TAF4B_HUMAN - dbPTM
TAF4B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAF4B_HUMAN
UniProt AC Q92750
Protein Name Transcription initiation factor TFIID subunit 4B
Gene Name TAF4B
Organism Homo sapiens (Human).
Sequence Length 862
Subcellular Localization Nucleus . Cytoplasm . Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
Protein Description Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis..
Protein Sequence MPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSPVGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGTVLIKSNSGPLMLVSPQQTVTRAETTSNITSRPAVPANPQTVKICTVPNSSSQLIKKVAVTPVKKLAQIGTTVVTTVPKPSSVQSVAVPTSVVTVTPGKPLNTVTTLKPSSLGASSTPSNEPNLKAENSAAVQINLSPTMLENVKKCKNFLAMLIKLACSGSQSPEMGQNVKKLVEQLLDAKIEAEEFTRKLYVELKSSPQPHLVPFLKKSVVALRQLLPNSQSFIQQCVQQTSSDMVIATCTTTVTTSPVVTTTVSSSQSEKSIIVSGATAPRTVSVQTLNPLAGPVGAKAGVVTLHSVGPTAATGGTTAGTGLLQTSKPLVTSVANTVTTVSLQPEKPVVSGTAVTLSLPAVTFGETSGAAICLPSVKPVVSSAGTTSDKPVIGTPVQIKLAQPGPVLSQPAGIPQAVQVKQLVVQQPSGGNEKQVTTISHSSTLTIQKCGQKTMPVNTIIPTSQFPPASILKQITLPGNKILSLQASPTQKNRIKENVTSCFRDEDDINDVTSMAGVNLNEENACILATNSELVGTLIQSCKDEPFLFIGALQKRILDIGKKHDITELNSDAVNLISQATQERLRGLLEKLTAIAQHRMTTYKASENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKELQQLELAQIQHRDANLTALAAIGPRKKRPLESGIEGLKDNLLASGTSSLTATKQLHRPRITRICLRDLIFCMEQEREMKYSRALYLALLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationAAPPAAVSASGTVTM
CCCCCEECCCCEEEE		16.4024719451
22PhosphorylationAAVSASGTVTMAPAG
CEECCCCEEEECCCC		15.4224719451
46O-linked_GlycosylationPVALGAVTKAPVSVC
CEEECCCCCCCEEEE		22.4330059200
57PhosphorylationVSVCVEPTASQPLRS
EEEEECCCCCCCCCC		25.9928450419
59PhosphorylationVCVEPTASQPLRSPV
EEECCCCCCCCCCCC		34.5128450419
63MethylationPTASQPLRSPVGTLV
CCCCCCCCCCCCEEE		45.67115918121
64PhosphorylationTASQPLRSPVGTLVT
CCCCCCCCCCCEEEE		31.4628450419
68PhosphorylationPLRSPVGTLVTKVAP
CCCCCCCEEEEEEEC		20.4928450419
71PhosphorylationSPVGTLVTKVAPVSA
CCCCEEEEEEECCCC		23.9428450419
87MethylationPKVSSGPRLPAPQIV
CCCCCCCCCCCCEEE		57.75115918125
116PhosphorylationNLQLPPGTVLIKSNS
CCCCCCCCEEEECCC		20.2228060719
176PhosphorylationLIKKVAVTPVKKLAQ
HHHHHCCCCHHHHHC		16.7821815630
179AcetylationKVAVTPVKKLAQIGT
HHCCCCHHHHHCCCC		43.1825953088
230PhosphorylationKPSSLGASSTPSNEP
CHHHCCCCCCCCCCC		32.7125627689
231PhosphorylationPSSLGASSTPSNEPN
HHHCCCCCCCCCCCC		43.7525627689
232PhosphorylationSSLGASSTPSNEPNL
HHCCCCCCCCCCCCC		28.3925627689
252PhosphorylationAAVQINLSPTMLENV
EEEEEECCHHHHHHH		17.5225627689
308PhosphorylationEEFTRKLYVELKSSP
HHHHHHHHHHECCCC		8.5622461510
313PhosphorylationKLYVELKSSPQPHLV
HHHHHECCCCCCCCH		60.9325159151
314PhosphorylationLYVELKSSPQPHLVP
HHHHECCCCCCCCHH		26.4325159151
368PhosphorylationVTTSPVVTTTVSSSQ
EECCCEEEEEECCCC		19.5827282143
