LRC52_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC52_HUMAN
• UniProt AC: Q8N7C0
• Protein Name: Leucine-rich repeat-containing protein 52
• Gene Name: LRRC52
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Cell membrane; Single-pass membrane protein. Expression at the cell surface may require the presence of KCNU1.
• Protein Description: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties..
• Protein Sequence: MSLASGPGPGWLLFSFGMGLVSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIFQTQTSSVQEFPQLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	N-linked_Glycosylation	YLDLSSNNLTSISPF EEECCCCCCCCCCHH	46.79	UniProtKB CARBOHYD
148	N-linked_Glycosylation	LHKFTFANTTSLRYL EEEEEECCCCCCEEE	39.43	UniProtKB CARBOHYD
150	Phosphorylation	KFTFANTTSLRYLDL EEEECCCCCCEEEEC	26.10	23532336
189	N-linked_Glycosylation	SGNPWKCNCSFLDFA CCCCCCCCCCHHHHE	22.27	UniProtKB CARBOHYD
211	N-linked_Glycosylation	MDPSDDLNATCVEPT CCCCCCCCCEEECCC	39.95	UniProtKB CARBOHYD
301	Phosphorylation	VSRRIFQTQTSSVQE HHHHHHCCCCCCHHH	24.06	25693802
303	Phosphorylation	RRIFQTQTSSVQEFP HHHHCCCCCCHHHCC	26.76	25693802
304	Phosphorylation	RIFQTQTSSVQEFPQ HHHCCCCCCHHHCCC	20.77	25693802
305	Phosphorylation	IFQTQTSSVQEFPQL HHCCCCCCHHHCCCC	31.07	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC52_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC52_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC52_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LRC52_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.