MYH13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYH13_HUMAN
• UniProt AC: Q9UKX3
• Protein Name: Myosin-13
• Gene Name: MYH13
• Organism: Homo sapiens (Human).
• Sequence Length: 1938
• Subcellular Localization: Cytoplasm, myofibril. Thick filaments of the myofibrils.
• Protein Description: Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles..
• Protein Sequence: MSSDAEMAIFGEAAPYLRKPEKERIEAQNRPFDSKKACFVADNKEMYVKGMIQTRENDKVIVKTLDDRMLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKETQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Phosphorylation	NDKVIVKTLDDRMLT CCEEEEEECCCCEEE	25.24	25954137
71	Phosphorylation	TLDDRMLTLNNDQVF ECCCCEEECCCCCEE	20.35	25954137
95	Phosphorylation	IEDMAMMTHLHEPAV HHHHHHHHCCCCHHH	14.27	26437602
104	Phosphorylation	LHEPAVLYNLKERYA CCCHHHHCCHHHHHH	16.32	26437602
130	"N6,N6,N6-trimethyllysine"	CVTVNPYKWLPVYKP EEEECCCCCCCCCCH	43.44	-
130	Methylation	CVTVNPYKWLPVYKP EEEECCCCCCCCCCH	43.44	-
157	Phosphorylation	EAPPHIFSISDNAYQ CCCCCEEECCCCEEE	22.15	22210691
159	Phosphorylation	PPHIFSISDNAYQFM CCCEEECCCCEEEEE	24.50	25850435
163	Phosphorylation	FSISDNAYQFMLTDR EECCCCEEEEEEECC	14.45	25850435
168	Phosphorylation	NAYQFMLTDRDNQSI CEEEEEEECCCCCEE	19.73	22210691
174	Phosphorylation	LTDRDNQSILITGES EECCCCCEEEEECCC	26.14	22210691
178	Phosphorylation	DNQSILITGESGAGK CCCEEEEECCCCCCC	31.30	22210691
195	Phosphorylation	NTKRVIQYFATIAVT CHHHHHHHEEEEEEC	5.53	-
236	Ubiquitination	LEAFGNAKTVRNDNS HHHHCCCEEECCCCC	52.10	22817900
243	Phosphorylation	KTVRNDNSSRFGKFI EEECCCCCCCCCEEE	26.25	29514088
244	Phosphorylation	TVRNDNSSRFGKFIR EECCCCCCCCCEEEE	37.57	29514088
248	Ubiquitination	DNSSRFGKFIRIHFG CCCCCCCEEEEEEEC	34.60	-
257	Phosphorylation	IRIHFGATGKLASAD EEEEECCCCCCCCCC	34.92	26437602
262	Phosphorylation	GATGKLASADIETYL CCCCCCCCCCHHHHH	36.59	22673903
267	Phosphorylation	LASADIETYLLEKSR CCCCCHHHHHHHCCE	21.58	22673903
268	Phosphorylation	ASADIETYLLEKSRV CCCCHHHHHHHCCEE	9.12	22817900
272	Ubiquitination	IETYLLEKSRVTFQL HHHHHHHCCEEEEEC	43.46	29901268
355	Phosphorylation	KVGIYKLTGAVMHYG CCCEEEHHHHHHHHC	20.95	21712546
361	Phosphorylation	LTGAVMHYGNMKFKQ HHHHHHHHCCCCHHH	7.66	21712546
380	Phosphorylation	EQAEPDGTEVADKAG HHCCCCCCCHHHHHH	34.37	26437602
412	Phosphorylation	RVKVGNEYVTKGQNV CEEECCEEECCCCCH	19.88	19764811
414	Phosphorylation	KVGNEYVTKGQNVQQ EECCEEECCCCCHHH	28.67	26437602
415	Acetylation	VGNEYVTKGQNVQQV ECCEEECCCCCHHHH	48.75	30586227
423	Phosphorylation	GQNVQQVTNSVGALA CCCHHHHHHHHHHHH	19.89	23403867
451	Phosphorylation	RINQQLDTKQPRQYF HHHHHCCCCCCCHHE	39.92	26437602
504	Acetylation	VLEQEEYKKEGIEWE EECHHHHHHCCCCEE	47.86	30586209
548	Phosphorylation	MFPKATDTSFKNKLY CCCCCCCCHHHHHHH	31.54	24769528
549	Phosphorylation	FPKATDTSFKNKLYD CCCCCCCHHHHHHHH	36.71	24769528
555	Phosphorylation	TSFKNKLYDQHLGKS CHHHHHHHHHHCCCC	18.37	26437602
598	Acetylation	NIAGWLDKNKDPLNE HHEHHHCCCCCCCCH	64.82	7664707
606	Phosphorylation	NKDPLNETVVGLYQK CCCCCCHHHHHHHHH	21.30	-