374PhosphorylationVTTTVSSSQSEKSII
EEEEECCCCCCCEEE		30.1627282143
376PhosphorylationTTVSSSQSEKSIIVS
EEECCCCCCCEEEEE		49.2727282143
383O-linked_GlycosylationSEKSIIVSGATAPRT
CCCEEEEECCCCCCE		16.5830059200
395PhosphorylationPRTVSVQTLNPLAGP
CCEEEEEECCCCCCC		26.75-
434PhosphorylationGTGLLQTSKPLVTSV
CCCCCCCCCCCEEEE		21.2224719451
489O-linked_GlycosylationPSVKPVVSSAGTTSD
CCCCCEECCCCCCCC		18.0720068230
489O-linked_GlycosylationPSVKPVVSSAGTTSD
CCCCCEECCCCCCCC		18.0730059200
502PhosphorylationSDKPVIGTPVQIKLA
CCCCCCCCCEEEEEC		14.7925159151
516PhosphorylationAQPGPVLSQPAGIPQ
CCCCCCCCCCCCCCC		34.06-
544PhosphorylationGGNEKQVTTISHSST
CCCCEEEEEEECCCE		18.8729978859
545PhosphorylationGNEKQVTTISHSSTL
CCCEEEEEEECCCEE		22.9429978859
547PhosphorylationEKQVTTISHSSTLTI
CEEEEEEECCCEEEE		18.4129978859
549PhosphorylationQVTTISHSSTLTIQK
EEEEEECCCEEEEEE		20.4429978859
550PhosphorylationVTTISHSSTLTIQKC
EEEEECCCEEEEEEC		23.2429978859
551PhosphorylationTTISHSSTLTIQKCG
EEEECCCEEEEEECC		30.8229978859
553O-linked_GlycosylationISHSSTLTIQKCGQK
EECCCEEEEEECCCE		22.8130059200
553PhosphorylationISHSSTLTIQKCGQK
EECCCEEEEEECCCE		22.8129978859
561O-linked_GlycosylationIQKCGQKTMPVNTII
EEECCCEEECCCEEE		20.8630059200
561PhosphorylationIQKCGQKTMPVNTII
EEECCCEEECCCEEE		20.8620068231
566PhosphorylationQKTMPVNTIIPTSQF
CEEECCCEEEECCCC		22.1020068231
570PhosphorylationPVNTIIPTSQFPPAS
CCCEEEECCCCCCHH		25.4220068231
570O-linked_GlycosylationPVNTIIPTSQFPPAS
CCCEEEECCCCCCHH		25.4230059200
571PhosphorylationVNTIIPTSQFPPASI
CCEEEECCCCCCHHH		25.1920068231
571O-linked_GlycosylationVNTIIPTSQFPPASI
CCEEEECCCCCCHHH		25.1930059200
577PhosphorylationTSQFPPASILKQITL
CCCCCCHHHEEECCC		33.9424719451
595PhosphorylationKILSLQASPTQKNRI
EEEEEECCHHCHHHH		18.6025159151
597PhosphorylationLSLQASPTQKNRIKE
EEEECCHHCHHHHHH		50.0830108239
599UbiquitinationLQASPTQKNRIKENV
EECCHHCHHHHHHHH		51.15-
670UbiquitinationRILDIGKKHDITELN
HHHHHCHHCCCHHCC		41.10-
731UbiquitinationSQLKFLEKLDQLEKQ
HHHHHHHHHHHHHHH		60.56-
799UbiquitinationAAIGPRKKRPLESGI
HHCCCCCCCCCHHCC		61.60-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAF4B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAF4B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAF4B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TF65_HUMANRELAphysical
9724652
TAF1_HUMANTAF1physical
15601843
TAF12_HUMANTAF12physical
15601843
TF2AA_HUMANGTF2A1physical
15601843
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615841Spermatogenic failure 13 (SPGF13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAF4B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-595, AND MASSSPECTROMETRY.

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