SYCP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYCP2_HUMAN
• UniProt AC: Q9BX26
• Protein Name: Synaptonemal complex protein 2
• Gene Name: SYCP2
• Organism: Homo sapiens (Human).
• Sequence Length: 1530
• Subcellular Localization: Nucleus . Chromosome . In axial/lateral elements of the tripartite segments of synaptonemal complexes.
• Protein Description: Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements..
• Protein Sequence: MPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHNVSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRICSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFIAKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPEEKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPESQISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQMTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDNICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQQQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQKKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNLNGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLIDYSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIHSRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSSLESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESPHINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADHHIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNIRHKMLSYFTTQSWKTAQQHLRTMNHQSQDSRIKKLDKFQFIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSAYQKSEQQRLHLLKTSLAKSVFCNTDSEETVFTSEMCLMKEDMKVLQDRLLKDMLEEELLNVRRELMSVFMSHERNANV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
201	Phosphorylation	QEMLILMSSMGERIL HHHHHHHHHCCCHHH	17.46	24043423
202	Phosphorylation	EMLILMSSMGERILD HHHHHHHHCCCHHHC	19.49	24043423
332	Phosphorylation	DHQWEAVTVPEEKVQ CCCEEEEECCHHHEE	37.07	22210691
342	Phosphorylation	EEKVQIYSIEVRESK HHHEEEEEEEEECCH	17.57	22210691
357	Acetylation	KLLTIILKNTVKISK HHHEEHHHCCEEECH	39.92	30592729
361	Acetylation	IILKNTVKISKREGK EHHHCCEEECHHCCC	38.94	30592735
436	Phosphorylation	PVGEELVSLKEKSKS CCCHHHCHHHHHCCC	46.47	-
457	Phosphorylation	PSKYIKNSDKGNRNN CHHHCCCCCCCCCCC	35.38	-
465	Phosphorylation	DKGNRNNSQLEKTTP CCCCCCCHHHCCCCC	39.43	-
470	Phosphorylation	NNSQLEKTTPSKRKM CCHHHCCCCCCHHCC	34.27	17322306
471	Phosphorylation	NSQLEKTTPSKRKMS CHHHCCCCCCHHCCC	36.31	22817900
478	Phosphorylation	TPSKRKMSEASMIVS CCCHHCCCCHHEEEC	32.80	20363803
481	Phosphorylation	KRKMSEASMIVSGAD HHCCCCHHEEECCCC	12.65	-
485	Phosphorylation	SEASMIVSGADRYTM CCHHEEECCCCCCCC	19.83	-
494	Phosphorylation	ADRYTMRSPVLFSNT CCCCCCCCCEECCCC	14.45	26552605
499	Phosphorylation	MRSPVLFSNTSIPPR CCCCEECCCCCCCCC	34.73	26552605
501	Phosphorylation	SPVLFSNTSIPPRRR CCEECCCCCCCCCCC	27.17	26552605
502	Phosphorylation	PVLFSNTSIPPRRRR CEECCCCCCCCCCCC	37.03	26552605
519	Phosphorylation	PPLQMTSSAEKPSVS CCCCCCCCCCCCCCC	31.14	-
529	Phosphorylation	KPSVSQTSENRVDNA CCCCCCCCCCCCCCH	25.82	-
538	Phosphorylation	NRVDNAASLKSRSSE CCCCCHHHHHCCCCC	33.64	-
543	Phosphorylation	AASLKSRSSEGRHRR HHHHHCCCCCCCCCH	39.57	-
544	Phosphorylation	ASLKSRSSEGRHRRD HHHHCCCCCCCCCHH	42.85	-
619	Phosphorylation	HSKWACWTPVTNIEL CCCCCEECCCCCEEE	14.04	-
660	Phosphorylation	QKSSSSISDHNSEGT CCCCCCCCCCCCCCC	34.46	-