611	Phosphorylation	NETVVGLYQKSSLKL CHHHHHHHHHHHHHH	14.15	26437602
626	Phosphorylation	LSFLFSNYAGAETGD HHHHHHCCCCCCCCC	12.76	-
664	Phosphorylation	ENLNKLMTNLRSTHP HHHHHHHHHHHHHCC	41.35	19764811
668	Phosphorylation	KLMTNLRSTHPHFVR HHHHHHHHHCCCCEE	33.94	26437602
669	Phosphorylation	LMTNLRSTHPHFVRC HHHHHHHHCCCCEEE	32.75	26437602
682	Phosphorylation	RCLIPNETKTPGVMD EEECCCCCCCCCHHH	47.02	26437602
719	Phosphorylation	GFPSRILYADFKQRY CCCCEEEECCHHHHH	11.18	-
799	Phosphorylation	TQAVCRGYLMRVEFK HHHHHHHHHHHHHHH	4.30	24719451
820	Phosphorylation	DSIFCIQYNIRSFMN CCEEEEEEHHHHHCC	7.82	-
883	Phosphorylation	ELEEKMVSLLQEKND HHHHHHHHHHHHHCC	21.62	26437602
897	Phosphorylation	DLQLQVQSETENLMD CHHHHHHHHHHCCCC	47.86	22210691
899	Phosphorylation	QLQVQSETENLMDAE HHHHHHHHHCCCCHH	35.11	22210691
964	Phosphorylation	DIDDLELTLTKVEKE CHHHHHHHHHHHHHH	24.01	28270605
966	Phosphorylation	DDLELTLTKVEKEKH HHHHHHHHHHHHHHH	28.01	28270605
1046	Acetylation	EGSLEQEKKLRADLE CCCHHHHHHHHHHHH	57.72	30586221
1092	Phosphorylation	KKKEFELSQLQAKID HHHHHHHHHHHHHCC	22.96	-
1141	Phosphorylation	AKIEKQRSDLARELE HHHHHHHHHHHHHHH	34.19	-
1186	Phosphorylation	RRDLEEATLQHEATA HHHHHHHHHHHHHHH	30.17	19764811
1192	Phosphorylation	ATLQHEATAATLRKK HHHHHHHHHHHHHHH	17.53	19764811
1195	Phosphorylation	QHEATAATLRKKQAD HHHHHHHHHHHHHHH	25.32	19764811
1203	Phosphorylation	LRKKQADSVAELGEQ HHHHHHHHHHHHHHH	26.66	26437602
1223	Ubiquitination	RVKQKLEKEKSELKM HHHHHHHHHHHHHHH	79.48	-
1286	Phosphorylation	MQKARLQTQNGELSH HHHHHHHHCCCCCCH	28.70	-
1292	Phosphorylation	QTQNGELSHRVEEKE HHCCCCCCHHHHHHH	12.63	28634298
1300	Phosphorylation	HRVEEKESLISQLTK HHHHHHHHHHHHHHH	41.91	20044836
1306	Phosphorylation	ESLISQLTKSKQALT HHHHHHHHHHHHHHH	26.15	20044836
1313	Phosphorylation	TKSKQALTQQLEELK HHHHHHHHHHHHHHH	19.79	23403867
1351	Phosphorylation	CDLLREQYEEEQEAK HHHHHHHHHHHHHHH	22.13	-
1370	Phosphorylation	RALSKANSEVAQWRT HHHHHHHHHHHHHHH	38.00	19764811
1377	Phosphorylation	SEVAQWRTKYETDAI HHHHHHHHHHHHHHH	34.71	26437602
1379	Phosphorylation	VAQWRTKYETDAIQR HHHHHHHHHHHHHHH	24.37	19764811
1381	Phosphorylation	QWRTKYETDAIQRTE HHHHHHHHHHHHHHH	27.86	19764811
1387	Phosphorylation	ETDAIQRTEELEEAK HHHHHHHHHHHHHHH	19.89	20068231
1394	Acetylation	TEELEEAKKKLAQRL HHHHHHHHHHHHHHH	54.44	19867113
1395	Acetylation	EELEEAKKKLAQRLQ HHHHHHHHHHHHHHH	61.13	30586215
1396	Acetylation	ELEEAKKKLAQRLQE HHHHHHHHHHHHHHH	48.63	30586233
1417	Phosphorylation	TANSKCASLEKTKQR HHHHHHHHHHHHHHH	46.67	24719451
1421	Phosphorylation	KCASLEKTKQRLQGE HHHHHHHHHHHHHHH	24.04	24719451
1439	Phosphorylation	LMRDLERSHTACATL HHHHHHHHHCHHHHH	18.80	-
1441	Phosphorylation	RDLERSHTACATLDK HHHHHHHCHHHHHCH	25.36	-
1445	Phosphorylation	RSHTACATLDKKQRN HHHCHHHHHCHHHHC	35.06	-
1480	Phosphorylation	AAQKESRSLSTELFK HHHHHHHHHHHHHHH	35.63	19764811
1482	Phosphorylation	QKESRSLSTELFKMR HHHHHHHHHHHHHHH	22.53	19764811
1483	Phosphorylation	KESRSLSTELFKMRN HHHHHHHHHHHHHHH	41.84	19764811
1514	Phosphorylation	KNLQEEISDLTEQIA CCHHHHHHHHHHHHH	29.82	-
