| UniProt ID | VGLU2_HUMAN | |
|---|---|---|
| UniProt AC | Q9P2U8 | |
| Protein Name | Vesicular glutamate transporter 2 | |
| Gene Name | SLC17A6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 582 | |
| Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Membrane Multi-pass membrane protein . Cell junction, synapse, synaptosome . |
|
| Protein Description | Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.. | |
| Protein Sequence | MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Phosphorylation | GKSLGQIYRVLEKKQ CCCHHHHHHHHHHCC | 6.18 | - | |
| 100 | N-linked_Glycosylation | VAIVDMVNNSTIHRG EEEEECCCCCCCCCC | 30.05 | UniProtKB CARBOHYD | |
| 101 | N-linked_Glycosylation | AIVDMVNNSTIHRGG EEEECCCCCCCCCCC | 29.17 | UniProtKB CARBOHYD | |
| 109 | Ubiquitination | STIHRGGKVIKEKAK CCCCCCCCCHHHHHC | 43.54 | - | |
| 162 | Phosphorylation | FGAAILLTSTLNMLI HHHHHHHHHHHHHHC | 19.07 | 25278378 | |
| 163 | Phosphorylation | GAAILLTSTLNMLIP HHHHHHHHHHHHHCC | 30.76 | 25278378 | |
| 164 | Phosphorylation | AAILLTSTLNMLIPS HHHHHHHHHHHHCCC | 19.54 | 25278378 | |
| 171 | Phosphorylation | TLNMLIPSAARVHYG HHHHHCCCHHHHHCC | 27.80 | 25278378 | |
| 177 | Phosphorylation | PSAARVHYGCVIFVR CCHHHHHCCHHHHHH | 14.90 | 24927040 | |
| 281 | Phosphorylation | ITDEERRYIEESIGE CCHHHHHHHHHHHHH | 20.93 | 21394647 | |
| 405 | Phosphorylation | TLLLVVGYSHTRGVA EEEEHHCCCCHHHHH | 5.91 | 22210691 | |
| 470 | N-linked_Glycosylation | IVGAMTKNKSREEWQ HEEECCCCCCHHHHH | 38.07 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VGLU2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VGLU2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VGLU2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of VGLU2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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