| UniProt ID | GBRB3_HUMAN | |
|---|---|---|
| UniProt AC | P28472 | |
| Protein Name | Gamma-aminobutyric acid receptor subunit beta-3 | |
| Gene Name | GABRB3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 473 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein . Cell membrane Multi-pass membrane protein . Cytoplasmic vesicle membrane . |
|
| Protein Description | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.. | |
| Protein Sequence | MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | N-linked_Glycosylation | QSVNDPGNMSFVKET HCCCCCCCCHHHHHH | 28.45 | 24909990 | |
| 35 (in isoform 2) | Phosphorylation | - | 30.78 | - | |
| 35 | Phosphorylation | VNDPGNMSFVKETVD CCCCCCCHHHHHHHH | 30.78 | - | |
| 40 (in isoform 2) | Phosphorylation | - | 28.43 | - | |
| 40 | Phosphorylation | NMSFVKETVDKLLKG CCHHHHHHHHHHHCC | 28.43 | - | |
| 43 | Ubiquitination | FVKETVDKLLKGYDI HHHHHHHHHHCCCCE | 51.92 | - | |
| 46 | Ubiquitination | ETVDKLLKGYDIRLR HHHHHHHCCCCEECC | 66.90 | - | |
| 105 | N-linked_Glycosylation | AYSGIPLNLTLDNRV CCCCCCCEEEECCCH | 26.14 | 24909990 | |
| 127 | Ubiquitination | DTYFLNDKKSFVHGV CEEECCCCCCEEEEE | 49.60 | - | |
| 128 | Ubiquitination | TYFLNDKKSFVHGVT EEECCCCCCEEEEEE | 52.57 | - | |
| 137 | Ubiquitination | FVHGVTVKNRMIRLH EEEEEEECCCEEEEC | 29.48 | - | |
| 158 | Phosphorylation | YGLRITTTAACMMDL EEEEEEHHHHHHHHH | 12.01 | 24260401 | |
| 174 | N-linked_Glycosylation | RYPLDEQNCTLEIES CCCCCCCCCEEEEEE | 20.77 | 24909990 | |
| 198 | Ubiquitination | FYWRGGDKAVTGVER EEECCCCCCCCCEEE | 48.29 | - | |
| 236 | Phosphorylation | AYPRLSLSFRLKRNI CCCCEEEEEEEHHHH | 12.63 | 24719451 | |
| 309 | Phosphorylation | YVKAIDMYLMGCFVF HHHHHHHHHHHHHHH | 6.98 | - | |
| 324 | Phosphorylation | VFLALLEYAFVNYIF HHHHHHHHHHHHHHH | 12.81 | - | |
| 432 | Phosphorylation | KTHLRRRSSQLKIKI HHHHHHHHHCCEEEC | 22.18 | 20940303 | |
| 433 | Phosphorylation | THLRRRSSQLKIKIP HHHHHHHHCCEEECC | 37.41 | 20940303 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBRB3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBRB3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBRB3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AKAP5_HUMAN | AKAP5 | physical | 12595241 | |
| KPCA_HUMAN | PRKCA | physical | 12595241 | |
| KAPCA_HUMAN | PRKACA | physical | 12595241 | |
| MEOX2_HUMAN | MEOX2 | physical | 24722188 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 612269 | Epilepsy, childhood absence 5 (ECA5) | |||||
| Kegg Drug | ||||||
| D00058 | Gamma-Aminobutyric acid (JAN); Gammalon (TN) | |||||
| D00225 | Alprazolam (JP16/USP/INN); Xanax (TN) | |||||
| D00267 | Chlordiazepoxide (JP16/USP/INN); Libritabs (TN) | |||||
| D00280 | Clonazepam (JP16/USP/INN); Klonopin (TN) | |||||
| D00293 | Diazepam (JP16/USP/INN); Diastat (TN); Valium (TN) | |||||
| D00311 | Estazolam (JP16/USAN/INN); ProSom (TN) | |||||
| D00329 | Flurazepam (JAN/INN); Insumin (TN) | |||||
| D00365 | Lorazepam (JP16/USP/INN); Ativan (TN) | |||||
| D00370 | Temazepam (USP/INN); Restoril (TN) | |||||
| D00376 | Meprobamate (JAN/USP/INN); Equanil (TN); Miltown (TN) | |||||
| D00387 | Triazolam (JAN/USP/INN); Halcion (TN) | |||||
| D00430 | Secobarbital (USP/INN); Seconal (TN) | |||||
| D00457 | Quazepam (JAN/USP/INN); Doral (TN) | |||||
| D00470 | Prazepam (JP16/USAN/INN); Centrax (TN) | |||||
| D00499 | Pentobarbital (USP/INN); Nembutal (TN) | |||||
| D00500 | Pentobarbital sodium (JAN/USP); Nembutal sodium (TN) | |||||
| D00506 | Phenobarbital (JP16/USP/INN); Luminal (TN) | |||||
| D00531 | Nitrazepam (JP16/USAN/INN); Benzalin (TN); Nitrazepam (TN) | |||||
| D00532 | Glutethimide (JAN/INN); Doriden (TN) | |||||
| D00549 | Propofol (JAN/USAN/INN); Diprivan (TN) | |||||
| D00550 | Midazolam (JAN/USP/INN); Dormicum (TN); Buccolam (TN) | |||||
| D00555 | Amobarbital (JP16/INN); Isomytal (TN) | |||||
| D00557 | Methaqualone (JAN/USAN/INN) | |||||
