DDT4L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDT4L_HUMAN
• UniProt AC: Q96D03
• Protein Name: DNA damage-inducible transcript 4-like protein
• Gene Name: DDIT4L
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Cytoplasm.
• Protein Description: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1..
• Protein Sequence: MVATGSLSSKNPASISELLDCGYHPESLLSDFDYWDYVVPEPNLNEVIFEESTCQNLVKMLENCLSKSKQTKLGCSKVLVPEKLTQRIAQDVLRLSSTEPCGLRGCVMHVNLEIENVCKKLDRIVCDSSVVPTFELTLVFKQENCSWTSFRDFFFSRGRFSSGFRRTLILSSGFRLVKKKLYSLIGTTVIEGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Acetylation	SKVLVPEKLTQRIAQ CCEECCHHHHHHHHH	51.25	156565
98	Phosphorylation	DVLRLSSTEPCGLRG HHHHHCCCCCCCCCC	40.34	30257219
146	Phosphorylation	VFKQENCSWTSFRDF EEECCCCCCEEHHHH	44.99	29083192
148	Phosphorylation	KQENCSWTSFRDFFF ECCCCCCEEHHHHHH	11.16	29083192
149	Phosphorylation	QENCSWTSFRDFFFS CCCCCCEEHHHHHHC	16.42	29083192
156	Phosphorylation	SFRDFFFSRGRFSSG EHHHHHHCCCCCCCC	28.77	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDT4L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDT4L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDT4L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRC15_HUMAN	LRRC15	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.