TGRM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGRM1_HUMAN
• UniProt AC: Q9Y4F4
• Protein Name: TOG array regulator of axonemal microtubules protein 1 {ECO:0000312|HGNC:HGNC:19959}
• Gene Name: TOGARAM1 {ECO:0000312|HGNC:HGNC:19959}
• Organism: Homo sapiens (Human).
• Sequence Length: 1720
• Subcellular Localization: Cell projection, cilium . Cytoplasm, cytoskeleton . Detected along the length of primary cilia and at the basal body. Colocalization with the cytoplasmic microtubule cytoskeleton upon heterologous expression is most likely an artifact.
• Protein Description: Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity)..
• Protein Sequence: MAAAPSALLLLPPFPVLSTYRLQSRSRPSAPETDDSRVGGIMRGEKNYYFRGAAGDHGSCPTTTSPLASALLMPSEAVSSSWSESGGGLSGGDEEDTRLLQLLRTARDPSEAFQALQAALPRRGGRLGFPRRKEALYRALGRVLVEGGSDEKRLCLQLLSDVLRGQGEAGQLEEAFSLALLPQLVVSLREENPALRKDALQILHICLKRSPGEVLRTLIQQGLESTDARLRASTALLLPILLTTEDLLLGLDLTEVIISLARKLGDQETEEESETAFSALQQIGERLGQDRFQSYISRLPSALRRHYNRRLESQFGSQVPYYLELEASGFPEDPLPCAVTLSNSNLKFGIIPQELHSRLLDQEDYKNRTQAVEELKQVLGKFNPSSTPHSSLVGFISLLYNLLDDSNFKVVHGTLEVLHLLVIRLGEQVQQFLGPVIAASVKVLADNKLVIKQEYMKIFLKLMKEVGPQQVLCLLLEHLKHKHSRVREEVVNICICSLLTYPSEDFDLPKLSFDLAPALVDSKRRVRQAALEAFAVLASSMGSGKTSILFKAVDTVELQDNGDGVMNAVQARLARKTLPRLTEQGFVEYAVLMPSSAGGRSNHLAHGADTDWLLAGNRTQSAHCHCGDHVRDSMHIYGSYSPTICTRRVLSAGKGKNKLPWENEQPGIMGENQTSTSKDIEQFSTYDFIPSAKLKLSQGMPVNDDLCFSRKRVSRNLFQNSRDFNPDCLPLCAAGTTGTHQTNLSGKCAQLGFSQICGKTGSVGSDLQFLGTTSSHQEKVYASLNFGSKTQQTFGSQTECTSSNGQNPSPGAYILPSYPVSSPRTSPKHTSPLIISPKKSQDNSVNFSNSWPLKSFEGLSKPSPQKKLVSQKSSDPTGRNHGENSQEKPPVQLTPALVRSPSSRRGLNGTKPVPPIPRGISLLPDKADLSTVGHKKKEPDDIWKCEKDSLPIDLSELNFKDKDLDQEEMHSSLRSLRNSAAKKRAKLSGSTSDLESPDSAMKLDLTMDSPSLSSSPNINSYSESGVYSQESLTSSLSTTPQGKRIMSDIFPTFGSKPCPTRLSSAKKKISHIAEQSPSAGSSSNPQQISSFDFTTTKALSEDSVVVVGKGVFGSLSSAPATCSQSVISSVENGDTFSIKQSIEPPSGIYGRSVQQNISSYLDVENEKDAKVSISKSTYNKMRQKRKEEKELFHNKDCEKKEKNSWERMRHTGTEKMASESETPTGAISQYKERMPSVTHSPEIMDLSELRPFSKPEIALTEALRLLADEDWEKKIEGLNFIRCLAAFHSEILNTKLHETNFAVVQEVKNLRSGVSRAAVVCLSDLFTYLKKSMDQELDTTVKVLLHKAGESNTFIREDVDKALRAMVNNVTPARAVVSLINGGQRYYGRKMLFFMMCHPNFEKMLEKYVPSKDLPYIKDSVRNLQQKGLGEIPLDTPSAKGRRSHTGSVGNTRSSSVSRDAFNSAERAVTEVREVTRKSVPRNSLESAEYLKLITGLLNAKDFRDRINGIKQLLSDTENNQDLVVGNIVKIFDAFKSRLHDSNSKVNLVALETMHKMIPLLRDHLSPIINMLIPAIVDNNLNSKNPGIYAAATNVVQALSQHVDNYLLLQPFCTKAQFLNGKAKQDMTEKLADIVTELYQRKPHATEQKVLVVLWHLLGNMTNSGSLPGAGGNIRTATAKLSKALFAQMGQNLLNQAASQPPHIKKSLEELLDMTILNEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	LSTYRLQSRSRPSAP EEHHCCCCCCCCCCC		30576142
