ENOX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENOX2_HUMAN
• UniProt AC: Q16206
• Protein Name: Ecto-NOX disulfide-thiol exchanger 2
• Gene Name: ENOX2
• Organism: Homo sapiens (Human).
• Sequence Length: 610
• Subcellular Localization: Cell membrane. Secreted, extracellular space. Extracellular and plasma membrane-associated.
• Protein Description: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock..
• Protein Sequence: MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
240	Phosphorylation	EERLRPPSPPPVVHY HHHHCCCCCCCCCCC	53.36	23927012
247	Phosphorylation	SPPPVVHYSDHECSI CCCCCCCCCCCCCHH	12.27	23927012
248	Phosphorylation	PPPVVHYSDHECSIV CCCCCCCCCCCCHHH	20.01	23927012
285	Phosphorylation	RGEVNRRSANNFYSM HCCCCHHHCHHHHHH	31.92	22210691
290	Phosphorylation	RRSANNFYSMIQSAN HHHCHHHHHHHHHHH	10.23	22210691
291	Phosphorylation	RSANNFYSMIQSANS HHCHHHHHHHHHHHH	12.79	22210691
343	Phosphorylation	VAVYHSASKQKAWDH HHHHHCCCHHHHHHH	38.34	-
352	Phosphorylation	QKAWDHFTKAQRKNI HHHHHHHHHHHHHCH	23.27	24719451
360	Phosphorylation	KAQRKNISVWCKQAE HHHHHCHHHHHHCHH	20.96	18452278
389	Phosphorylation	REEEMEMSDDEIEEM CHHHCCCCHHHHHHH	28.71	25849741
420	Phosphorylation	ALKEENDSLRWQLDA HHHHHCCCHHHHHHH	31.26	-
428	Phosphorylation	LRWQLDAYRNEVELL HHHHHHHHHHHHHHH	17.40	-
436	Ubiquitination	RNEVELLKQEQGKVH HHHHHHHHHHCCCCC	65.50	-
489	Acetylation	LEKLKDDKLQVEKML HHHHHHCHHHHHHHH	51.45	7712319
504	Phosphorylation	ENLKEKESCASRLCA HHHHHHHHHHHHHHH	26.50	22659163
507	Phosphorylation	KEKESCASRLCASNQ HHHHHHHHHHHHCCC	30.07	22210691
527	Phosphorylation	LEKTMNSSPIKSERE HHHHCCCCCCCCHHH	26.16	22210691
531	Phosphorylation	MNSSPIKSEREALLV CCCCCCCCHHHHHHH	42.48	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
504	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENOX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENOX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ENOX1_HUMAN	ENOX1	physical	16189514
TBB4B_HUMAN	TUBB4B	physical	21988832
ENOX1_HUMAN	ENOX1	physical	25416956
CIB3_HUMAN	CIB3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.