SEM4C_HUMAN - dbPTM
SEM4C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEM4C_HUMAN
UniProt AC Q9C0C4
Protein Name Semaphorin-4C
Gene Name SEMA4C
Organism Homo sapiens (Human).
Sequence Length 833
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Single-pass type I membrane protein.
Protein Description Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade..
Protein Sequence MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPFRPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34PhosphorylationLVPRKTVSSGELATV
CCCCCCCCHHHHHHH		37.5522210691
55PhosphorylationTGIQDFLTLTLTEPT
CCCCCEEEEEECCCC		20.0726074081
57PhosphorylationIQDFLTLTLTEPTGL
CCCEEEEEECCCCCE		26.8026074081
59PhosphorylationDFLTLTLTEPTGLLY
CEEEEEECCCCCEEE		34.3826074081
62PhosphorylationTLTLTEPTGLLYVGA
EEEECCCCCEEEEEH		33.9426074081
106N-linked_GlycosylationCIQKGKNNQTECFNF
HHHCCCCCCHHHHHH		54.35UniProtKB CARBOHYD
121N-linked_GlycosylationIRFLQPYNASHLYVC
HHHHCCCCCCCEEEE		41.47UniProtKB CARBOHYD
249PhosphorylationRAVESDCYAEQVVAR
CCCCCCCHHHHHHHH		20.40-
254UbiquitinationDCYAEQVVARVARVC
CCHHHHHHHHHHHHC		2.5523503661
255UbiquitinationCYAEQVVARVARVCK
CHHHHHHHHHHHHCC		11.0223503661
310N-linked_GlycosylationLQDTSWHNTTFFGVF
CCCCCCCCCCEEEEE		34.26UniProtKB CARBOHYD
341UbiquitinationLEEIQRVFEGPYKEY
HHHHHHHHCCCHHHH		11.0727667366
348PhosphorylationFEGPYKEYHEEAQKW
HCCCHHHHHHHHHHH		15.4730266825
395UbiquitinationDNILNFVKKHPLMEE
HHHHHHHHHCCCHHC		41.0223503661
396UbiquitinationNILNFVKKHPLMEEQ
HHHHHHHHCCCHHCC		45.1923503661
419N-linked_GlycosylationLLVKKGTNFTHLVAD
EEEECCCCCHHHEEH		48.79UniProtKB CARBOHYD
437UbiquitinationGLDGATYTVLFIGTG
CCCCCEEEEEEEECC		13.3323503661
438UbiquitinationLDGATYTVLFIGTGD
CCCCEEEEEEEECCC		2.6423503661
481UbiquitinationSLVLSQSKKLLFAGS
HHHHHHCCEEEECCC		39.5429967540
482UbiquitinationLVLSQSKKLLFAGSR
HHHHHCCEEEECCCH		56.5227667366
488PhosphorylationKKLLFAGSRSQLVQL
CEEEECCCHHHCEEC		25.9029523821
522N-linked_GlycosylationPYCAWSVNTSRCVAV
CCEEEEEECCCCEEE		27.16UniProtKB CARBOHYD
524UbiquitinationCAWSVNTSRCVAVGG
EEEEEECCCCEEECC		20.6227667366
564N-linked_GlycosylationKVRPTPKNITVVAGT
CCCCCCCCEEEEECC		36.05UniProtKB CARBOHYD
603UbiquitinationPAEQPGSFLYDARLQ
CCCCCCCCHHHHHHH		10.1821890473
699UbiquitinationEELEKGAKATERTLV
HHHHHHCCCCCCEEE		65.5932142685
704PhosphorylationGAKATERTLVYPLEL
HCCCCCCEEEEECCC		17.84-
707PhosphorylationATERTLVYPLELPKE
CCCCEEEEECCCCCC		12.7625884760
713UbiquitinationVYPLELPKEPTSPPF
EEECCCCCCCCCCCC		84.6029967540
716PhosphorylationLELPKEPTSPPFRPC
CCCCCCCCCCCCCCC		55.7630266825
717PhosphorylationELPKEPTSPPFRPCP
CCCCCCCCCCCCCCC		41.0930266825
729UbiquitinationPCPEPDEKLWDPVGY
CCCCCCCCCCCCCEE		63.3632015554
736PhosphorylationKLWDPVGYYYSDGSL
CCCCCCEEEECCCCE		10.2425884760
737PhosphorylationLWDPVGYYYSDGSLK
CCCCCEEEECCCCEE		7.2025884760
738PhosphorylationWDPVGYYYSDGSLKI
CCCCEEEECCCCEEE		7.5723186163
739PhosphorylationDPVGYYYSDGSLKIV
CCCEEEECCCCEEEE		21.2625159151
742PhosphorylationGYYYSDGSLKIVPGH
EEEECCCCEEEECCC		31.3228450419
744UbiquitinationYYSDGSLKIVPGHAR
EECCCCEEEECCCCC		43.2722817900
760PhosphorylationQPGGGPPSPPPGIPG
CCCCCCCCCCCCCCC		53.8529255136
772PhosphorylationIPGQPLPSPTRLHLG
CCCCCCCCCCEEEEC		46.7329255136
774PhosphorylationGQPLPSPTRLHLGGG
CCCCCCCCEEEECCC		50.6429255136
784PhosphorylationHLGGGRNSNANGYVR
EECCCCCCCCCCEEE		35.6423898821
786UbiquitinationGGGRNSNANGYVRLQ
CCCCCCCCCCEEEEE		15.6221890473
789PhosphorylationRNSNANGYVRLQLGG
CCCCCCCEEEEEECC		5.1228152594
831PhosphorylationPDSNPEESSV-----
CCCCCCCCCC-----		34.4429514088
832PhosphorylationDSNPEESSV------
CCCCCCCCC------		34.8223403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEM4C_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEM4C_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEM4C_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DLG4_HUMANDLG4physical
11134026
DLG3_HUMANDLG3physical
11134026
DLG2_HUMANDLG2physical
11134026
K1C40_HUMANKRT40physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEM4C_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832, AND MASSSPECTROMETRY.

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