LSM5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSM5_HUMAN
• UniProt AC: Q9Y4Y9
• Protein Name: U6 snRNA-associated Sm-like protein LSm5
• Gene Name: LSM5
• Organism: Homo sapiens (Human).
• Sequence Length: 91
• Subcellular Localization: Nucleus.
• Protein Description: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formation in vitro..
• Protein Sequence: MAANATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAANATTNP ------CCCCCCCCH	14.93	22223895
6	Phosphorylation	--MAANATTNPSQLL --CCCCCCCCHHHCC	27.24	19664995
20	Ubiquitination	LPLELVDKCIGSRIH CCHHHHHHHHCCCEE	21.92	21890473
67	Phosphorylation	TPEGRRITKLDQILL CCCCCCCCCHHEEEE	24.60	27461979
68	Acetylation	PEGRRITKLDQILLN CCCCCCCCHHEEEEC	47.93	23236377
68	Ubiquitination	PEGRRITKLDQILLN CCCCCCCCHHEEEEC	47.93	-
80	Phosphorylation	LLNGNNITMLVPGGE EECCCCEEEEEECCC	13.43	27461979

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LSM5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSM5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSM5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUXE_HUMAN	SNRPE	physical	15231747
LSM6_HUMAN	LSM6	physical	22939629
LSM7_HUMAN	LSM7	physical	22939629
RMI2_HUMAN	RMI2	physical	22939629
SPTB1_HUMAN	SPTB	physical	22939629
PP1RA_HUMAN	PPP1R10	physical	22939629
UBE3A_HUMAN	UBE3A	physical	22939629
MI4GD_HUMAN	MIF4GD	physical	22939629
TF2B_HUMAN	GTF2B	physical	22939629
RUXF_HUMAN	SNRPF	physical	22365833
LSM6_HUMAN	LSM6	physical	22365833
LSM7_HUMAN	LSM7	physical	22365833
LSM7_HUMAN	LSM7	physical	15231747
RUXF_HUMAN	SNRPF	physical	15231747
LSM3_HUMAN	LSM3	physical	15231747
LSM6_HUMAN	LSM6	physical	15231747
LSM7_HUMAN	LSM7	physical	25416956
LSM2_HUMAN	LSM2	physical	26344197
LSM3_HUMAN	LSM3	physical	26344197
LSM4_HUMAN	LSM4	physical	26344197
LSM6_HUMAN	LSM6	physical	26344197
LSM7_HUMAN	LSM7	physical	26344197
LSMD1_HUMAN	NAA38	physical	26344197
PATL1_HUMAN	PATL1	physical	28514442
POLH_HUMAN	POLH	physical	28514442
ZN511_HUMAN	ZNF511	physical	28514442
AKA7A_HUMAN	AKAP7	physical	28514442
AKA7G_HUMAN	AKAP7	physical	28514442
LSM1_HUMAN	LSM1	physical	28514442
STPAP_HUMAN	TUT1	physical	28514442
ZGPAT_HUMAN	ZGPAT	physical	28514442
PRPF3_HUMAN	PRPF3	physical	28514442
LSM4_HUMAN	LSM4	physical	28514442
SNR27_HUMAN	SNRNP27	physical	28514442
LSM7_HUMAN	LSM7	physical	28514442
LSM2_HUMAN	LSM2	physical	28514442
MEPCE_HUMAN	MEPCE	physical	28514442
HPLN3_HUMAN	HAPLN3	physical	28514442
LSM8_HUMAN	LSM8	physical	28514442
LSM3_HUMAN	LSM3	physical	28514442
TMCO6_HUMAN	TMCO6	physical	28514442
SART3_HUMAN	SART3	physical	28514442
S100B_HUMAN	S100B	physical	28514442
PRP4_HUMAN	PRPF4	physical	28514442
RBM42_HUMAN	RBM42	physical	28514442
RDH13_HUMAN	RDH13	physical	28514442
PRP31_HUMAN	PRPF31	physical	28514442
SNUT1_HUMAN	SART1	physical	28514442
SMD2_HUMAN	SNRPD2	physical	28514442
RUXF_HUMAN	SNRPF	physical	28514442
NH2L1_HUMAN	NHP2L1	physical	28514442
DDX23_HUMAN	DDX23	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330