| UniProt ID | LSM1_HUMAN | |
|---|---|---|
| UniProt AC | O15116 | |
| Protein Name | U6 snRNA-associated Sm-like protein LSm1 | |
| Gene Name | LSM1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 133 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, P-body . | |
| Protein Description | Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. [PubMed: 18172165 Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity] | |
| Protein Sequence | MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLDEY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MNYMPGTASL -----CCCCCCCHHH | 11.91 | 23663014 | |
| 7 | Phosphorylation | -MNYMPGTASLIEDI -CCCCCCCHHHHHHH | 13.75 | 23663014 | |
| 9 | Phosphorylation | NYMPGTASLIEDIDK CCCCCCHHHHHHHCC | 29.71 | 23663014 | |
| 123 | Phosphorylation | ALKDRGLSIPRADTL HHHHCCCCCCCCCCC | 33.11 | 25159151 | |
| 129 | Phosphorylation | LSIPRADTLDEY--- CCCCCCCCCCCC--- | 34.81 | 25159151 | |
| 133 | Phosphorylation | RADTLDEY------- CCCCCCCC------- | 24.42 | 23090842 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LSM1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LSM1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LSM1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SYNC_HUMAN | NARS | physical | 15231747 | |
| PSB5_HUMAN | PSMB5 | physical | 15231747 | |
| GRHPR_HUMAN | GRHPR | physical | 15231747 | |
| VPS11_HUMAN | VPS11 | physical | 15231747 | |
| EXOS8_HUMAN | EXOSC8 | physical | 15231747 | |
| EXOS6_HUMAN | EXOSC6 | physical | 15231747 | |
| N4BP1_HUMAN | N4BP1 | physical | 15231747 | |
| LSM2_HUMAN | LSM2 | physical | 15231747 | |
| SMD3_HUMAN | SNRPD3 | physical | 22939629 | |
| SMD2_HUMAN | SNRPD2 | physical | 22939629 | |
| PRPF3_HUMAN | PRPF3 | physical | 22939629 | |
| PRP4_HUMAN | PRPF4 | physical | 22939629 | |
| PATL1_HUMAN | PATL1 | physical | 22939629 | |
| SHIP2_HUMAN | INPPL1 | physical | 22939629 | |
| WASL_HUMAN | WASL | physical | 22939629 | |
| NSD2_HUMAN | WHSC1 | physical | 22939629 | |
| PSB8_HUMAN | PSMB8 | physical | 15231747 | |
| LSM3_HUMAN | LSM3 | physical | 15231747 | |
| TM214_HUMAN | TMEM214 | physical | 15231747 | |
| UXT_HUMAN | UXT | physical | 15231747 | |
| HS90A_HUMAN | HSP90AA1 | physical | 15231747 | |
| RRP1B_HUMAN | RRP1B | physical | 15231747 | |
| MPU1_HUMAN | MPDU1 | physical | 15231747 | |
| DHE3_HUMAN | GLUD1 | physical | 15231747 | |
| LSM4_HUMAN | LSM4 | physical | 15231747 | |
| LSM3_HUMAN | LSM3 | physical | 25416956 | |
| PRPF3_HUMAN | PRPF3 | physical | 26344197 | |
| RUXE_HUMAN | SNRPE | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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