664	Phosphorylation	SSISDHNSEGTGKVK CCCCCCCCCCCCCCE	33.70	-
681	Ubiquitination	KEQTDHIKIDKAEVE CCCCCCCEECHHHHH	41.24	-
743	Phosphorylation	SLIYRKKYILSKDVN HHHHHHHEEECCCCC	15.32	17081983
798	Phosphorylation	KSKGKEFTNVAESLI HHCCHHHHHHHHHHH	29.85	29978859
803	Phosphorylation	EFTNVAESLISQINK HHHHHHHHHHHHHHH	22.67	29978859
806	Phosphorylation	NVAESLISQINKRYK HHHHHHHHHHHHHCC	30.24	29978859
927	Phosphorylation	TKDKKIITNHQKKNL CCCCEECCCCHHCCC	30.07	29978859
936	Phosphorylation	HQKKNLFSDTETEYR CHHCCCCCCCCCEEE	46.95	29978859
938	Phosphorylation	KKNLFSDTETEYRCD HCCCCCCCCCEEECC	43.54	29978859
940	Phosphorylation	NLFSDTETEYRCDDS CCCCCCCCEEECCCC	40.17	29978859
942	Phosphorylation	FSDTETEYRCDDSKT CCCCCCEEECCCCCC	24.78	29978859
966	Phosphorylation	SKPQLIDYSRNKNVK CCCCCCCCCCCCCCC	11.53	23312004
967	Phosphorylation	KPQLIDYSRNKNVKN CCCCCCCCCCCCCCC	26.15	23312004
992	Acetylation	EKGQPSSKMTPSKNI CCCCCCCCCCCCCCC	51.64	7977321
1019	Phosphorylation	IRLPRKATKTKKNYK CCCCCCCCCCCCCHH	42.13	-
1021	Phosphorylation	LPRKATKTKKNYKDL CCCCCCCCCCCHHHC	42.78	-
1040	Phosphorylation	SECEQEFSHSFKENI HHHHHHHHHHHHHCC	19.92	-
1042	Phosphorylation	CEQEFSHSFKENIPV HHHHHHHHHHHCCCC	36.49	-
1056	Phosphorylation	VKEENIHSRMKTVKL CCCCHHHHCCCCCCC	30.21	-
1060	Phosphorylation	NIHSRMKTVKLPKKQ HHHHCCCCCCCCHHH	17.33	-
1065	Acetylation	MKTVKLPKKQQKVFC CCCCCCCHHHCCEEE	73.90	7851919
1066	Acetylation	KTVKLPKKQQKVFCA CCCCCCHHHCCEEEH	56.90	7851927
1087	Phosphorylation	SKQWKNSSLLKDAIR HHHHHCCHHHHHHHH	47.30	24719451
1101	Phosphorylation	RDNCLDLSPRSLSGS HHCCCCCCCCCCCCC	20.24	24719451
1110	Phosphorylation	RSLSGSPSSIEVTRC CCCCCCCCHHHHHHH	45.72	24719451
1111	Phosphorylation	SLSGSPSSIEVTRCI CCCCCCCHHHHHHHH	26.59	-
1130	Phosphorylation	EKDFTQDYDCITKSI CCCCCCCCCCCCCCC	11.69	22817900
1136	Phosphorylation	DYDCITKSISPYPKT CCCCCCCCCCCCCCC	21.46	26307563
1138	Phosphorylation	DCITKSISPYPKTSS CCCCCCCCCCCCCCC	26.02	25056879
1140	Phosphorylation	ITKSISPYPKTSSLE CCCCCCCCCCCCCCH	15.57	22817900
1145	Phosphorylation	SPYPKTSSLESLNSN CCCCCCCCCHHCCCC	41.19	-
1161	Phosphorylation	GVGGTIKSPKNNEKN CCCCCCCCCCCCCCC	36.94	-
1177	Phosphorylation	LCASESCSPIPRPLF EEECCCCCCCCCCCC	34.83	24719451
1189	Phosphorylation	PLFLPRHTPTKSNTI CCCCCCCCCCCCCCE	33.65	-
1204	Phosphorylation	VNRKKISSLVLTQET ECHHHCCEEEEEECC	26.43	-
1234	Phosphorylation	ERFMEIESPHINENY HHCCCCCCCCCCHHH	27.69	-
1241	Phosphorylation	SPHINENYIQSKREE CCCCCHHHHHCHHHH	8.31	-
1249	Phosphorylation	IQSKREESHLASSLS HHCHHHHHHHHHHCC	21.03	-
1253	Phosphorylation	REESHLASSLSKSSE HHHHHHHHHCCCCCC	37.87	-
1254	Phosphorylation	EESHLASSLSKSSEG HHHHHHHHCCCCCCC	30.93	-
1256	Phosphorylation	SHLASSLSKSSEGRE HHHHHHCCCCCCCCC	32.23	-
1295	Phosphorylation	IYIEDNLSNSNEVEM EEEECCCCCCCCCCC	44.46	-
1297	Phosphorylation	IEDNLSNSNEVEMEE EECCCCCCCCCCCHH	30.87	-
1339	Phosphorylation	ESVSSLSTNDFSIPW HHHHHCCCCCCCCCH	44.06	-
1368	Phosphorylation	ETYERLNSEFKRRNN HHHHHHHHHHHHHHC	49.34	28270605
1523	Phosphorylation	ELMSVFMSHERNANV HHHHHHHHHHHCCCC	15.67	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYCP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYCP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYCP2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SYCP2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.