27	Dimethylation	YRLQSRSRPSAPETD HCCCCCCCCCCCCCC		-
37	Dimethylation	APETDDSRVGGIMRG CCCCCCCCCCCCCCC		-
51	Dimethylation	GEKNYYFRGAAGDHG CCCCEEECCCCCCCC		-
366	Ubiquitination	LLDQEDYKNRTQAVE HCCHHHHHHHHHHHH		-
448	Ubiquitination	VKVLADNKLVIKQEY HHHHHCCCEEECHHH		-
637	Phosphorylation	VRDSMHIYGSYSPTI CCCCCEEECCCCCCC		28348404
639	Phosphorylation	DSMHIYGSYSPTICT CCCEEECCCCCCCCC		28348404
640	Phosphorylation	SMHIYGSYSPTICTR CCEEECCCCCCCCCH		28348404
641	Phosphorylation	MHIYGSYSPTICTRR CEEECCCCCCCCCHH		28348404
691	Phosphorylation	STYDFIPSAKLKLSQ HHCCCCCCCCEEHHC		24719451
693	Ubiquitination	YDFIPSAKLKLSQGM CCCCCCCCEEHHCCC		-
709	Phosphorylation	VNDDLCFSRKRVSRN CCCHHHHCCHHHHHH		24719451
760	Phosphorylation	FSQICGKTGSVGSDL CHHHCCCCCCCCCCC		28857561
762	Phosphorylation	QICGKTGSVGSDLQF HHCCCCCCCCCCCEE		25849741
765	Phosphorylation	GKTGSVGSDLQFLGT CCCCCCCCCCEECCC		28857561
772	Phosphorylation	SDLQFLGTTSSHQEK CCCEECCCCCCCCCE		23186163
773	Phosphorylation	DLQFLGTTSSHQEKV CCEECCCCCCCCCEE		23186163
774	Phosphorylation	LQFLGTTSSHQEKVY CEECCCCCCCCCEEE		23186163
775	Phosphorylation	QFLGTTSSHQEKVYA EECCCCCCCCCEEEE		23186163
836	Phosphorylation	HTSPLIISPKKSQDN CCCCEEECCCCCCCC		29255136
840	Phosphorylation	LIISPKKSQDNSVNF EEECCCCCCCCCCCC		25954137
844	Phosphorylation	PKKSQDNSVNFSNSW CCCCCCCCCCCCCCC		25954137
848	Phosphorylation	QDNSVNFSNSWPLKS CCCCCCCCCCCCCCC		28348404
850	Phosphorylation	NSVNFSNSWPLKSFE CCCCCCCCCCCCCCC		25954137
873	Phosphorylation	KKLVSQKSSDPTGRN HHHCCCCCCCCCCCC		24719451
971	Phosphorylation	LDQEEMHSSLRSLRN CCHHHHHHHHHHHHH		27251275
972	Phosphorylation	DQEEMHSSLRSLRNS CHHHHHHHHHHHHHH		27251275
988	Phosphorylation	AKKRAKLSGSTSDLE HHHHHHHCCCCCCCC		28348404
990	Phosphorylation	KRAKLSGSTSDLESP HHHHHCCCCCCCCCC		28348404
991	Phosphorylation	RAKLSGSTSDLESPD HHHHCCCCCCCCCCC		21815630
996	Phosphorylation	GSTSDLESPDSAMKL CCCCCCCCCCCCCCC		-
1055	Phosphorylation	DIFPTFGSKPCPTRL HCCCCCCCCCCCCCC		18187866
1064	Phosphorylation	PCPTRLSSAKKKISH CCCCCCHHHHHHHHH		-
1100	Phosphorylation	FTTTKALSEDSVVVV CCCCCCCCCCEEEEE		24719451
1103	Phosphorylation	TKALSEDSVVVVGKG CCCCCCCEEEEEECC		28348404
1172	Phosphorylation	NEKDAKVSISKSTYN CCCCCEEEECHHHHH		29978859
