GLRA4_HUMAN - dbPTM
GLRA4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLRA4_HUMAN
UniProt AC Q5JXX5
Protein Name Glycine receptor subunit alpha-4
Gene Name GLRA4
Organism Homo sapiens (Human).
Sequence Length 417
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell membrane
Multi-pass membrane protein .
Protein Description Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents..
Protein Sequence MTTLVPATLSFLLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQRLEEDIIQESRFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPLLREGETTRKLYVD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34PhosphorylationLAKEEVKSGTKGSQP
HHHHHHHHCCCCCCC		57.7929759185
39PhosphorylationVKSGTKGSQPMSPSD
HHHCCCCCCCCCHHH		32.4429759185
43PhosphorylationTKGSQPMSPSDFLDK
CCCCCCCCHHHHHHH		28.12-
45PhosphorylationGSQPMSPSDFLDKLM
CCCCCCHHHHHHHHC		33.42-
58PhosphorylationLMGRTSGYDARIRPN
HCCCCCCCCCCCCCC		13.2419664994
162PhosphorylationFKNGNVLYSIRLTLI
CCCCCEEEEEHHHHH		9.5830243723
163PhosphorylationKNGNVLYSIRLTLIL
CCCCEEEEEHHHHHH		9.3224719451
167PhosphorylationVLYSIRLTLILSCLM
EEEEEHHHHHHHHHH		11.25-
243PhosphorylationHYNTGKFTCIEVKFH
ECCCCCEEEEEEEEH		18.9624719451
293PhosphorylationARVGLGITTVLTMTT
HHHCCCEEEEEEEEC		14.7324732914
294PhosphorylationRVGLGITTVLTMTTQ
HHCCCEEEEEEEECC		16.1724732914
297PhosphorylationLGITTVLTMTTQSSG
CCEEEEEEEECCCCC		14.2424732914
299PhosphorylationITTVLTMTTQSSGSR
EEEEEEEECCCCCCC		19.2224732914
300PhosphorylationTTVLTMTTQSSGSRA
EEEEEEECCCCCCCC		18.6824732914
302PhosphorylationVLTMTTQSSGSRASL
EEEEECCCCCCCCCC		34.2824732914
303PhosphorylationLTMTTQSSGSRASLP
EEEECCCCCCCCCCC		30.8524732914
305PhosphorylationMTTQSSGSRASLPKV
EECCCCCCCCCCCCC		26.9924732914
308PhosphorylationQSSGSRASLPKVSYV
CCCCCCCCCCCCCHH		44.0624732914
314PhosphorylationASLPKVSYVKAIDIW
CCCCCCCHHHHHHHH		14.68-
369PhosphorylationEEDIIQESRFYFRGY
HHHHHHHHCHHHCCC		16.0026546556
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLRA4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLRA4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLRA4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GLRA4_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLRA4_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory