| UniProt ID | ZNT9_HUMAN | |
|---|---|---|
| UniProt AC | Q6PML9 | |
| Protein Name | Zinc transporter 9 | |
| Gene Name | SLC30A9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 568 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . Nucleus . Cytoplasm . Cytoplasmic vesicle . Endoplasmic reticulum . Mainly in the cytoplasm (PubMed:10409434). Partial co-localization with endoplasmic reticulum (PubMed:28334855). |
|
| Protein Description | Acts as a zinc transporter involved in intracellular zinc homeostasis. [PubMed: 28334855 Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity] | |
| Protein Sequence | MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGTLSQVKLYSTNVQKEGQGSQTLRVEKVPSFETAEGIGTELKAPLKQEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHEDTESFTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNPLYDSLGSLGVGTLLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIIDTLGAEVDRLEKELKKRNPEVRHVDLEIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 73 | Ubiquitination | LYSTNVQKEGQGSQT EEECCCCCCCCCCCE | 60.57 | - | |
| 88 | Phosphorylation | LRVEKVPSFETAEGI EEEEECCCCCCCCCC | 38.41 | 26471730 | |
| 183 | Phosphorylation | KSLEVWGSPEALARE HHEEECCCHHHHHHH | 12.12 | 26471730 | |
| 222 | Phosphorylation | YRDFLGNTKPRSRTA HHHHHCCCCCCCCEE | 40.40 | - | |
| 223 | Ubiquitination | RDFLGNTKPRSRTAS HHHHCCCCCCCCEEE | 42.29 | - | |
| 230 | Phosphorylation | KPRSRTASVFFKGPG CCCCCEEEEEEECCC | 20.88 | - | |
| 303 | Phosphorylation | PSHPYGFSNMRYISS CCCCCCCCCHHHHHH | 25.92 | 24719451 | |
| 374 | Malonylation | LRRNARAKGMSFYKY HHHHHHHCCCCHHHH | 49.98 | 26320211 | |
| 471 | Phosphorylation | ELLENDPSVRAIHDV HHHHCCCCCHHHEEE | 27.39 | 29449344 | |
| 479 | Ubiquitination | VRAIHDVKATDLGLG CHHHEEEECCCCCCC | 52.18 | - | |
| 479 | 2-Hydroxyisobutyrylation | VRAIHDVKATDLGLG CHHHEEEECCCCCCC | 52.18 | - | |
| 479 | Malonylation | VRAIHDVKATDLGLG CHHHEEEECCCCCCC | 52.18 | 26320211 | |
| 487 | Ubiquitination | ATDLGLGKVRFKAEV CCCCCCCEEEEEEEE | 34.97 | - | |
| 487 | Malonylation | ATDLGLGKVRFKAEV CCCCCCCEEEEEEEE | 34.97 | 26320211 | |
| 541 | O-linked_Glycosylation | HGENIIDTLGAEVDR HCCCHHHHHHHHHHH | 19.38 | OGP |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZNT9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZNT9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZNT9_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ZNT9_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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