PXYP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PXYP1_HUMAN
• UniProt AC: Q8TE99
• Protein Name: 2-phosphoxylose phosphatase 1 {ECO:0000303|PubMed:24425863}
• Gene Name: PXYLP1 {ECO:0000312|HGNC:HGNC:26303}
• Organism: Homo sapiens (Human).
• Sequence Length: 480
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein . Colocalizes to Golgi apparatus in a B3GAT3-dependent manner.
• Protein Description: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains..
• Protein Sequence: MLFRNRFLLLLALAALLAFVSLSLQFFHLIPVSTPKNGMSSKSRKRIMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEAFISHMSKGSGASFESPLNSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLCHFCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERERREKKLYFGYSLLGAHPILNQTIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDREKPSEHSVRILYNGVDVTFHTSFCQDHHKRSPKPMCPLENLVRFVKRDMFVALGGSGTNYYDACHREGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	O-linked_Glycosylation	RIMPDPVTEPPVTDP CCCCCCCCCCCCCCH		OGP
58	O-linked_Glycosylation	PVTEPPVTDPVYEAL CCCCCCCCCHHHHHH		OGP
101	Phosphorylation	FIRHGDRYPLYVIPK EEECCCCCEEEEECC		-
104	Phosphorylation	HGDRYPLYVIPKTKR CCCCCEEEEECCCCC		-
110	Ubiquitination	LYVIPKTKRPEIDCT EEEECCCCCCCCCEE		-
117	Phosphorylation	KRPEIDCTLVANRKP CCCCCCEEEEECCCC		24719451
134	Phosphorylation	PKLEAFISHMSKGSG HHHHHHHHHHHCCCC		26657352
189	Ubiquitination	DIYLKKHKLLPNDWS HHHHHHCCCCCCCCC		-
207	Ubiquitination	LYLETTGKSRTLQSG EEECCCCCCCCHHHH		-
244	Phosphorylation	SALFCSGSCYCPVRN CEEEECCCCCCCCHH		30631047
256	Ubiquitination	VRNQYLEKEQRRQYL CHHHHCCHHHHHHHH		-
267	Ubiquitination	RQYLLRLKNSQLEKT HHHHHHHHHHHHHHH		-
287	Ubiquitination	KIVDVPTKQLRAANP HHCCCCHHHHHHCCC		-
305	N-linked_Glycosylation	MLCHFCHNVSFPCTR HHHHHHCCCCCCCCC		UniProtKB CARBOHYD
325	Ubiquitination	MEHFKVIKTHQIEDE HHHEEEEEECCCCCH		-
354	N-linked_Glycosylation	LGAHPILNQTIGRMQ HCCCHHHHHHHHHHH		UniProtKB CARBOHYD
375	Phosphorylation	KEELFALYSAHDVTL HHHHHHHHHHCCCCH		26552605
376	Phosphorylation	EELFALYSAHDVTLS HHHHHHHHHCCCCHH		26552605
381	Phosphorylation	LYSAHDVTLSPVLSA HHHHCCCCHHHHHHH		26552605
383	Phosphorylation	SAHDVTLSPVLSALG HHCCCCHHHHHHHHC		26552605
387	Phosphorylation	VTLSPVLSALGLSEA CCHHHHHHHHCCCHH		26552605
392	Phosphorylation	VLSALGLSEARFPRF HHHHHCCCHHCCHHH		26552605
444	Ubiquitination	DHHKRSPKPMCPLEN HHCCCCCCCCCCHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PXYP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PXYP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PXYP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADCY9_HUMAN	ADCY9	physical	28514442
FURIN_HUMAN	FURIN	physical	28514442
GNPTA_HUMAN	GNPTAB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.