SC16B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC16B_HUMAN
• UniProt AC: Q96JE7
• Protein Name: Protein transport protein Sec16B
• Gene Name: SEC16B
• Organism: Homo sapiens (Human).
• Sequence Length: 1060
• Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
• Protein Description: Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization..
• Protein Sequence: MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQPHYASRPGDWHQPVSGVDYYEGGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSNSRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQADVSSAGPKAPMKFYIPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFTSTLALNDPLQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSNQAGDPELYQRAIVAIGDTLAGKGLVEAAHFCYLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLVSQALHYCEAIGAAVLSQGESSHPVLLVELIKLAEKLKLSDPLVLERRSGDRDLEPDWLAQLRRQLEQKVAGDIGDPHPTRSDISGAGGTTTENTFYQDFSGCQGYSEAPGYRSALWLTPEQTCLLQPSPQQPFPLQPGSYPAGGGAGQTGTPRPFYSVPETHLPGTGSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQPPDGQEVISKPQTPLAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGKEHTKSSGFGWFSWFRSKPTKNASPAGDEDSSDSPDSEETPRASSPHQAGLGLSLTPSPESPPLPDVSAFSRGRGGGEGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPPPALKGAVPLYNPSQVPQLPTATSLNRPNRLAQRRYPTQPC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	PQTRGKATAPSKDPD CCCCCCCCCCCCCCC	42.46	-
20	Phosphorylation	RGKATAPSKDPDRGF CCCCCCCCCCCCCCC	47.42	-
55	Phosphorylation	QWQDNRGSPQPQQEP CCCCCCCCCCCCCCC	19.68	28857561
99	Phosphorylation	GYRNQLYSRPGYENS CCCCCCCCCCCCCCC	40.36	24719451
112	Phosphorylation	NSYQSYQSPTMREEY CCCCCCCCCCHHHHH	17.69	25690035
114	Phosphorylation	YQSYQSPTMREEYAY CCCCCCCCHHHHHCC	33.82	24275569
119	Phosphorylation	SPTMREEYAYGSYYY CCCHHHHHCCCCCCC	10.60	20736484
125	Phosphorylation	EYAYGSYYYHGHPQW HHCCCCCCCCCCCHH	7.23	20736484
126	Phosphorylation	YAYGSYYYHGHPQWL HCCCCCCCCCCCHHH	7.97	20736484
143	Phosphorylation	ERVPRQRSPYIWHED CCCCCCCCCCCCCHH	17.45	27251275
145	Phosphorylation	VPRQRSPYIWHEDYR CCCCCCCCCCCHHHH	20.21	25072903
151	Phosphorylation	PYIWHEDYREQKYLD CCCCCHHHHHHHHCH	17.05	29449344
167	Phosphorylation	HHYENQHSPFGTNSE HCCCCCCCCCCCCCH	16.50	27251275
188	Phosphorylation	SRNPCKDSPASNSGQ CCCCCCCCCCCCCCC	14.09	-
191	Phosphorylation	PCKDSPASNSGQEWP CCCCCCCCCCCCCCC	34.61	-
219	Phosphorylation	KNKPSLASESNLLQQ HCCCCHHHHHHHHHH	47.02	28258704
221	Phosphorylation	KPSLASESNLLQQRE CCCHHHHHHHHHHHH	30.22	24275569
232	Phosphorylation	QQRESGLSSSSYELS HHHHHCCCCCHHHHH	31.53	25072903
233	Phosphorylation	QRESGLSSSSYELSQ HHHHCCCCCHHHHHH	28.48	29116813
234	Phosphorylation	RESGLSSSSYELSQY HHHCCCCCHHHHHHH	33.30	28258704
235	Phosphorylation	ESGLSSSSYELSQYI HHCCCCCHHHHHHHH	25.28	25072903
236	Phosphorylation	SGLSSSSYELSQYIR HCCCCCHHHHHHHHH	23.88	28348404
254	Phosphorylation	ERDDPPASAAWSPVQ CCCCCCCCCCCCCCE	25.05	27794612
