TMCO6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMCO6_HUMAN
• UniProt AC: Q96DC7
• Protein Name: Transmembrane and coiled-coil domain-containing protein 6
• Gene Name: TMCO6
• Organism: Homo sapiens (Human).
• Sequence Length: 493
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MWSRRQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPETQQTFIRLEGSMRTLVGLLTSNQALLQLEAARCLHELSHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQRLWPGPLLPALLHTLAFSDTEVVGQSLELLHLLFLYQPEAVQVFLQQSGLQALERHQEEAQLQDRVYALQQTALQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	RREQQLVSKRLLRND HHHHHHHHHHHHHCC	22.20	-
42	Ubiquitination	REQQLVSKRLLRNDA HHHHHHHHHHHHCCC	39.32	-
42	Acetylation	REQQLVSKRLLRNDA HHHHHHHHHHHHCCC	39.32	25953088
89	Phosphorylation	EREGALVSLRRGLQH HHHHHHHHHHHCCCC	19.60	24719451
316	Phosphorylation	CPVLRCLSNLLTEAA HHHHHHHHHHHHHHH	29.11	23879269
320	Phosphorylation	RCLSNLLTEAAVETV HHHHHHHHHHHHHHH	27.09	23879269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMCO6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMCO6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMCO6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBB_HUMAN	UBB	physical	26186194
CCPG1_HUMAN	CCPG1	physical	26186194
DPP9_HUMAN	DPP9	physical	26186194
PHIPL_HUMAN	PHYHIPL	physical	26186194
MINP1_HUMAN	MINPP1	physical	26186194
PHIPL_HUMAN	PHYHIPL	physical	28514442
DPP9_HUMAN	DPP9	physical	28514442
UBB_HUMAN	UBB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.