FBX24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX24_HUMAN
• UniProt AC: O75426
• Protein Name: F-box only protein 24
• Gene Name: FBXO24
• Organism: Homo sapiens (Human).
• Sequence Length: 580
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
• Protein Sequence: MGEKAVPLLRRRRVKRSCPSCGSELGVEEKRGKGNPISIQLFPPELVEHIISFLPVRDLVALGQTCRYFHEVCDGEGVWRRICRRLSPRLQDQGSGVRPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPLLAHGYRRFLPTKDHVFILDYVGTLFFLKNALVSTLGQMQWKRACRYVVLCRGAKDFASDPRCDTVYRKYLYVLATREPQEVVGTTSSRACDCVEVYLQSSGQRVFKMTFHHSMTFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSHYLPHLRVACMTSNQSSTLYVTDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQRPITLWCGLNHSLVLSQSSEFSKELLGCGCGAGGRLPGWPKGSASFVKLQVKVPLCACALCATRECLYILSSHDIEQHAPYRHLPASRVVGTPEPSLGARAPQDPGGMAQACEEYLSQIHSCQTLQDRTEKMKEIVGWMPLMAAQKDFFWEALDMLQRAEGGGGGVGPPAPET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	RVKRSCPSCGSELGV HCHHHCCCCCCCCCC	35.12	30622161
23	Phosphorylation	RSCPSCGSELGVEEK HHCCCCCCCCCCCCC	33.69	30622161
108	Phosphorylation	KRAAILNYTKGLYFQ HHHHHHHHCCCEEHH	13.34	-
109	Phosphorylation	RAAILNYTKGLYFQA HHHHHHHCCCEEHHC	19.98	27499020
136	Phosphorylation	APLLAHGYRRFLPTK HHHHHCCHHHCCCCC	6.69	27273156
147	Phosphorylation	LPTKDHVFILDYVGT CCCCCEEEEECHHHH	4.05	27251275
227	Phosphorylation	ACDCVEVYLQSSGQR CCCEEEEEEECCCCE	5.87	-
230	Phosphorylation	CVEVYLQSSGQRVFK EEEEEEECCCCEEEE	33.56	-
245	Phosphorylation	MTFHHSMTFKQIVLV EEEECCCEEEEEEEE	30.60	-
286	Phosphorylation	LDQPRSYTVQLALRK CCCCCCHHHHHHHHH	11.74	-
450	Phosphorylation	LPGWPKGSASFVKLQ CCCCCCCCCCEEEEE	27.19	25690035
452	Phosphorylation	GWPKGSASFVKLQVK CCCCCCCCEEEEEEH	32.06	25690035

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX24_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDKA_HUMAN	NME1	physical	25582197
SKP1_HUMAN	SKP1	physical	25582197
CUL1_HUMAN	CUL1	physical	25582197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.