1517	Phosphorylation	QEEISDLTEQIAETG HHHHHHHHHHHHHHC	30.73	-
1594	Phosphorylation	IEQLKRNSQRAAEAL HHHHHHHHHHHHHHH	25.69	24719451
1603	Phosphorylation	RAAEALQSVLDAEIR HHHHHHHHHHHHHHH	26.04	24719451
1611	Phosphorylation	VLDAEIRSRNDALRL HHHHHHHCHHHHHHH	40.89	26437602
1643	Phosphorylation	SNRQMAETQKHLRTV CHHHHHHHHHHHHHH	33.12	27174698
1649	Phosphorylation	ETQKHLRTVQGQLKD HHHHHHHHHHHHHHC	24.44	27174698
1657	Phosphorylation	VQGQLKDSQLHLDDA HHHHHHCCCCCHHHH	32.81	27174698
1706	Phosphorylation	TERTRRLSEQELLDA HHHHHHCCHHHHCCH	35.11	18452278
1725	Phosphorylation	QLLHSQNTSLINTKK HHHHHCCCCCCCCHH	19.78	28509920
1726	Phosphorylation	LLHSQNTSLINTKKK HHHHCCCCCCCCHHH	34.50	28509920
1730	Phosphorylation	QNTSLINTKKKLEAD CCCCCCCCHHHHHHH	36.93	28509920
1764	Phosphorylation	EKAKKAITDAAMMAE HHHHHHHHHHHHHHH	25.17	30576142
1774	Acetylation	AMMAEELKKEQDTSA HHHHHHHHHHHCCHH	58.50	30586239
1775	Ubiquitination	MMAEELKKEQDTSAH HHHHHHHHHHCCHHH	73.55	30230243
1779	Phosphorylation	ELKKEQDTSAHLERM HHHHHHCCHHHHHHH	27.75	26437602
1780	Phosphorylation	LKKEQDTSAHLERMK HHHHHCCHHHHHHHH	23.21	26437602
1793	Phosphorylation	MKKNLEQTVKDLQHR HHHHHHHHHHHHHHH	21.83	26437602
1810	Ubiquitination	EAEQLALKGGKKQIQ HHHHHHHHHCHHHHH	61.07	22817900
1813	Ubiquitination	QLALKGGKKQIQKLE HHHHHHCHHHHHHHH	50.61	22817900
1814	Ubiquitination	LALKGGKKQIQKLEN HHHHHCHHHHHHHHH	56.77	22817900
1818	Ubiquitination	GGKKQIQKLENRVRE HCHHHHHHHHHHHHH	60.44	22817900
1881	Phosphorylation	KLQAKVKSYKRQAEE HHHHHHHHHHHHHHH	38.58	29978859
1882	Phosphorylation	LQAKVKSYKRQAEEA HHHHHHHHHHHHHHH	12.41	29978859
1895	Phosphorylation	EAEEQANTQLSRCRR HHHHHHHHHHHHHHH	33.62	29978859
1898	Phosphorylation	EQANTQLSRCRRVQH HHHHHHHHHHHHHHH	21.37	29978859
1919	Phosphorylation	ERADIAESQVNKLRA HHHHHHHHHHHHHHH	30.33	19764811
1933	Phosphorylation	AKSRDVGSQKMEE-- HHHCCCCCHHCCC--	26.86	-
1935	Acetylation	SRDVGSQKMEE---- HCCCCCHHCCC----	50.40	20167786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYH13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYH13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYH13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LYST_HUMAN	LYST	physical	26496610
GOGA2_HUMAN	GOLGA2	physical	26496610
HSF1_HUMAN	HSF1	physical	26496610
ITB4_HUMAN	ITGB4	physical	26496610
MYH8_HUMAN	MYH8	physical	26496610
RBM4_HUMAN	RBM4	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
MKNK1_HUMAN	MKNK1	physical	26496610
UBC12_HUMAN	UBE2M	physical	26496610
NOLC1_HUMAN	NOLC1	physical	26496610
K0355_HUMAN	KIAA0355	physical	26496610
YAF2_HUMAN	YAF2	physical	26496610
ATP5S_HUMAN	ATP5S	physical	26496610
NIN_HUMAN	NIN	physical	26496610
CC174_HUMAN	CCDC174	physical	26496610
PF21A_HUMAN	PHF21A	physical	26496610
P3H2_HUMAN	P3H2	physical	26496610
BIRC6_HUMAN	BIRC6	physical	26496610
PKHG1_HUMAN	PLEKHG1	physical	26496610
BHE41_HUMAN	BHLHE41	physical	26496610
ZC3H1_HUMAN	ZFC3H1	physical	26496610
CA226_HUMAN	C1orf226	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.