| UniProt ID | MCLN2_HUMAN | |
|---|---|---|
| UniProt AC | Q8IZK6 | |
| Protein Name | Mucolipin-2 | |
| Gene Name | MCOLN2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 566 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Late endosome membrane Multi-pass membrane protein . Lysosome membrane Multi-pass membrane protein . Recycling endosome membrane Multi-pass membrane protein . Localizes to recycling endosomes in act |
|
| Protein Description | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. [PubMed: 19940139] | |
| Protein Sequence | MARQPYRFPQARIPERGSGVFRLTVRNAMAHRDSEMKEECLREDLKFYFMSPCEKYRARRQIPWKLGLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGYSGTDEDDYSCSVYTQEDAYESIFFAINQYHQLKDITLGTLGYGENEDNRIGLKVCKQHYKKGTMFPSNETLNIDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYRLLQVEISFHLKGIDLQTIHSRELPDCYVFQNTIIFDNKAHSGKIKIYFDSDAKIEECKDLNIFGSTQKNAQYVLVFDAFVIVICLASLILCTRSIVLALRLRKRFLNFFLEKYKRPVCDTDQWEFINGWYVLVIISDLMTIIGSILKMEIKAKNLTNYDLCSIFLGTSTLLVWVGVIRYLGYFQAYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHDKFENLNTVAECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKFQQNGFPETDLQEFLKECSSKEEYQKESSAFLSCICCRRRKRSDDHLIPIS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MARQPYRFPQARI --CCCCCCCCCCCCC | 19.29 | 24719451 | |
| 9 | Ubiquitination | ARQPYRFPQARIPER CCCCCCCCCCCCCCC | 20.23 | 29901268 | |
| 18 | Phosphorylation | ARIPERGSGVFRLTV CCCCCCCCCEEEEHH | 37.70 | 28348404 | |
| 37 | Ubiquitination | AHRDSEMKEECLRED HCCCHHHHHHHHHHH | 46.43 | 29901268 | |
| 209 | Phosphorylation | PPDWKNSSFFRLEFY CCCCCCCCCCHHHHH | 37.49 | 24719451 | |
| 361 | Phosphorylation | DLMTIIGSILKMEIK HHHHHHHHHHHHHHH | 17.84 | 24719451 | |
| 508 | Ubiquitination | LFIALITDSYDTIKK HHHHHHCCCHHHHHH | 37.90 | 33845483 | |
| 536 | Ubiquitination | FLKECSSKEEYQKES HHHHHCCHHHHHHHH | 37.97 | 33845483 | |
| 558 | Phosphorylation | CCRRRKRSDDHLIPI HHCCCCCCCCCCCCC | 50.88 | 24719451 | |
| 558 | Phosphorylation | CCRRRKRSDDHLIPI HHCCCCCCCCCCCCC | 50.88 | 29255136 | |
| 566 | Phosphorylation | DDHLIPIS------- CCCCCCCC------- | 28.90 | 26307563 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MCLN2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MCLN2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MCLN2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MCLN2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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