TAF7L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF7L_HUMAN
• UniProt AC: Q5H9L4
• Protein Name: Transcription initiation factor TFIID subunit 7-like
• Gene Name: TAF7L
• Organism: Homo sapiens (Human).
• Sequence Length: 462
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids..
• Protein Description: Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity)..
• Protein Sequence: MECPEGQLPISSENDSTPTVSTSEVTSQQEPQILVDRGSETTYESSADIAGDEGTQIPADEDTQTDADSSAQAAAQAPENFQEGKDMSESQDEVPDEVENQFILRLPLEHACTVRNLARSQSVKMKDKLKIDLLPDGRHAVVEVEDVPLAAKLVDLPCVIESLRTLDKKTFYKTADISQMLVCTADGDIHLSPEEPAASTDPNIVRKKERGREEKCVWKHGITPPLKNVRKKRFRKTQKKVPDVKEMEKSSFTEYIESPDVENEVKRLLRSDAEAVSTRWEVIAEDGTKEIESQGSIPGFLISSGMSSHKQGHTSSEYDMLREMFSDSRSNNDDDEDEDDEDEDEDEDEDEDEDKEEEEEDCSEEYLERQLQAEFIESGQYRANEGTSSIVMEIQKQIEKKEKKLHKIQNKAQRQKDLIMKVENLTLKNHFQSVLEQLELQEKQKNEKLISLQEQLQRFLKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Phosphorylation	RNLARSQSVKMKDKL HHHHHCCCCCCCCCE	25.59	24505115
184	Phosphorylation	ISQMLVCTADGDIHL HHHEEEEECCCCEEC	21.94	21712546
223	Phosphorylation	CVWKHGITPPLKNVR CHHHCCCCCCHHHHH	24.36	21712546
228 (in isoform 3)	Phosphorylation	-	46.65	24043423
229 (in isoform 3)	Phosphorylation	-	10.17	24043423
230 (in isoform 3)	Phosphorylation	-	48.44	24043423
251	Phosphorylation	VKEMEKSSFTEYIES HHHHHHHCHHHHHCC	47.45	28555341
258	Phosphorylation	SFTEYIESPDVENEV CHHHHHCCCCHHHHH	19.49	21712546
307	Phosphorylation	FLISSGMSSHKQGHT EEECCCCCCCCCCCC	32.58	28555341
314	Phosphorylation	SSHKQGHTSSEYDML CCCCCCCCCHHHHHH	40.55	22210691
315	Phosphorylation	SHKQGHTSSEYDMLR CCCCCCCCHHHHHHH	18.59	22210691
426	Phosphorylation	IMKVENLTLKNHFQS HHHHHHHHHHHHHHH	47.47	26074081
433	Phosphorylation	TLKNHFQSVLEQLEL HHHHHHHHHHHHHHH	27.94	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF7L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF7L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF7L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAF1_HUMAN	TAF1	physical	12665565
A4_HUMAN	APP	physical	21832049
TAF1_HUMAN	TAF1	physical	28514442
TAF3_HUMAN	TAF3	physical	28514442
TAF9B_HUMAN	TAF9B	physical	28514442
TAF2_HUMAN	TAF2	physical	28514442
TAF11_HUMAN	TAF11	physical	28514442
TAF6_HUMAN	TAF6	physical	28514442
TAF5_HUMAN	TAF5	physical	28514442
TAF4B_HUMAN	TAF4B	physical	28514442
TAF9_HUMAN	TAF9	physical	28514442
TAF8_HUMAN	TAF8	physical	28514442
TAF4_HUMAN	TAF4	physical	28514442
TAF12_HUMAN	TAF12	physical	28514442
TAF13_HUMAN	TAF13	physical	28514442
TAF10_HUMAN	TAF10	physical	28514442
UTP6_HUMAN	UTP6	physical	28514442
PSME4_HUMAN	PSME4	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.