| UniProt ID | SPDEF_HUMAN | |
|---|---|---|
| UniProt AC | O95238 | |
| Protein Name | SAM pointed domain-containing Ets transcription factor | |
| Gene Name | SPDEF | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 335 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.. | |
| Protein Sequence | MGSASPGLSSVSPSHLLLPPDTVSRTGLEKAAAGAVGLERRDWSPSPPATPEQGLSAFYLSYFDMLYPEDSSWAAKAPGASSREEPPEEPEQCPVIDSQAPAGSLDLVPGGLTLEEHSLEQVQSMVVGEVLKDIETACKLLNITADPMDWSPSNVQKWLLWTEHQYRLPPMGKAFQELAGKELCAMSEEQFRQRSPLGGDVLHAHLDIWKSAAWMKERTSPGAIHYCASTSEESWTDSEVDSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MGSASPGLSS -----CCCCCCCCCC | 25.03 | 25849741 | |
| 5 | Phosphorylation | ---MGSASPGLSSVS ---CCCCCCCCCCCC | 22.62 | 25849741 | |
| 9 | Phosphorylation | GSASPGLSSVSPSHL CCCCCCCCCCCHHHC | 34.31 | 28348404 | |
| 10 | Phosphorylation | SASPGLSSVSPSHLL CCCCCCCCCCHHHCC | 31.49 | 30243723 | |
| 12 | Phosphorylation | SPGLSSVSPSHLLLP CCCCCCCCHHHCCCC | 23.72 | 30243723 | |
| 14 | Phosphorylation | GLSSVSPSHLLLPPD CCCCCCHHHCCCCCC | 21.18 | 28348404 | |
| 24 | Phosphorylation | LLPPDTVSRTGLEKA CCCCCCCCCCCHHHH | 26.64 | 30576142 | |
| 219 | Phosphorylation | AAWMKERTSPGAIHY HHHHHHCCCCCCEEE | 40.12 | 28348404 | |
| 220 | Phosphorylation | AWMKERTSPGAIHYC HHHHHCCCCCCEEEE | 27.79 | 28348404 | |
| 226 | Phosphorylation | TSPGAIHYCASTSEE CCCCCEEEEECCCCC | 5.43 | 28348404 | |
| 229 | Phosphorylation | GAIHYCASTSEESWT CCEEEEECCCCCCCC | 28.98 | 28348404 | |
| 230 | Phosphorylation | AIHYCASTSEESWTD CEEEEECCCCCCCCC | 22.95 | 28348404 | |
| 231 | Phosphorylation | IHYCASTSEESWTDS EEEEECCCCCCCCCC | 36.55 | 28348404 | |
| 234 | Phosphorylation | CASTSEESWTDSEVD EECCCCCCCCCCCCC | 31.09 | 28348404 | |
| 236 | Phosphorylation | STSEESWTDSEVDSS CCCCCCCCCCCCCCC | 38.64 | 28348404 | |
| 238 | Phosphorylation | SEESWTDSEVDSSCS CCCCCCCCCCCCCCC | 31.95 | - | |
| 242 | Phosphorylation | WTDSEVDSSCSGQPI CCCCCCCCCCCCCCC | 38.12 | - | |
| 243 | Phosphorylation | TDSEVDSSCSGQPIH CCCCCCCCCCCCCCH | 14.08 | - | |
| 264 | Phosphorylation | ELLLKPHSYGRFIRW HHCCCCCCHHHHHHH | 37.50 | 24719451 | |
| 265 | Phosphorylation | LLLKPHSYGRFIRWL HCCCCCCHHHHHHHH | 14.86 | 24719451 | |
| 302 | Phosphorylation | KNRPAMNYDKLSRSI CCCCCCCHHHHHHHH | 11.02 | 22817900 | |
| 308 | Phosphorylation | NYDKLSRSIRQYYKK CHHHHHHHHHHHHHC | 20.81 | 25954137 | |
| 329 | Phosphorylation | DISQRLVYQFVHPI- CHHHHHHHHHCCCC- | 10.79 | 26356563 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPDEF_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPDEF_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NKX31_HUMAN | NKX3-1 | physical | 11809674 | |
| U119A_HUMAN | UNC119 | physical | 26186194 | |
| PRD16_HUMAN | PRDM16 | physical | 26186194 | |
| EVI1_HUMAN | MECOM | physical | 26186194 | |
| MYO5C_HUMAN | MYO5C | physical | 26186194 | |
| B3A2_HUMAN | SLC4A2 | physical | 26186194 | |
| ZNT9_HUMAN | SLC30A9 | physical | 26186194 | |
| FAKD1_HUMAN | FASTKD1 | physical | 26186194 | |
| CE030_HUMAN | C5orf30 | physical | 26186194 | |
| PRD16_HUMAN | PRDM16 | physical | 28514442 | |
| EVI1_HUMAN | MECOM | physical | 28514442 | |
| CE030_HUMAN | C5orf30 | physical | 28514442 | |
| MYO5C_HUMAN | MYO5C | physical | 28514442 | |
| FAKD1_HUMAN | FASTKD1 | physical | 28514442 | |
| B3A2_HUMAN | SLC4A2 | physical | 28514442 | |
| ANM8_HUMAN | PRMT8 | physical | 28514442 | |
| U119A_HUMAN | UNC119 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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