| UniProt ID | MCLN3_HUMAN | |
|---|---|---|
| UniProt AC | Q8TDD5 | |
| Protein Name | Mucolipin-3 {ECO:0000303|PubMed:19497048} | |
| Gene Name | MCOLN3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 553 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Early endosome membrane Multi-pass membrane protein . Late endosome membrane Multi-pass membrane protein . Lysosome membrane Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome membrane . No |
|
| Protein Description | Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. [PubMed: 18369318] | |
| Protein Sequence | MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | DPEVVVSSCSSHEEE CCEEEEECCCCHHHH | 13.35 | 25850435 | |
| 12 | Phosphorylation | EVVVSSCSSHEEENR EEEEECCCCHHHHCC | 36.36 | 26471730 | |
| 13 | Phosphorylation | VVVSSCSSHEEENRC EEEECCCCHHHHCCC | 38.97 | 25850435 | |
| 26 | Phosphorylation | RCNFNQQTSPSEELL CCCCCCCCCCCHHHH | 32.61 | 29759185 | |
| 27 | Phosphorylation | CNFNQQTSPSEELLL CCCCCCCCCCHHHHH | 23.30 | 29759185 | |
| 59 | Acetylation | KFWARGRKPWKLAIQ HHHHCCCCHHHHHHH | 59.04 | 70979 | |
| 68 | Ubiquitination | WKLAIQILKIAMVTI HHHHHHHHHHHHHHH | 1.56 | 27667366 | |
| 69 | Acetylation | KLAIQILKIAMVTIQ HHHHHHHHHHHHHHH | 30.01 | 70983 | |
| 74 | Phosphorylation | ILKIAMVTIQLVLFG HHHHHHHHHHHHHHC | 7.02 | - | |
| 83 | Phosphorylation | QLVLFGLSNQMVVAF HHHHHCCCCCEEEEE | 25.95 | - | |
| 138 | N-linked_Glycosylation | NQYLQLYNVSVGNHA HHHHHHCCCCCCCCC | 28.34 | 29106414 | |
| 167 | Ubiquitination | QHFYKRGNIYPGNDT HHHHHHCCCCCCCCC | 34.35 | 27667366 | |
| 172 | N-linked_Glycosylation | RGNIYPGNDTFDIDP HCCCCCCCCCCCCCC | 40.42 | 29106414 | |
| 191 | Ubiquitination | ECFFVEPDEPFHIGT EEEEECCCCCCCCCC | 63.80 | 27667366 | |
| 205 | N-linked_Glycosylation | TPAENKLNLTLDFHR CCCCCCCCEEEEHHH | 32.37 | - | |
| 207 | Phosphorylation | AENKLNLTLDFHRLL CCCCCCEEEEHHHHH | 24.17 | 22210691 | |
| 223 | Ubiquitination | VELQFKLKAINLQTV HHHHHHHEECCCCCC | 48.05 | 27667366 | |
| 236 | Ubiquitination | TVRHQELPDCYDFTL CCCCCCCCCCEEEEE | 28.95 | 27667366 | |
| 247 | Ubiquitination | DFTLTITFDNKAHSG EEEEEEEECCCCCCC | 9.59 | 27667366 | |
| 265 | Phosphorylation | ISLDNDISIRECKDW EEECCCCCCEECCCC | 20.61 | 24719451 | |
| 284 | Phosphorylation | SIQKNTHYMMIFDAF CCCCCCCHHHHHHHH | 6.07 | 20049867 | |
| 295 | Phosphorylation | FDAFVILTCLVSLIL HHHHHHHHHHHHHHH | 7.83 | 20049867 | |
| 356 | Phosphorylation | DILTIIGSILKMEIQ HHHHHHHHHHHHHHH | 17.84 | 24719451 | |
| 381 | Ubiquitination | SILLGTSTMLVWLGV HHHHCHHHHHHHHHH | 17.86 | 21890473 | |
| 473 | Ubiquitination | KMQQKSYLVWLFSRI HHHHHHHHHHHHHHH | 2.62 | 33845483 | |
| 480 | Ubiquitination | LVWLFSRIYLYSFIS HHHHHHHHHHHHHHH | 2.42 | 21890473 | |
| 480 (in isoform 2) | Ubiquitination | - | 2.42 | 21890473 | |
| 504 | Ubiquitination | FIALITDTYETIKQY HHHHHHCHHHHHHHH | 18.01 | 21890473 | |
| 529 | Ubiquitination | RTFISECKDLPNSGK HHHHHHHCCCCCCCC | 59.24 | 33845483 | |
| 534 | Phosphorylation | ECKDLPNSGKYRLED HHCCCCCCCCCCCCC | 34.42 | 22468782 | |
| 536 | Ubiquitination | KDLPNSGKYRLEDDP CCCCCCCCCCCCCCC | 27.33 | 22817900 | |
| 536 (in isoform 1) | Ubiquitination | - | 27.33 | 21890473 | |
| 546 | Phosphorylation | LEDDPPVSLFCCCKK CCCCCCEEEEEEEEC | 22.85 | 22468782 | |
| 549 | S-palmitoylation | DPPVSLFCCCKK--- CCCEEEEEEEEC--- | 3.02 | 30215288 | |
| 549 | Ubiquitination | DPPVSLFCCCKK--- CCCEEEEEEEEC--- | 3.02 | 21890473 | |
| 550 | S-palmitoylation | PPVSLFCCCKK---- CCEEEEEEEEC---- | 2.74 | 30215288 | |
| 551 | S-palmitoylation | PVSLFCCCKK----- CEEEEEEEEC----- | 7.10 | 30215288 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MCLN3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MCLN3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MCLN3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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