTNLSPALGQMP HHHCCCCCHHHCCCC	15.36	OGP
1284	O-linked_Glycosylation	SPDLSHTTLSLDFSQ CCCCCCCEEEECCCC	14.66	OGP
1290	O-linked_Glycosylation	TTLSLDFSQTNLSPE CEEEECCCCCCCCHH	35.44	OGP
1292	O-linked_Glycosylation	LSLDFSQTNLSPELS EEECCCCCCCCHHHH	36.61	OGP
1308	O-linked_Glycosylation	MTLSPELSQTNLSPA CCCCHHHHCCCCCHH	33.04	OGP
1310	O-linked_Glycosylation	LSPELSQTNLSPALG CCHHHHCCCCCHHHC	34.45	OGP
1329	O-linked_Glycosylation	SPDLSHTTLSLDFSQ CCCCCCCEEEECCCC	14.66	OGP
1410	O-linked_Glycosylation	TPDLDQMTLSPDLGE CCCHHHCCCCCCCCC	20.60	OGP
1418	O-linked_Glycosylation	LSPDLGETDLSPNFG CCCCCCCCCCCCCCC	40.20	OGP
1479	N-linked_Glycosylation	SLLLQEFNESFPYPD HHHHHHHHHCCCCCC	43.16	UniProtKB CARBOHYD
1499	N-linked_Glycosylation	SPSSPTLNDTFLSKE CCCCCCCCCCHHCCC	49.07	UniProtKB CARBOHYD
1516	O-linked_Glycosylation	PLVIVGLSKDGTDYI CEEEEEECCCCCCEE	23.83	29351928
1516	Phosphorylation	PLVIVGLSKDGTDYI CEEEEEECCCCCCEE	23.83	28270605
1520	Phosphorylation	VGLSKDGTDYIEIIP EEECCCCCCEEEECC	35.44	24505115
1522	Sulfation	LSKDGTDYIEIIPKE ECCCCCCEEEECCHH	10.57	-
1522	Sulfation	LSKDGTDYIEIIPKE ECCCCCCEEEECCHH	10.57	-
1533	Phosphorylation	IPKEEVQSSEDDYAE CCHHHHCCCCCCCCC	40.65	26657352
1534	Phosphorylation	PKEEVQSSEDDYAEI CHHHHCCCCCCCCCC	28.14	28270605
1538	Phosphorylation	VQSSEDDYAEIDYVP HCCCCCCCCCCCCCC	20.61	28270605
1538	Sulfation	VQSSEDDYAEIDYVP HCCCCCCCCCCCCCC	20.61	-
1538	Sulfation	VQSSEDDYAEIDYVP HCCCCCCCCCCCCCC	20.61	-
1543	Sulfation	DDYAEIDYVPYDDPY CCCCCCCCCCCCCCC	14.69	-
1543	Sulfation	DDYAEIDYVPYDDPY CCCCCCCCCCCCCCC	14.69	-
1559	N-linked_Glycosylation	TDVRTNINSSRDPDN CCCCCCCCCCCCCCC	35.68	16335952
1593	Sulfation	AEEISWDYSEFVQRE EEEEECCHHHHHHHC	12.11	-
1593	Sulfation	AEEISWDYSEFVQRE EEEEECCHHHHHHHC	12.11	-
1606	Phosphorylation	RETDIEDSDDIPEDT HCCCCCCCCCCCCCC	25.13	24505115
1623	Phosphorylation	KKVVFRKYLDSTFTK EEHHHHHHHHCCCCC	16.10	-
1626	Phosphorylation	VFRKYLDSTFTKRDP HHHHHHHCCCCCCCC	23.87	29759185
1627	Phosphorylation	FRKYLDSTFTKRDPR HHHHHHCCCCCCCCC	34.68	-
1629	Phosphorylation	KYLDSTFTKRDPRGE HHHHCCCCCCCCCCC	25.84	29759185
1676	Phosphorylation	SLHAHGLSYEKSSEG EEEECCCCCCCCCCC	35.52	-
1685	Phosphorylation	EKSSEGKTYEDDSPE CCCCCCCCCCCCCCH	42.89	-
1690	Phosphorylation	GKTYEDDSPEWFKED CCCCCCCCCHHHHHC	36.72	29970186
1703	N-linked_Glycosylation	EDNAVQPNSSYTYVW HCCCCCCCCCEEEEE	26.88	10521265
1703	N-linked_Glycosylation	EDNAVQPNSSYTYVW HCCCCCCCCCEEEEE	26.88	10521265
1775	Phosphorylation	EFVLLFMTFDEKKSW HHHHHHEECCCCCCC	22.17	28509920
1783	Phosphorylation	FDEKKSWYYEKKSRS CCCCCCCEEEECCCC	14.61	-
1784	Phosphorylation	DEKKSWYYEKKSRSS CCCCCCEEEECCCCC	18.27	-
1795	Phosphorylation	SRSSWRLTSSEMKKS CCCCEECCHHHHHHH	22.95	28060719
1796	Phosphorylation	RSSWRLTSSEMKKSH CCCEECCHHHHHHHH	28.97	28060719
1797	Phosphorylation	SSWRLTSSEMKKSHE CCEECCHHHHHHHHH	36.15	28060719
1949	Phosphorylation	GGSYNAWSVEKLAAE CCCCCCCCHHHHHHH	20.28	24505115
1984	Phosphorylation	QTQGAKHYLKSCYTT CCCCHHHHHHHCEEE	18.34	26074081
1987	Phosphorylation	GAKHYLKSCYTTEFY CHHHHHHHCEEEEEE	15.12	26074081
1989	Phosphorylation	KHYLKSCYTTEFYVA HHHHHHCEEEEEEEE	24.64	26074081
1990	Phosphorylation	HYLKSCYTTEFYVAY HHHHHCEEEEEEEEE	24.95	26074081
1991	Phosphorylation	YLKSCYTTEFYVAYS HHHHCEEEEEEEEEE	9.53	26074081