| D00693 | Chlordiazepoxide hydrochloride (JAN/USP); Librium (TN) | |||||
| D00694 | Clorazepate dipotassium (JP16/USP); Tranxene (TN) | |||||
| D00695 | Flurazepam hydrochloride (USP); Flurazepam dihydrochloride; Dalmane (TN) | |||||
| D00696 | Midazolam hydrochloride (USAN); Versed (TN) | |||||
| D00697 | Flumazenil (JAN/USP/INN); Romazicon (TN) | |||||
| D00700 | Mephobarbital (JAN/USP); Methylphenobarbital (INN); Mebaral (TN) | |||||
| D00701 | Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN) | |||||
| D00706 | Zolpidem tartrate (JP16/USAN); Ambien (TN); Intermezzo (TN) | |||||
| D00713 | Thiamylal sodium (JP16); Surital (TN) | |||||
| D00714 | Thiopental sodium (JP16/USP/INN); Pentothal (TN) | |||||
| D01071 | Hexobarbital (JAN/INN) | |||||
| D01230 | Flunitrazepam (JP16/USAN/INN); Rohypnol (TN) | |||||
| D01245 | Bromazepam (JP16/USAN/INN); Lectopam (TN) | |||||
| D01253 | Clobazam (JAN/USAN/INN); Mystan (TN); Onfi (TN) | |||||
| D01254 | Tofisopam (JP16/INN); Emandaxin (TN) | |||||
| D01268 | Cloxazolam (JP16/INN); Sepazon (TN) | |||||
| D01278 | Oxazolam (JP16/INN); Serenal (TN) | |||||
| D01279 | Flutoprazepam (JP16/INN); Restas (TN) | |||||
| D01286 | Flutazolam (JAN/INN); Coreminal (TN) | |||||
| D01292 | Medazepam (JP16/INN); Pamnace (TN) | |||||
| D01293 | Ethyl loflazepate (JAN/INN); Meilax (TN) | |||||
| D01310 | Secobarbital sodium (JAN/USP); Seconal sodium (TN) | |||||
| D01316 | Mexazolam (JAN/INN); Melex (TN) | |||||
| D01328 | Clotiazepam (JP16/INN); Rize (TN) | |||||
| D01354 | Fludiazepam (JP16/INN); Erispan (TN) | |||||
| D01372 | Zopiclone (JAN/INN); Amoban (TN); Zopiclone (TN) | |||||
| D01408 | Flurazepam hydrochloride (JP16); Flurazepam monohydrochloride; Dalmate (TN) | |||||
| D01514 | Etizolam (JP16/INN); Sedekopan (TN) | |||||
| D01564 | Rilmazafone hydrochloride hydrate (JAN); Rilmazafone hydrochloride dihydrate; Rilmazafone hydrochlor | |||||
| D01593 | Nimetazepam (JAN/INN); Erimin (TN) | |||||
| D01657 | Lormetazepam (JAN/USAN/INN); Loramet (TN) | |||||
| D01740 | Barbital (JP16/INN); Barbital (TN) | |||||
| D01744 | Brotizolam (JP16/USAN/INN); Lendormin (TN) | |||||
| D01758 | Haloxazolam (JP16/INN); Somelin (TN) | |||||
| D02252 | Amobarbital sodium (JAN/USP); Amytal sodium (TN) | |||||
| D02253 | Pentobarbital calcium (JP16); Ravona (TN) | |||||
| D02283 | Iomazenil (123I) (JAN/INN); Benzodine (TN) | |||||
| D02594 | Abecarnil (INN) | |||||
| D02616 | Pagoclone (USAN/INN); Bextra (TN) | |||||
| D02617 | Ocinaplon (USAN/INN) | |||||
| D02624 | Eszopiclone (JAN/USAN/INN); Estorra (TN); Lunesta (TN) | |||||
| D02833 | Alpidem (USAN/INN) | |||||
| D03155 | Bretazenil (USAN/INN) | |||||
| D03562 | Clorazepate monopotassium (USAN) | |||||
| D03737 | Dextofisopam (USAN/INN) | |||||
| D04257 | Fospropofol disodium (USAN); Aquavan (TN); Lusedra (TN) | |||||
| D04282 | Gaboxadol (USAN/INN) | |||||
| D04300 | Ganaxolone (USAN/INN) | |||||
| D04721 | Levotofisopam (USAN/INN) | |||||
| D04882 | Medazepam hydrochloride (USAN); Nobrium (TN) | |||||
| D05028 | Midazolam maleate (USAN) | |||||
| D06106 | Thiamylal | |||||
| D07326 | Loprazolam (INN); Dormonoct (TN) | |||||
| D07409 | Pentetrazol (INN); Pentylenetetrazol; Coryvet [veterinary] (TN) | |||||
| D07784 | Delorazepam (INN); Dadumir (TN) | |||||
| D08145 | Loprazolam mesilate; Loprazolam mesylate; Loprazolam methanesulfonate; Havlane (TN) | |||||
| D08283 | Nordazepam (INN); Calmday (TN) | |||||
| D08356 | Phenobarbital diethylamine; Gratusminal (TN) | |||||
| D08481 | Rilmazafone (INN) | |||||
| D08507 | Sarmazenil (INN); Sarmazol [veterinary] (TN) | |||||
| D08690 | Zolpidem (INN); Sanval (TN) | |||||
| D08840 | Adipiplon (USAN) | |||||
| D10194 | Remimazolam besilate (JAN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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