258	Phosphorylation	PPASAAWSPVQADVS CCCCCCCCCCEECHH	15.51	27794612
265	Phosphorylation	SPVQADVSSAGPKAP CCCEECHHCCCCCCC	18.28	24275569
266	Phosphorylation	PVQADVSSAGPKAPM CCEECHHCCCCCCCC	36.77	24275569
450	Phosphorylation	EKFTRLLYYGRKKEA HHHHHHHHHCHHHHH	14.41	-
621	Phosphorylation	QMLGRPKSFIPSFQV HHHCCCHHHCCHHHH	30.96	23663014
625	Phosphorylation	RPKSFIPSFQVYKLL CCHHHCCHHHHHHHH	24.40	23663014
629	Phosphorylation	FIPSFQVYKLLYASR HCCHHHHHHHHHHHH	5.78	23663014
633	Phosphorylation	FQVYKLLYASRLADY HHHHHHHHHHHHHHH	16.99	23663014
635	Phosphorylation	VYKLLYASRLADYGL HHHHHHHHHHHHHCH	17.80	23663014
722	Phosphorylation	DIGDPHPTRSDISGA CCCCCCCCHHHCCCC	39.51	-
804	Phosphorylation	PFYSVPETHLPGTGS CCCCCCCCCCCCCCC	23.73	24275569
809	Phosphorylation	PETHLPGTGSSVAVT CCCCCCCCCCCEEEE	31.76	24275569
812	Phosphorylation	HLPGTGSSVAVTEAT CCCCCCCCEEEEECC	18.55	24275569
854	Phosphorylation	PDGQEVISKPQTPLA CCCCCCCCCCCCCCC	43.38	24275569
858	Phosphorylation	EVISKPQTPLAARPR CCCCCCCCCCCCCCC	28.88	24275569
866	Phosphorylation	PLAARPRSISESSAS CCCCCCCCCCHHHHH	32.90	25072903
868	Phosphorylation	AARPRSISESSASSA CCCCCCCCHHHHHCC	32.45	25072903
870	Phosphorylation	RPRSISESSASSAKE CCCCCCHHHHHCCCH	25.14	25072903
871	Phosphorylation	PRSISESSASSAKED CCCCCHHHHHCCCHH	28.28	-
874	Phosphorylation	ISESSASSAKEDEKE CCHHHHHCCCHHHHH	42.97	-
882	Phosphorylation	AKEDEKESSDEADKN CCHHHHHCCCHHHHC	54.91	23090842
883	Phosphorylation	KEDEKESSDEADKNS CHHHHHCCCHHHHCC	40.33	23090842
890	Phosphorylation	SDEADKNSPRNTAQR CCHHHHCCCCCHHHC	30.86	23090842
894	Phosphorylation	DKNSPRNTAQRGKLG HHCCCCCHHHCCCCC	26.00	23090842
927	Phosphorylation	SKPTKNASPAGDEDS CCCCCCCCCCCCCCC	25.36	25072903
934	Phosphorylation	SPAGDEDSSDSPDSE CCCCCCCCCCCCCCC	33.72	22798277
935	Phosphorylation	PAGDEDSSDSPDSEE CCCCCCCCCCCCCCC	55.20	22798277
937	Phosphorylation	GDEDSSDSPDSEETP CCCCCCCCCCCCCCC	32.33	25072903
940	Phosphorylation	DSSDSPDSEETPRAS CCCCCCCCCCCCCCC	40.49	25072903
943	Phosphorylation	DSPDSEETPRASSPH CCCCCCCCCCCCCCC	17.64	25072903
947	Phosphorylation	SEETPRASSPHQAGL CCCCCCCCCCCCCCC	45.76	26657352
948	Phosphorylation	EETPRASSPHQAGLG CCCCCCCCCCCCCCC	25.97	28450419
957	Phosphorylation	HQAGLGLSLTPSPES CCCCCCCCCCCCCCC	28.53	28450419
959	Phosphorylation	AGLGLSLTPSPESPP CCCCCCCCCCCCCCC	20.53	28450419
961	Phosphorylation	LGLSLTPSPESPPLP CCCCCCCCCCCCCCC	35.74	25072903
964	Phosphorylation	SLTPSPESPPLPDVS CCCCCCCCCCCCCCC	34.89	25072903
974	Phosphorylation	LPDVSAFSRGRGGGE CCCCCCCCCCCCCCC	33.28	26503514
988	Phosphorylation	EGRGSASSGGAAAGA CCCCCCCCCCCCCCC	40.75	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC16B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC16B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC16B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POTEF_HUMAN	POTEF	physical	28514442
SEC13_HUMAN	SEC13	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.