1994	Phosphorylation	SCYTTEFYVAYSSNQ HCEEEEEEEEEECCE	4.30	26074081
1997	Phosphorylation	TTEFYVAYSSNQINW EEEEEEEEECCEEEE	11.55	26074081
1998	Phosphorylation	TEFYVAYSSNQINWQ EEEEEEEECCEEEEE	17.05	26074081
1999	Phosphorylation	EFYVAYSSNQINWQI EEEEEEECCEEEEEE	21.78	26074081
2010	N-linked_Glycosylation	NWQIFKGNSTRNVMY EEEEEECCCCCCEEE	40.58	10521265
2010	N-linked_Glycosylation	NWQIFKGNSTRNVMY EEEEEECCCCCCEEE	40.58	10521265
2011	Phosphorylation	WQIFKGNSTRNVMYF EEEEECCCCCCEEEE	37.10	-
2026	Phosphorylation	NGNSDASTIKENQFD CCCCCHHHCCCCCCC	37.48	-
2149	Phosphorylation	KSLSSEMYVKSYTIH CCCCCCEEEEEEEEE	10.73	-
2158	Phosphorylation	KSYTIHYSEQGVEWK EEEEEEECCCCCCCC	14.85	-
2181	N-linked_Glycosylation	VDKIFEGNTNTKGHV HHHHHCCCCCCCCCH	23.98	-
2181	N-linked_Glycosylation	VDKIFEGNTNTKGHV HHHHHCCCCCCCCCH	23.98	10521265
2198	Phosphorylation	FFNPPIISRFIRVIP HCCHHHHHHHHEECC	23.12	-
2209	N-linked_Glycosylation	RVIPKTWNQSIALRL EECCCCCCHHHHHHH	30.84	UniProtKB CARBOHYD
2209	N-linked_Glycosylation	RVIPKTWNQSIALRL EECCCCCCHHHHHHH	30.84	10521265
2211	Phosphorylation	IPKTWNQSIALRLEL CCCCCCHHHHHHHHH	13.45	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
692	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
692	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
720	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
859	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
528	Phosphorylation	534 (6)	R ⇒ Q	rs6025	Venous thromboembolism Inflammatory bowel disease	22672568 25772935 26192919 26908601 28373160
859	Phosphorylation	858;865 (1;6)	K;H ⇒ R	rs4524;rs4525	Venous thromboembolism Blood protein levels	25772935 28240269
864	Acetylation	858;865 (6;1)	K;H ⇒ R	rs4524;rs4525	Venous thromboembolism Blood protein levels	25772935 28240269
866	Acetylation	858;865 (8;1)	K;H ⇒ R	rs4524;rs4525	Venous thromboembolism Blood protein levels	25772935 28240269
2149	Phosphorylation	2148 (1)	M ⇒ T	rs9332701	Blood protein levels	28240269
2158	Phosphorylation	2148 (10)	M ⇒ T	rs9332701	Blood protein levels	28240269

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PROS_HUMAN	PROS1	physical	8428962
FA5_HUMAN	F5	physical	10586886

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
227400	Factor V deficiency (FA5D)
188055	Thrombophilia due to activated protein C resistance (THPH2)
600880	Budd-Chiari syndrome (BDCHS)
601367	Ischemic stroke (ISCHSTR)
614389	Pregnancy loss, recurrent, 1 (RPRGL1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FA5_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Elucidation of N-glycosylation sites on human platelet proteins: aglycoproteomic approach."; Lewandrowski U., Moebius J., Walter U., Sickmann A.; Mol. Cell. Proteomics 5:226-233(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-297, AND MASSSPECTROMETRY.	16263699 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-297; ASN-460; ASN-821;ASN-977 AND ASN-1559, AND MASS SPECTROMETRY.	16335952 [Abstract]
Phosphorylation
Reference	PubMed
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1150, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-640, AND MASSSPECTROMETRY.	19690332 [Abstract]