ABTB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABTB2_HUMAN
• UniProt AC: Q8N961
• Protein Name: Ankyrin repeat and BTB/POZ domain-containing protein 2
• Gene Name: ABTB2
• Organism: Homo sapiens (Human).
• Sequence Length: 1025
• Protein Description: May be involved in the initiation of hepatocyte growth..
• Protein Sequence: MAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYSGSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQNTLAERVHSVYITSRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAGTYSSTLKTLEDL CCCCCHHHCCCHHHC	51.33	68707535
11	Phosphorylation	TYSSTLKTLEDLTLD CCHHHCCCHHHCCCC	38.85	28985074
29	Phosphorylation	GAGDSCRSLSLSSSK CCCHHCCHHCCCCCC	5.58	28102081
31	Phosphorylation	GDSCRSLSLSSSKSN CHHCCHHCCCCCCCH	20.63	28985074
33	Phosphorylation	SCRSLSLSSSKSNSQ HCCHHCCCCCCCHHH	4.91	25159151
34	Phosphorylation	CRSLSLSSSKSNSQA CCHHCCCCCCCHHHH	11.31	28102081
35	Phosphorylation	RSLSLSSSKSNSQAL CHHCCCCCCCHHHHH	6.57	28102081
36	Ubiquitination	SLSLSSSKSNSQALN HHCCCCCCCHHHHHH	20.11	29967540
37	Phosphorylation	LSLSSSKSNSQALNS HCCCCCCCHHHHHHH	2.44	28450419
39	Phosphorylation	LSSSKSNSQALNSSA CCCCCCHHHHHHHHH	34.20	28450419
58	Phosphorylation	GAAWWCYSGSMNSRH CCCEEECCCCCCCCC	17.68	27251275
60	Phosphorylation	AWWCYSGSMNSRHNS CEEECCCCCCCCCCC	3.52	27251275
63	Phosphorylation	CYSGSMNSRHNSWDT ECCCCCCCCCCCCCC	13.35	27251275
67	Phosphorylation	SMNSRHNSWDTVNTV CCCCCCCCCCCCHHC	71.97	23663014
70	Phosphorylation	SRHNSWDTVNTVLPE CCCCCCCCCHHCCCC	26.95	23663014
73	Phosphorylation	NSWDTVNTVLPEDPE CCCCCCHHCCCCCHH	28.67	23663014
152	Ubiquitination	RLSVLHAKCTRFEVQ HHHHHHHHCCHHHHH	22.78	29901268
183	Phosphorylation	LAAVKALSLYSMSAG HHHHHHHHHHCCCCC	42.90	45744047
188	Phosphorylation	ALSLYSMSAGDGLRR HHHHHCCCCCCCHHC	44.21	28787133
299	Ubiquitination	NANGVLSLPAYFSPY CCCCCEECCEEECCC	45.31	21906983
320	Phosphorylation	HDERADAYAQLELRT CCHHHHHHHHHHHHH	9.33	27642862
365	Phosphorylation	HPLCPGASPARQARQ CCCCCCCCHHHHCCC	40.51	29255136
398	Phosphorylation	LRCPQMESMENPNLD HHCCCHHCCCCCCCC	2.37	50655453
485	Ubiquitination	DARAATEKFNQDLGF HHHHHHHHHHHHHCC	48.95	22817900
677	Ubiquitination	LTQPQQAKADVLSLE HCCHHHHHCCCCCHH	3.44	29967540
691	Ubiquitination	EEILAEGVEESDASS HHHHHHCCCCCCCCC	46.32	21906983
694	Phosphorylation	LAEGVEESDASSQGS HHHCCCCCCCCCCCC	68.05	28348404
697	Phosphorylation	GVEESDASSQGSGSE CCCCCCCCCCCCCCC	59.01	28348404
698	Phosphorylation	VEESDASSQGSGSEG CCCCCCCCCCCCCCC	38.98	28348404
701	Phosphorylation	SDASSQGSGSEGPVR CCCCCCCCCCCCCCC	26.28	27251275
754	Phosphorylation	IWIESLRTSFSQSRY EHHHHHHHHCHHHHH	32.63	29083192
755	Phosphorylation	WIESLRTSFSQSRYS HHHHHHHHCHHHHHH	5.98	29083192
757	Phosphorylation	ESLRTSFSQSRYSVV HHHHHHCHHHHHHHH	3.30	29083192
766	Phosphorylation	SRYSVVQSLLRDFSS HHHHHHHHHHHCHHH	5.81	24719451
812	Ubiquitination	QQLATIFTHCYGSSP HHHHHHHHHHHCCCC	39.56	21906983
845	Phosphorylation	FLNNKEMSDVTFLVE HCCCCCCCCCEEEEE		27135362
848	Phosphorylation	NKEMSDVTFLVEGKL CCCCCCCEEEEECEE		27135362
877	Ubiquitination	FKTLMTNKSEQDGDS HHHHHCCCCCCCCCC		22817900
996	Phosphorylation	RQLIYGRSSKVQGLD HHHHHCCCCCCCCCC		21955146
997	Phosphorylation	QLIYGRSSKVQGLDP HHHHCCCCCCCCCCH		21955146
998	Ubiquitination	LIYGRSSKVQGLDPL HHHCCCCCCCCCCHH		22817900
1022	Phosphorylation	RVHSVYITSRV---- HHHHHEEEECC----		30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABTB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABTB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABTB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1A1_HUMAN	EEF1A1	physical	18459963
CUL3_HUMAN	CUL3	physical	18429817
RBX1_HUMAN	RBX1	physical	18429817
TDT_HUMAN	DNTT	physical	18429817

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.