1174	Phosphorylation	KDAKVSISKSTYNKM CCCEEEECHHHHHHH		29978859
1176	Phosphorylation	AKVSISKSTYNKMRQ CEEEECHHHHHHHHH		29978859
1177	Phosphorylation	KVSISKSTYNKMRQK EEEECHHHHHHHHHH		29978859
1178	Phosphorylation	VSISKSTYNKMRQKR EEECHHHHHHHHHHH		29978859
1204	Phosphorylation	CEKKEKNSWERMRHT HHHHHHCHHHHHHHC		-
1230	Phosphorylation	PTGAISQYKERMPSV CCCHHHHHHHHCCCC		22468782
1236	Phosphorylation	QYKERMPSVTHSPEI HHHHHCCCCCCCCCC		22468782
1247	Phosphorylation	SPEIMDLSELRPFSK CCCCCCHHHCCCCCC		22468782
1289	Phosphorylation	RCLAAFHSEILNTKL HHHHHHHHHHHCCCC		-
1294	Phosphorylation	FHSEILNTKLHETNF HHHHHHCCCCCCCCC		-
1312	Phosphorylation	QEVKNLRSGVSRAAV HHHHHHCCCCCHHHH		-
1315	Phosphorylation	KNLRSGVSRAAVVCL HHHCCCCCHHHHHHH		-
1332	Phosphorylation	LFTYLKKSMDQELDT HHHHHHHHCCHHHHH		29523821
1339	Phosphorylation	SMDQELDTTVKVLLH HCCHHHHHHHHHHHH		29523821
1340	Phosphorylation	MDQELDTTVKVLLHK CCHHHHHHHHHHHHH		29523821
1351	Phosphorylation	LLHKAGESNTFIRED HHHHCCCCCCEEHHH		28355574
1353	Phosphorylation	HKAGESNTFIREDVD HHCCCCCCEEHHHHH		28355574
1403	Acetylation	MCHPNFEKMLEKYVP HHCCCHHHHHHHHCC		30588677
1436	Phosphorylation	LGEIPLDTPSAKGRR CCCCCCCCCCCCCCC		28348404
1438	Phosphorylation	EIPLDTPSAKGRRSH CCCCCCCCCCCCCCC		29759185
1448	Phosphorylation	GRRSHTGSVGNTRSS CCCCCCCCCCCCCCC		29449344
1452	Phosphorylation	HTGSVGNTRSSSVSR CCCCCCCCCCCCCCH		29449344
1454	Phosphorylation	GSVGNTRSSSVSRDA CCCCCCCCCCCCHHH		29449344
1455	Phosphorylation	SVGNTRSSSVSRDAF CCCCCCCCCCCHHHH		29449344
1456	Phosphorylation	VGNTRSSSVSRDAFN CCCCCCCCCCHHHHH		29449344
1458	Phosphorylation	NTRSSSVSRDAFNSA CCCCCCCCHHHHHHH		29449344
1464	Phosphorylation	VSRDAFNSAERAVTE CCHHHHHHHHHHHHH		-
1476	Phosphorylation	VTEVREVTRKSVPRN HHHHHHHHHCCCCCC		-
1479	Phosphorylation	VREVTRKSVPRNSLE HHHHHHCCCCCCCHH		24719451
1490	Phosphorylation	NSLESAEYLKLITGL CCHHHHHHHHHHHHH		24719451
1639	Phosphorylation	ADIVTELYQRKPHAT HHHHHHHHHCCCCCC		29083192
1646	Phosphorylation	YQRKPHATEQKVLVV HHCCCCCCHHHHHHH		29083192
1699	Phosphorylation	NLLNQAASQPPHIKK HHHHHHHHCCCCHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TGRM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGRM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGRM1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TGRM1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.