| UniProt ID | ENOX1_HUMAN | |
|---|---|---|
| UniProt AC | Q8TC92 | |
| Protein Name | Ecto-NOX disulfide-thiol exchanger 1 | |
| Gene Name | ENOX1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 643 | |
| Subcellular Localization | Cell membrane . Secreted, extracellular space . Extracellular and plasma membrane-associated. | |
| Protein Description | Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.. | |
| Protein Sequence | MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 194 | Phosphorylation | FMVDKAIYLSGYRMR HHCCCCHHHCCCCEE | 10.32 | 26552605 | |
| 196 | Phosphorylation | VDKAIYLSGYRMRLG CCCCHHHCCCCEECC | 19.46 | 26552605 | |
| 198 | Phosphorylation | KAIYLSGYRMRLGSS CCHHHCCCCEECCCC | 9.62 | 26552605 | |
| 204 | Phosphorylation | GYRMRLGSSTDKKDS CCCEECCCCCCCCCC | 34.36 | 26552605 | |
| 205 | Phosphorylation | YRMRLGSSTDKKDSG CCEECCCCCCCCCCC | 38.54 | 25003641 | |
| 206 | Phosphorylation | RMRLGSSTDKKDSGR CEECCCCCCCCCCCC | 54.24 | 25003641 | |
| 254 | Phosphorylation | EDRLRPPSPPAIMHY HHCCCCCCCCCCCCC | 46.31 | 26471730 | |
| 262 | Phosphorylation | PPAIMHYSEHEAALL CCCCCCCCHHHHHHH | 20.14 | 27251275 | |
| 272 | Ubiquitination | EAALLAEKLKDDSKF HHHHHHHHHCCCCHH | 56.05 | - | |
| 288 | Phosphorylation | EAITVLLSWIERGEV HHHHHHHHHHHHCCC | 23.11 | 23927012 | |
| 299 | Phosphorylation | RGEVNRRSANQFYSM HCCCCHHHHHHHHHH | 28.47 | - | |
| 403 | Phosphorylation | REEEMEMSDDENCDS CHHHHCCCCCCCCCC | 28.71 | 29978859 | |
| 410 | Phosphorylation | SDDENCDSPTKKMRV CCCCCCCCCCHHCCC | 36.35 | 30576142 | |
| 412 | Phosphorylation | DENCDSPTKKMRVDE CCCCCCCCHHCCCCH | 47.45 | 20873877 | |
| 435 | Phosphorylation | ALKEENDSLRWQLDA HHHHHCCCHHHHHHH | 31.26 | - | |
| 443 | Phosphorylation | LRWQLDAYRNEVELL HHHHHHHHHHHHHHH | 17.40 | - | |
| 465 | Phosphorylation | FRTEENLTKDQQLQF HCCHHCCCHHHHHHH | 44.12 | 22817900 | |
| 476 | Phosphorylation | QLQFLQQTMQGMQQQ HHHHHHHHHHHHHHH | 9.86 | - | |
| 502 | Ubiquitination | KSELEQAKEEQSHTQ HHHHHHHHHHHHHHH | 62.57 | - | |
| 622 | Phosphorylation | RMFKQEFTGVGATLE HHHHHHHCCCCCCHH | 30.15 | - | |
| 627 | Phosphorylation | EFTGVGATLEKRWKL HHCCCCCCHHHHHHE | 29.53 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ENOX1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ENOX1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ENOX1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NIF3L_HUMAN | NIF3L1 | physical | 16189514 | |
| LNX1_HUMAN | LNX1 | physical | 16189514 | |
| EF1G_HUMAN | EEF1G | physical | 16169070 | |
| ZMY19_HUMAN | ZMYND19 | physical | 25416956 | |
| TRI43_HUMAN | TRIM43 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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