| UniProt ID | CMTR2_HUMAN | |
|---|---|---|
| UniProt AC | Q8IYT2 | |
| Protein Name | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 | |
| Gene Name | CMTR2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 770 | |
| Subcellular Localization | Nucleus . Cytoplasm . | |
| Protein Description | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.. | |
| Protein Sequence | MSKCRKTPVQQLASPASFSPDILADIFELFAKNFSYGKPLNNEWQLPDPSEIFTCDHTELNAFLDLKNSLNEVKNLLSDKKLDEWHEHTAFTNKAGKIISHVRKSVNAELCTQAWCKFHEILCSFPLIPQEAFQNGKLNSLHLCEAPGAFIASLNHYLKSHRFPCHWSWVANTLNPYHEANDDLMMIMDDRLIANTLHWWYFGPDNTGDIMTLKFLTGLQNFISSMATVHLVTADGSFDCQGNPGEQEALVSSLHYCEVVTALTTLGNGGSFVLKMFTMFEHCSINLMYLLNCCFDQVHVFKPATSKAGNSEVYVVCLHYKGREAIHPLLSKMTLNFGTEMKRKALFPHHVIPDSFLKRHEECCVFFHKYQLETISENIRLFECMGKAEQEKLNNLRDCAIQYFMQKFQLKHLSRNNWLVKKSSIGCSTNTKWFGQRNKYFKTYNERKMLEALSWKDKVAKGYFNSWAEEHGVYHPGQSSILEGTASNLECHLWHILEGKKLPKVKCSPFCNGEILKTLNEAIEKSLGGAFNLDSKFRPKQQYSCSCHVFSEELIFSELCSLTECLQDEQVVVPSNQIKCLLVGFSTLRNIKMHIPLEVRLLESAELTTFSCSLLHDGDPTYQRLFLDCLLHSLRELHTGDVMILPVLSCFTRFMAGLIFVLHSCFRFITFVCPTSSDPLRTCAVLLCVGYQDLPNPVFRYLQSVNELLSTLLNSDSPQQVLQFVPMEVLLKGALLDFLWDLNAAIAKRHLHFIIQREREEIINSLQLQN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | TPVQQLASPASFSPD CCHHHHCCCCCCCHH | 25159151 | ||
| 17 | Phosphorylation | QQLASPASFSPDILA HHHCCCCCCCHHHHH | 25627689 | ||
| 74 | Acetylation | KNSLNEVKNLLSDKK HHHHHHHHHHHCCCC | 25953088 | ||
| 74 | Ubiquitination | KNSLNEVKNLLSDKK HHHHHHHHHHHCCCC | 29967540 | ||
| 74 | Malonylation | KNSLNEVKNLLSDKK HHHHHHHHHHHCCCC | 26320211 | ||
| 81 | Ubiquitination | KNLLSDKKLDEWHEH HHHHCCCCHHHHHHH | 29967540 | ||
| 94 | Ubiquitination | EHTAFTNKAGKIISH HHHHHCCCHHHHHHH | 29967540 | ||
| 97 | Ubiquitination | AFTNKAGKIISHVRK HHCCCHHHHHHHHHH | 29967540 | ||
| 100 | Phosphorylation | NKAGKIISHVRKSVN CCHHHHHHHHHHHCC | - | ||
| 311 | Phosphorylation | ATSKAGNSEVYVVCL CCCCCCCCEEEEEEE | 30631047 | ||
| 332 | Ubiquitination | AIHPLLSKMTLNFGT HHHHHHHHCCCCCCH | 29967540 | ||
| 334 | Phosphorylation | HPLLSKMTLNFGTEM HHHHHHCCCCCCHHH | - | ||
| 342 | Ubiquitination | LNFGTEMKRKALFPH CCCCHHHHHHHHCCC | - | ||
| 342 | Acetylation | LNFGTEMKRKALFPH CCCCHHHHHHHHCCC | 25953088 | ||
| 344 | Ubiquitination | FGTEMKRKALFPHHV CCHHHHHHHHCCCCC | 29967540 | ||
| 355 | Phosphorylation | PHHVIPDSFLKRHEE CCCCCCHHHHHHHHH | 24719451 | ||
| 358 | Ubiquitination | VIPDSFLKRHEECCV CCCHHHHHHHHHHHE | - | ||
| 370 | Phosphorylation | CCVFFHKYQLETISE HHEEEEEHHHHHHHH | 29083192 | ||
| 374 | Phosphorylation | FHKYQLETISENIRL EEEHHHHHHHHHHHH | 29083192 | ||
| 376 | Phosphorylation | KYQLETISENIRLFE EHHHHHHHHHHHHHH | 29083192 | ||
| 387 | Ubiquitination | RLFECMGKAEQEKLN HHHHHCCHHHHHHHH | 22817900 | ||
| 392 | Ubiquitination | MGKAEQEKLNNLRDC CCHHHHHHHHHHHHH | 21906983 | ||
| 422 | Ubiquitination | RNNWLVKKSSIGCST CCCEEEEHHHCCCCC | 29967540 | ||
| 423 | Phosphorylation | NNWLVKKSSIGCSTN CCEEEEHHHCCCCCC | 26657352 | ||
| 424 | Phosphorylation | NWLVKKSSIGCSTNT CEEEEHHHCCCCCCC | 24719451 | ||
| 432 | Ubiquitination | IGCSTNTKWFGQRNK CCCCCCCCCCCCCCC | - | ||
| 439 | Ubiquitination | KWFGQRNKYFKTYNE CCCCCCCCCCCHHCH | 23000965 | ||
| 442 | Ubiquitination | GQRNKYFKTYNERKM CCCCCCCCHHCHHHH | 23000965 | ||
| 442 | Methylation | GQRNKYFKTYNERKM CCCCCCCCHHCHHHH | - | ||
| 448 | Ubiquitination | FKTYNERKMLEALSW CCHHCHHHHHHHHCH | 23000965 | ||
| 456 | Acetylation | MLEALSWKDKVAKGY HHHHHCHHHHHHHHH | 19826891 | ||
| 456 | Ubiquitination | MLEALSWKDKVAKGY HHHHHCHHHHHHHHH | 29967540 | ||
| 506 | Ubiquitination | GKKLPKVKCSPFCNG CCCCCCCCCCCCCCH | - | ||
| 525 | Ubiquitination | TLNEAIEKSLGGAFN HHHHHHHHHHCCCCC | 21906983 | ||
| 536 | Ubiquitination | GAFNLDSKFRPKQQY CCCCCCCCCCCCCCE | 29967540 | ||
| 608 | Phosphorylation | LLESAELTTFSCSLL ECCCCCCEEEEEHHC | 24719451 | ||
| 609 | Phosphorylation | LESAELTTFSCSLLH CCCCCCEEEEEHHCC | 24719451 | ||
| 675 | Phosphorylation | FITFVCPTSSDPLRT HHHHCCCCCCCHHHH | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CMTR2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CMTR2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CMTR2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PARVA_HUMAN | PARVA | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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